Effect of female age on the diagnostic categories of infertility

Maheshwari, Abha; Hamilton, Mark; Bhattacharya, Siladitya

doi:10.1093/humrep/dem431

Cited by 190 publications

(127 citation statements)

References 21 publications

(22 reference statements)

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“…Compared to women, the decline in male reproductive capacity with age is less pronounced and men are considered to be able to have a child throughout their lifespan. In literature, the role and the importance of maternal age in fertilization has been extensively studied; however, the effect of the paternal age is poorly understood [1][2][3][4][5]. Now, especially in developed countries, the fact that couples postpone having a child due to economic reasons, high standards of living, or career planning has substantially increased the significance of research for investigating the effects of aging on reproductive systems [1].…”

Section: Introductionmentioning

confidence: 99%

Effects of aging on the male reproductive system

Güneş

Hekim

Arslan

et al. 2016

J Assist Reprod Genet

190

118

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The study aims to discuss the effects of aging on the male reproductive system. A systematic review was performed using PubMed from 1980 to 2014. Aging is a natural process comprising of irreversible changes due to a myriad of endogenous and environmental factors at the level of all organs and systems. In modern life, as more couples choose to postpone having a child due to various socioeconomic reasons, research for understanding the effects of aging on the reproductive system has gained an increased importance. Paternal aging also causes genetic and epigenetic changes in spermatozoa, which impair male reproductive functions through their adverse effects on sperm quality and count as, well as, on sexual organs and the hypothalamic-pituitarygonadal axis. Hormone production, spermatogenesis, and testes undergo changes as a man ages. These small changes lead to decrease in both the quality and quantity of spermatozoa. The offspring of older fathers show high prevalence of genetic abnormalities, childhood cancers, and several neuropsychiatric disorders. In addition, the latest advances in assisted reproductive techniques give older men a chance to have a child even with poor semen parameters. Further studies should investigate the onset of gonadal senesce and its effects on aging men.

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Section: Introductionmentioning

confidence: 99%

Effects of aging on the male reproductive system

Güneş

Hekim

Arslan

et al. 2016

J Assist Reprod Genet

190

118

View full text Add to dashboard Cite

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“…This trend is presenting new challenges to fertility specialists who are witnessing a corresponding rise in the mean age at which women first present with infertility [4,5]. It is known that the outcome of assisted reproductive technology (ART) is adversely affected by advancing maternal age and the need to optimise treatment for these women has never been more pertinent [6].…”

Section: Introductionmentioning

confidence: 99%

What is the best treatment option for infertile women aged 40 and over?

Armstrong

Akande

2013

J Assist Reprod Genet

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Purpose To summarise the causes of decreased fecundity with age and review chronological vs biological ovarian ageing. To explore the clinician's means of assessing a woman's ovarian reserve. To review the recent literature on the effectiveness of different assisted reproductive technology (ART) techniques for women aged 40 and over and offer a single best treatment option. Methods Pubmed and google scholar were searched for relevant articles using key words. Data were extracted based on authors, year, aims, sample and results. Results Success rates for women aged 40 or over with clomiphene, IUI, IUI with FSH are all extremely low, at less than 1 % live birth per cycle. However, IVF offers a success rate of around 13.7 % per cycle. Conclusion An exploration of the effectiveness of available treatment options for older infertile women using their own gametes suggests that IVF offers the best prospects of success. Attempting treatments other than IVF will delay conception unnecessarily.

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“…Ovulatory dysfunction accounts for 21% to 32%, tubal factor 14% to 26%, unexplained 8% to 30% and endometriosis accounts 4% to 6% of female infertility. [2][3][4] Hysterolaparoscopy gives detailed and magnified view of uterine, adenexal, peritoneal and other intra-abdominal pathology. Consequently, milder degree of distal fimbrial pathology, endometriosis, and pelvic adhesions can be diagnosed and treated at the same time which was missed during a routine trans vaginal ultrasonography.…”

Section: Introductionmentioning

confidence: 99%

Role of hysterolaparoscopy for the evaluation of primary infertility: An experience from a tertiary care hospital

Pande

Dora

Pradhan

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONInfertility is one of the most common problem for which couple seeks medical attention. It is seen almost in 10-15% of the reproductive couple.1 Though there are various tests available for the evaluation of the patients with infertility, for the complete evaluation of pelvic pathology hysterolaparoscopy became the gold standard over the years. Ovulatory dysfunction accounts for 21% to 32%, tubal factor 14% to 26%, unexplained 8% to 30% and endometriosis accounts 4% to 6% of female infertility.2-4 Hysterolaparoscopy gives detailed and magnified view of uterine, adenexal, peritoneal and other intra-abdominal pathology. Consequently, milder degree of distal fimbrial pathology, endometriosis, and pelvic adhesions can be diagnosed and treated at the same time which was missed during a routine trans vaginal ultrasonography. The main objective of the study was to assess the role of diagnostic hysterolaparoscopy in the diagnosis and treatment of primary infertility patients. METHODSThis was a hospital based retrospective observational study. Medical records of all cases of primary infertility were retrieved and analyzed. This study was conducted ABSTRACT Background: Infertility is one of the most common problem for which couple seeks medical attention. The main objective of the study was to assess the role of diagnostic hysterolaparoscopy in the diagnosis and treatment of primary infertility patients. Methods: For this retrospective study, patient with the diagnosis of primary infertility were recruited. Patients admitted between the periods 2014 to 2016 were included. Pertinent data related to infertility were collected from the case records and entered in predesigned performa. Results: Patients with primary infertility 246 (82%) diagnosed to have pelvic pathology. The most common cause of infertility was ovarian 122 (36.63%), Uterine 66 (19.82%), tubal 84 (25.22%) and unexplained infertility in 103 (30.93%) women. Patients with PCOS 76 (22.82%) and endometriosis 46 (13.81%) treated with drilling and endometriotic cystectomy. In 32 (9.60%) of patients hysteroscopic cannulation was done. For distal tubal blockage fimbrioplasty was performed in 38 (11.41%) of women. Pelvic adhesions diagnosed in 26 (7.80%) women. patients diagnosed with uterine septum 42 (12.61%) required hysteroscopic septal resection. During the evaluation of infertility 70 (21%) of women diagnosed to have incidental pelvic pathology treated according to pathology. Conclusions: Hysterolaparoscopy is emerging as a valuable technique for complete assessment of female infertility and also helps in treatment according to the cause.

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Effect of female age on the diagnostic categories of infertility

Abstract: The causes of infertility in older women are different from those in younger women. Women over 35 years of age are nearly twice as likely to present with unexplained infertility.

Cited by 190 publications

References 21 publications

Effects of aging on the male reproductive system

Effects of aging on the male reproductive system

What is the best treatment option for infertile women aged 40 and over?

Role of hysterolaparoscopy for the evaluation of primary infertility: An experience from a tertiary care hospital

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