2007
DOI: 10.1016/j.chemphyslip.2007.06.055
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Abstract: the membrane lipid composition, it must be connected to the remainder of the protein via a flexible molecular hinge that allows transmembrane domain VII to reside in the membrane in the normal mode and exit to the periplasmic side of the membrane in the inverted mode. Therefore, the net charge of the cytoplasmic extra-membrane surface and the charge character of the membrane lipid headgroups determine topology. Final topology is established after the N-terminal bundle exits the translocon and is therefore pri…

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