Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation

Fekete, Katalin; Berti, Cristiana; Trovato, Monica; Lohner, Szimonetta; Dullemeijer, Carla; Souverein, Olga W.; Cetin, Irene; Décsi, Támas

doi:10.1186/1475-2891-11-75

Cited by 134 publications

(104 citation statements)

References 40 publications

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“…Moreover, maternal serum folic acid level showed insignificant differences between group A and B (9.57 ± 3.63 vs. 9.1 ± 2.73 respectively, P = 0.27), which contradicts other previous studies as [12] [36] [43]. A systematic review done by Fekete et al [44] showed two-fold increase in folate intake in early pregnancy is associated with 2% increase in birth weight, which is a slight but significant increase. Therefore, Open Journal of Obstetrics and Gynecology vitamin B12 and/or folic acid deficiency is likely to affect methylation pathway of homocysteine to methionine which represents a crucial part of the one-carbon metabolism for synthesis of DNA, and RNA.…”

Section: Discussioncontrasting

confidence: 52%

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Youssry¹,

Radwan²,

Gebreel³

et al. 2017

OJOG

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Objective: The aim of this study is to evaluate vitamin B12, folate, and homocysteine status in pregnant women in the third trimester of pregnancy and their relationship to fetal birth weight and their correlation to corresponding neonatal cord blood levels, and in addition, to evaluate the possibility of maternal serum homocysteine level as a predictor of low birth weight infants. Subjects and Methods: In this cross-sectional study, a total of two hundred pregnant women in third trimester (≥28 weeks) were recruited. After a detailed obstetrical and medical history, and clinical assessment, participants were subdivided into two groups: Group (A)-pregnant women who delivered average birth weight (ABW) infants and Group (B) for those who delivered low birth weight (LBW) infants between completed 37 and 42 weeks. Results: Vitamin B12 deficiency was observed in 24.1% of the total cohort. The mean vitamin B12 level was significantly lower in group (B) compared to group (A) (195.2 ± 38.9 vs. 225.9 ± 66.59 respectively P = 0.008). The mean level of homocysteine for women in group (B) was significantly higher than those determined from women in group (A) (9.10 ± 5.9 vs. 7.6 ± 3.83 respectively, P = 0.042). On the other hand, the mean folate levels showed statistically insignificant differences between both groups. The mean cord vitamin B12 level was significantly lower in LBW infants in comparison to ABW infants (277 ± 61.93 vs. 312.03 ± 81.87 respectively, P = 0.015), while the mean level of cord homocysteine for LBW infants was significantly higher than those levels determined from ABW infants (7.9 ± 3.79 vs. 6.6 ± 2.09 respec- deficiency could be significant risk for LBW infants. Hyperhomocysteinemia has been shown to be a predictor for adverse pregnancy outcomes particularly LBW.

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Section: Discussioncontrasting

confidence: 52%

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Youssry¹,

Radwan²,

Gebreel³

et al. 2017

OJOG

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“…However, no association of plasma folate, folate from food or folic acid from supplements was found with birth size (15). This result differed from the result of a systematic review and meta-analysis including eight randomized controlled studies, which indicated a 2% increase in infant birth weight for every two-fold increase in folate intake (94). No association between intake of total folate and preterm delivery was found in MoBa (33), which is in line with the mentioned systematic review and meta-analysis (94).…”

Section: Possible Explanations For Findings and Comparison With Othercontrasting

confidence: 73%

Diet matters, particularly in pregnancy – Results from MoBa studies of maternal diet and pregnancy outcomes

Brantsæter¹,

Haugen²,

Myhre³

et al. 2014

Nor J Epidemiol

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Awareness that maternal diet may influence the outcome of pregnancy as well as the long-term health of mother and child has increased in recent years. A new food frequency questionnaire (FFQ) was developed and validated specifically for the Norwegian Mother and Child Cohort Study (MoBa). The MoBa FFQ is a semi-quantitative tool which covers the average intake of food, beverages and dietary supplements during the first 4 to 5 months of pregnancy. It includes questions about intakes of 255 foods and dishes and was used from 2002 onwards. Data assessed by the MoBa FFQ is available for 87,700 pregnancies. Numerous sub-studies have examined associations between dietary factors and health outcomes in MoBa. The aim of this paper is to summarize the results from 19 studies of maternal diet and pregnancy outcomes, which is the complete collection of studies based on the MoBa FFQ and published before September 2014. The overall research question is whether maternal diet -from single substances to dietary patterns -matters for pregnancy outcome. The pregnancy outcomes studied till now include birth size measures, infants being small and large for gestational age, pregnancy duration, preterm delivery, preeclampsia, as well as maternal gestational weight gain and postpartum weight retention. As a whole, the results from these studies corroborate that the current dietary recommendations to pregnant women are sound and that maternal diet during pregnancy is likely to contribute to reduce the risk of pregnancy complications including preterm birth, preeclampsia, and reduced foetal growth. The results provide supporting evidence for recommending pregnant women to consume vegetables, fruit, whole grain, fish, dairy, and water regularly and lower the intake of sugar sweetened beverages, processed meat products and salty snacks. The results showing negative impact of even low levels of environmental contaminants support the precautionary advice on consumption of foods containing these. New findings are that particularly lean fish explained the positive association between seafood intake and foetal growth, and the indications of a protective effect of probiotic and antimicrobial foods on pregnancy outcomes. This points to the importance of diet composition for a healthy gut flora and the body's immune response. Although these studies are observational and cannot infer causality, the results identify diet as an important modifiable lifestyle factor, suggesting that healthy eating, defined as following the official recommendations, is particularly important in pregnancy.This is an open access article distributed under the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Thus, by the end of pregnancy, a woman may be at risk for folate deficiency. 34 Low maternal folic acid intake in pregnancy has been associated with increased risk of ASD. 35,36 High maternal BMI related to conception shortly after a previous birth has also been hypothesized to explain the link between short IPI and ASD risk.…”

Section: Discussionmentioning

confidence: 99%

Interpregnancy Interval and Risk of Autism Spectrum Disorders

et al. 2015

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OBJECTIVE: To determine whether subsequent births after short and long interpregnancy intervals (IPIs) are associated with risk of autism spectrum disorder (ASD). METHOD:We assessed the association between IPI and ASD risk in a cohort of 45 261 children born at Kaiser Permanente Northern California (KPNC) between 2000 and 2009. Children with ASD were identified from International Classification of Diseases, Revision 9 diagnostic codes 299.0, 299.8, and 299.9 recorded in KPNC electronic medical records. IPI was defined as the time from the birth of the first child to the conception of the second child. Survival analysis and logistic regression models were used to evaluate the association between IPI and risk of ASD in second-born children.

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Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation

Cited by 134 publications

References 40 publications

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

The Impact of Third Trimester Maternal Serum Vitamin B12 and Folate Status on Fetal Birth Weight. Is Maternal Serum Homocysteine a Predictor of Low Birth Weight Infants?

Diet matters, particularly in pregnancy – Results from MoBa studies of maternal diet and pregnancy outcomes

Interpregnancy Interval and Risk of Autism Spectrum Disorders

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