Effect of Folic Acid on Collateral Circulation in Diffuse Chronic Arteriosclerosis

Kopjas, Tibor L.

doi:10.1111/j.1532-5415.1966.tb02875.x

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Folic acid seems to play a dual role in the healing of leg ulcers. It is an effective vasodilator of the micro blood vessels (7) and it contributes to the systemic factor in protein metabolism probably through the co‐enzymatic action which is essential for wound repair.…”

Section: Discussionmentioning

confidence: 99%

Folic Acid for the Treatment of Chronic Leg Ulcers in Elderly Patients

Kopjas

1968

J American Geriatrics Society

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During a three‐month study period, folic‐acid therapy was prescribed for 10 selected office patients (3 males and 7 females) with chronic leg ulcers. The average age was 61. Six of the 10 patients had venous stasis ulcers of various sizes. Four patients had ischemic ulcers. Folic acid was administered orally (as tablets) to all the patients in a dosage of 15 mg three times daily for twelve weeks. Four patients (2 with large varicose ulcers and 2 with ischemic ulcers) received an additional 20‐mg dose of folic acid twice weekly, intravenously. In the first weeks of therapy most of the patients showed marked improvement. In 9 of the 10 cases, complete healing was achieved in six to twelve weeks. In the tenth case there was definite improvement but not complete healing of a toe ulcer. Folic acid plays a dual role in the healing of leg ulcers. It is an effective vasodilator for the microcirculation, and a contributor to adequate protein metabolism.

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Section: Discussionmentioning

confidence: 99%

Folic Acid for the Treatment of Chronic Leg Ulcers in Elderly Patients

Kopjas

1968

J American Geriatrics Society

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“…SINCE FOLIC ACID SEEMED to be an effective vasodilator for small arteries, especially in cases of diffuse chronic arteriosclerosis where the tissue viability must depend on the collateral circulation, 8,9,10 we decided to study its effects in patients with vascular headaches of the migraine type.…”

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The Use of Folic Acid in Vascular Headache of the Migraine Type

Kopjas¹

1969

Headache

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Effect of Folic Acid on Collateral Circulation in Diffuse Chronic Arteriosclerosis

Cited by 2 publications

References 16 publications

Folic Acid for the Treatment of Chronic Leg Ulcers in Elderly Patients

Folic Acid for the Treatment of Chronic Leg Ulcers in Elderly Patients

The Use of Folic Acid in Vascular Headache of the Migraine Type

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