Effect of functional crosslinking agents on preparation and swelling properties of dextran hydrogels

Can, Hatıce Kaplan; Denizli, Betül Kırcı; Güner, Ali̇; Rzaev, Zakır M. O.

doi:10.1016/j.carbpol.2004.08.025

Cited by 25 publications

(11 citation statements)

References 24 publications

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“…Dextran is a polysaccharide produced mainly by bacteria, consisting essentially of ␣-1,6 linked d-glucopyranese residues [13]. This natural polymer has been reported as highly relevant in the biomedical field [14] and has been applied as plasma expander [15] and in the development of drug delivery systems [16], hydrogels [17] and wound dressings [18] among others.…”

Section: Introductionmentioning

confidence: 99%

Photocrosslinkable biodegradable responsive hydrogels as drug delivery systems

Almeida

Ferreira

Lopes

et al. 2011

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

Photocrosslinkable biodegradable responsive hydrogels as drug delivery systems

Almeida

Ferreira

Lopes

et al. 2011

International Journal of Biological Macromolecules

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“…This could be also seen from their swelling behavior. Analysis of swelling and diffusion kinetic parameters 6,7,[24][25][26][27][28][29][30] To assess the influence of the surfactant-hydrogel interactions on the swelling/diffusion characteristics, we utilized NISA 1 hydrogel swelling data in different ionic (5 mM) and nonionic (1.5 wt %) surfactant solutions. Figure 7 clearly presents the pattern of various swelling/diffusion kinetic parameters such as diffusion constant (n), diffusion coefficient (D), and penetration velocity (v) of NISA 1 in various swelling media, which were calculated according to eqs.…”

Section: Resultsmentioning

confidence: 99%

“…The equilibrium swelling ratio (S eq ) and equilibrium water content (EWC%) were calculated using eqs. (1) and (2), respectively: [26][27][28][29][30] where M e and M d are the weights of water present in the swollen hydrogel at equilibrium and weight of dry hydrogel, respectively.…”

Section: Swelling Studiesmentioning

confidence: 99%

Poly(N‐isopropylacrylamide‐co‐sodium acrylate) hydrogels: Interactions with surfactants

Mohan

Joseph

Geckeler

2006

J of Applied Polymer Sci

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Poly(N-isopropylacrylamide-co-sodium acrylate) [poly(NIPAM-co-SA)] hydrogels were modified with three different kind of surfactants (cationic, anionic, and nonionic) to study the effect on the swelling properties. The structural variation of the surfactant-modified hydrogels was investigated in detail. The interaction between the surfactants and the hydrogel varies and strictly depends on the surfactant type. The variation in thermal stability of the modified surfactant hydrogels was investigated and compared with unmodified hydrogel. Further, the hydrogel swelling/diffusion kinetic parameters were investigated and diffusion of water into hydrogel was found to be of the non-Fickian transport mechanism.

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“…Several physical cross-linking methods such as ionic interactions, coiled-coil interactions, and stereo-complex formation can be utilized (Hennink et al 2004). On the other hand, chemical cross-links can be done by reacting the hydrophilic functional groups of the polymer with one of the several cross-linking agents, e.g., diisocyanates (Hoygaard et al 1995), epichlorohydrin, phosphorus oxychloride (POCl 3 ) (Denizli et al 2004;Can et al 2005), glutaraldehyde (Brondsted et al 1998), etc. Jiang et al (2004 reported a successful preparation of dextran fibrous membranes by e-spinning.…”

Section: Introductionmentioning

confidence: 99%

Electrospun dextran fibrous membranes

et al. 2008

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Ultra-fine fiber mats of dextran (powder; M w = 64,000-76,000 Da) were fabricated by electrospinning, using water as the solvent. The effects of solution concentration (i.e., 0.7-1.3 g mL -1 ) and applied electric field (9-21 kV/15 cm) on morphological appearance and size of the obtained fibers were investigated. Under a fixed electric field of 15 kV/15 cm and a fixed solution flow rate of 0.25 mL h -1 , beaded fibers were observed up to a critical concentration of about 0.9 g mL -1 , beyond which only smooth fibers were obtained. The average diameter of these fibers increased monotonically with increasing the solution concentration (i.e., from *290 to *1950 nm). For the dextran solutions investigated, increasing the electric field generally caused the diameters of the obtained fibers to increase, with the average diameter of the obtained fibers ranging between 520 and 1760 nm. To improve the usefulness of the electrospun dextran fiber mats in an aqueous medium, cross-linking with glutaraldehyde was necessary. The effects of curing temperature (i.e., 70-90°C), curing time (i.e., 3-48 h), and added MgCl 2 catalyst (i.e., 0.01-0.03 g) on physical integrity of the cross-linked dextran membranes in water were investigated. Both the swelling and the weight loss in water of the crosslinked membranes were generally found to decrease with increasing curing temperature, curing time, and MgCl 2 loading and the cross-linking did not affect the morphology of the obtained membranes.

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Effect of functional crosslinking agents on preparation and swelling properties of dextran hydrogels

Cited by 25 publications

References 24 publications

Photocrosslinkable biodegradable responsive hydrogels as drug delivery systems

Photocrosslinkable biodegradable responsive hydrogels as drug delivery systems

Poly(N‐isopropylacrylamide‐co‐sodium acrylate) hydrogels: Interactions with surfactants

Electrospun dextran fibrous membranes

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