Effect of fumonisin B1 on protein and lipid synthesis in primary rat hepatocytes

Gelderblom, Wentzel C. A.; Smuts, Cornelius M.; Abel, Stefan; Snyman, S.D.; Cawood, M.E.; Westhuizen, L. van der; Swanevelder, Sonja

doi:10.1016/0278-6915(96)00107-x

Cited by 60 publications

(27 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…fumonisin B1 ( fig. 4) is an important fumonisins mycotoxin which was reported to be a hepatotoxic and carcinogenic toxin (28,116,117). In addition, fumonisin B1 was reported to cause apoptosis in the liver of rats (118) and there is a possibility that it can be linked to esophageal cancer (119).…”

Section: The Action Of Mycotoxins On the Cellular Genome And Its Effementioning

confidence: 99%

Effects of different mycotoxins on humans, cell genome and their involvement in cancer

et al. 2017

View full text Add to dashboard Cite

Abstract. The chemical nature of most of the mycotoxins makes them highly liposoluble compounds that can be absorbed from the site of exposure such as from the gastrointestinal and respiratory tract to the blood stream where it can be dissimilated throughout the body and reach different organs such as the liver and kidneys. Mycotoxins have a strong tendency and ability to penetrate the human and animal cells and reach the cellular genome where it causes a major mutagenic change in the nucleotide sequence which leads to strong and permanent defects in the genome. This defect will eventually be transcribed, translated and lead to the development of cancer. In this review, the chemical and physical nature of mycotoxins, the action of mycotoxins on the cellular genome and its effect on humans, mycotoxins and their carcinogenicity and mycotoxins research gaps are discussed, and new research areas are suggested. The research review posed various questions. What are the different mycotoxins that can cause cancer, what is the role of mycotoxins in causing cancer and what types of cancers can be caused by mycotoxins? These questions have been selected due to the significant increase in the mycotoxin contamination and the cancer incidence rate in the contemporary world. By revealing and understanding the role of mycotoxins in developing cancer, measures to reduce the risks and incidents of cancer could be taken.

show abstract

Section: The Action Of Mycotoxins On the Cellular Genome And Its Effementioning

confidence: 99%

Effects of different mycotoxins on humans, cell genome and their involvement in cancer

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This suggests that disturbed SL metabolism is behind FB 1 toxicity (21,29,49). However, the mechanism by which changes in SL biosynthesis induce cell death is not clear.…”

Section: Figure 2 Structural Formula Of Sphingolipids and Sphingoid Bmentioning

confidence: 99%

Fumonisin B1: A Neurotoxic Mycotoxin / Fumonizin B1: Neurotoksični Mikotoksin

Domijan

2012

Archives of Industrial Hygiene and Toxicology

View full text Add to dashboard Cite

Fumonisin B 1 (FB 1 ) is a mycotoxin produced by Fusarium spp. moulds that contaminate crop, predominantly maize, all around the world. More than 15 types of fumonisins have been indentifi ed so far, but FB 1 is the most abundant and toxicologically the most signifi cant one. FB 1 has a wide range of toxic effects, depending on animal species. In horses FB 1 causes equine leukoencephalomalacia (ELEM), in pigs pulmonary oedema and in experimental rodents nephrotoxicity and hepatotoxicity. In humans exposure to FB 1 is linked with higher incidence of primary liver cancer and oesophageal cancer, which are frequent in certain regions of the world (such as Transkei region in South Africa) where maize is staple food. The occurrence of neural tube defect in children in some countries of Central America (such as Mexico and Honduras) is connected with the consumption of FB 1 -contaminated maize-based food. However, possible involvement of FB 1 in the development of human diseases is not clear. Nevertheless, the International Agency for Research on Cancer (IARC) has classifi ed FB 1 as a possible carcinogen to humans (group 2B). FB 1 is a causative agent of ELEM, a brain disorder in equines, indicating that brain is a target organ of FB 1 toxicity. Several studies on experimental animals or on cell cultures of neural origin have established that FB 1 has a neurodegenerative potential, although the mechanism of its neurotoxicity is still vague. The aim of this article is to give an overview of available literature on FB 1 neurotoxicity and involved mechanisms, and to offer a new perspective for future studies.

show abstract

“…For example, several groups have presented data suggesting that fumonisins cause compositional or oxidative damage to cellular lipids, which in turn causes molecular events culminating in oxidative damage to DNA and other critical macromolecules (94)(95)(96)(97)(98)(99). A more detailed discussion of molecular mechanism is beyond the purpose of this review but can be found elsewhere in this issue (87,(100)(101)(102).…”

Section: Fumonisins and Sphingolipids: Mechanistic Considerationsmentioning

confidence: 99%

An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme.

Voss

Riley

Norred

et al. 2001

Environ Health Perspect

121

View full text Add to dashboard Cite

Fumonisins are produced by Fusarium moniliforme F. verticillioides) and other Fusarium that grow on corn worldwide. They cause fatal toxicoses of horses and swine. Their effects in humans are unclear, but epidemiologic evidence suggests that consumption of fumonisin-contaminated corn contributes to human esophageal cancer in southern Africa and China. Much has been learned from rodent studies about fumonisin B1(FB1), the most common homologue. FB1 is poorly absorbed and rapidly eliminated in feces. Minor amounts are retained in liver and kidneys. Unlike other mycotoxins, fumonisins cause the same liver cancer promotion and subchronic (studies (3/4) 90 days) liver and kidney effects as (italic)F. moniliforme. FB 1 induces apoptosis of hepatocytes and of proximal tubule epithelial cells. More advanced lesions in both organs are characterized by simultaneous cell loss (apoptosis and necrosis) and proliferation (mitosis). Microscopic and other findings suggest that an imbalance between cell loss and replacement develops, a condition favorable for carcinogenesis. On the molecular level, fumonisins inhibit ceramide synthase, and disrupt sphingolipid metabolism and, theoretically, sphingolipid-mediated regulatory processes that influence apoptosis and mitosis. Liver sphingolipid effects and toxicity are correlated, and ceramide synthase inhibition occurs in liver and kidney at doses below their respective no-observed-effect levels. FB1 does not cross the placenta and is not teratogenic in vivoin rats, mice, or rabbits, but is embryotoxic at high, maternally toxic doses. These data have contributed to preliminary risk evaluation and to protocol development for carcinogenicity and chronic toxicity studies of FB1 in rats and mice.

show abstract

Effect of fumonisin B1 on protein and lipid synthesis in primary rat hepatocytes

Cited by 60 publications

References 27 publications

Effects of different mycotoxins on humans, cell genome and their involvement in cancer

Effects of different mycotoxins on humans, cell genome and their involvement in cancer

Fumonisin B1: A Neurotoxic Mycotoxin / Fumonizin B1: Neurotoksični Mikotoksin

An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme.

Contact Info

Product

Resources

About