Effect of Flavonol Derivatives on the Carrageenin-Induced Paw Edema in the Rat and Inhibition of Cyclooxygenase-1 and 5-Lipoxygenase in Vitro

Sobottka, Andréa Michel; Werner, Wolfgang; Blaschke, Gottfried; Kiefer, Werner; Nowe, Ulrike; Dannhardt, Gerd; Schapoval, Elfrides Eva Scherman; Schenkel, Eloir P.; Scriba, Gerhard K. E.

doi:10.1002/1521-4184(20007)333:7<205::aid-ardp205>3.3.co;2-p

Cited by 3 publications

(4 citation statements)

References 6 publications

(7 reference statements)

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“…Although our results may appear to conflict with previous studies that demonstrated the anti-inflammatory properties of quercetin in different acute models of inflammation (Sobottka et al 2000;Morikawa et al 2003), the present study showed that quercetin, given orally, failed to reduce the fever induced by either intravenous or intraperitoneal injection of LPS. We hypothesized that intraperitoneal injection of quercetin would inhibit LPS-induced fever because this route of administration would protect quercetin from being metabolized by intestinal microorganisms or enzymes from epithelial cells (Blaut et al 2003;Rasmussen & Breinholt 2003).…”

Section: Discussioncontrasting

confidence: 99%

“…Quercetin has been widely studied in herbal medicine as a possible candidate molecule to treat inflammatory chronic diseases such as rheumatoid arthritis and colitis (Comalada et al 2005;Mamani-Matsuda et al 2006), and it also shows anti-inflammatory properties in several animal models of acute inflammation (Sobottka et al 2000;Morikawa et al 2003). However, to our knowledge, there is no evidence of the antipyretic effect of quercetin.…”

Section: Discussionmentioning

confidence: 99%

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Quercetin does not alter lipopolysaccharide-induced fever in rats

Kanashiro

Machado

Malvar

et al. 2008

Journal of Pharmacy and Pharmacology

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Fever is considered an important component of the acute phase response of the body in defence against invading organisms such as bacteria. Quercetin, an important representative of the flavonoid class, has been extensively studied as an anti-inflammatory agent. In the present study, we investigated the effect of quercetin, administered orally (5, 25 and 50 mg kg(-1)) or intraperitoneally (50 mg kg(-1)), on the febrile response induced by either intraperitoneally (50 mug kg(-1)) or intravenously (5 mug kg(-1)) injected lipopolysaccharide (LPS from Escherichia coli) in rats. In contrast with the well known anti-inflammatory activity of quercetin, the results demonstrate that quercetin, at the doses used, did not alter the fever induced by LPS, regardless of the route of administration.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quercetin does not alter lipopolysaccharide-induced fever in rats

Kanashiro

Machado

Malvar

et al. 2008

Journal of Pharmacy and Pharmacology

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“…In view of ethoxyl radicals in B ring (14)(15)(16)(17)(18), the promising antiviral activity was linked to the presence of two of this radical in meta position (18). Compounds with butoxyl radicals in B ring (22)(23)(24)(25)(26) also showed activity, with higher activity for orto/meta positions of this radical (25).…”

Section: Discussionmentioning

confidence: 99%

“…Flavonols identified as 8, 10, 12, 20, 21, 28, 29, 31, 32 and 34 were purchased from Sigma and others were synthesized [26]. Flavones identified as 49, 54, 55 and 57 were synthesized [26] and others were purchased from Sigma.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of antirotavirus activity of flavonoids

et al. 2010

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Flavonoids are dietary components and the most ubiquitous phenolic compounds found in nature, showing a range of pharmacological activities including antiviral action. This study describes the antiviral screening of 60 different flavones and flavonols against human rotavirus (Wa-1 strain) as well as their cytotoxicity in MA104 cells. Cytotoxicity was investigated by cell morphology assessment and antirotavirus activity by cytopathic effect inhibition. Results were expressed as CC(50) and IC(50), respectively, in order to calculate the selectivity index (SI = CC(50)/IC(50)) of each compound. Structure-activity relationships (SAR) were proposed based on antirotavirus activity.

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Quercetin Promotes Functional Recovery Following Acute Spinal Cord Injury

Schültke

Kendall

Kamencic

et al. 2003

Journal of Neurotrauma

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We tested the hypothesis that quercetin, a potent Fe(2+)-chelating flavonoid, would decrease secondary damage following spinal cord trauma. MRI studies using the relaxation of the T1 proton signal caused by Fe(2+) ions and the dose-dependent reversal of this effect by addition of quercetin in aqueous solution were used to guide us to the dosage of quercetin to be used in animal experimentations. Forty-four male Wistar rats were used in two experimental series to test the hypothesis that administration of quercetin improves recovery of motor function after acute traumatic spinal cord injury. Animals were subjected to laminectomy and subjected to an extradural 40-g force clip compression for 5 sec at T7. Quercetin or saline was administered intraperitoneally 1 h after injury and then every 12 hr thereafter. Recovery of motor function was assessed using BBB scores at weekly intervals for 4 weeks. A dose of 2.5 micromoles quercetin/kg body weight did not result in significantly better functional outcome, whereas doses ranging from 5 to 100 micromoles quercetin/kg body weight resulted in a significantly better functional outcome with half or more of the animals walking, although with deficit; in contrast, no animals walked in the group of saline-treated animals. No significant differences in behavioral outcome were seen amongst the doses ranging from 5 to 100 micromol/kg, nor was there a difference if animals were treated for 4 or 10 days. Therapeutic outcome was coincident with more efficient iron clearance, suggesting that one possible mechanism whereby quercetin decreases secondary damage is through iron chelation.

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Effect of Flavonol Derivatives on the Carrageenin-Induced Paw Edema in the Rat and Inhibition of Cyclooxygenase-1 and 5-Lipoxygenase in Vitro

Abstract: Arch. Pharm. Pharm. Med. Chem.

Cited by 3 publications

References 6 publications

Quercetin does not alter lipopolysaccharide-induced fever in rats

Quercetin does not alter lipopolysaccharide-induced fever in rats

Evaluation of antirotavirus activity of flavonoids

Quercetin Promotes Functional Recovery Following Acute Spinal Cord Injury

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