Effect of fluconazole consumption on long-term trends in candidal ecology

Abstract

Despite long-term exposure to fluconazole, no change in candidal ecology was observed.

Incidence, characteristics and outcome of ICU-acquired candidemia in India

“…In another study Fournier et al reported a significantly higher proportion of C. parapsilosis due to prior exposure to caspofungin [25]. In contrast, Blot et al reported no change in Candida species [26]. Therefore, more studies are required to understand the interplay of the factors responsible for any shift in Candida species distribution.…”

Morbidity and Mortality of Bloodstream Infections in Patients With Severe Burn Injury

“…[24][25][26] Antimicrobial resistance was defined 24,27,28 as resistance to fluconazole for Candida species, as resistance to methicillin for staphylococci, as resistance to vancomycin for enterococci, as resistance to ampicillin for streptococci, as production of extended-spectrum β-lactamases for Enterobacter species, and as resistance to 1 of the following agents for gram-negative nonfermenting bacteria: ceftazidime, piperacillin, ciprofloxacin, imipenem, or meropenem.…”

Multilocus Microsatellite Markers for Molecular Typing of Candida glabrata : Application to Analysis of Genetic Relationships between Bloodstream and Digestive System Isolates

“…Candida glabrata is the most significant species that has emerged and now regularly ranks number two, after C. albicans, as the etiologic agent of superficial and invasive candidiasis occurring in adults (17,27). Reasons for this change in species distribution remain uncertain but may be partially due to the natural resistance of C. glabrata to azole derivates, widely used since the 1980s (6,10,26). This lower susceptibility of C. glabrata to azoles (2,23,38) and delayed initiation of therapy due to delayed diagnosis (2,20,35) may explain in part why the prognosis for C. glabrata candidemia is worse than that for C. albicans candidemia (7,18,41,51).…”