volume 31, issue 1, P22-27 2016
DOI: 10.1590/s0102-865020160010000004
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Abstract: ABSTRACT PURPOSE:To determine the effect of a single dose of adriamycin (ADR) to induce anorectal malformations (ARMs) and determine the effect of folic acid (FA) in this model. METHODS:Ten female Wistar rats were divided randomly in two groups. Group A -ADR; Group B -FA+ADR. Dams from group B received daily, since two weeks before the pregnancy to the end of pregnancy, FA (50mg/kg) by gavage. Dams from both groups received ADR (6mk/kg) by intraperitoneal injection on gestational day (GD) 8. Their fetuses wer…

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