Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats

Matysek, M.; Mozel, Sylwia; Szalak, Radosław; Zacharko-Siembida, Anna; Obszańska, K; Arciszewski, Marcin B.

doi:10.1515/pjvs-2017-0038

Cited by 8 publications

(7 citation statements)

References 32 publications

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“…At present, there is little information in the literature on the impact of bilberries on the CNS in the course of diabetes. The previous, pioneer study by the authors of the current study showed that antioxidants present in bilberry fruit affect morphology, and probably show beneficial effects on hippocampal neurons during diabetes [39]. It was also shown that long-term supplementation with bilberry extract prevents learning deficits, as discussed by Subash et al [47].…”

Section: Discussionsupporting

confidence: 63%

“…Although the peripheral effects of bilberry in living organisms are ambiguous, its role in the treatment of DM is still important and needs to be explored. In addition, DM also resulted in the disruption of glucose homeostasis in the CNS [39]. Several reports have shown that cognitive functions are disturbed in the course of diabetes, which is associated with structural and electrophysiological alterations and brain atrophy [14,40].…”

Section: Discussionmentioning

confidence: 99%

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Insulin receptors in the CA1 field of hippocampus and selected blood parameters in diabetic rats fed with bilberry fruit

Matysek¹,

Borowiec²,

Szwajgier³

et al. 2021

Ann Agric Environ Med.

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Introduction. Bilberry fruit is believed to be a promising factor in the treatment of diabetes mellitus. Chronic hyperglycaemia affects the function of the central nervous system, which may be manifested as changes in hypothalamic insulin signalling. Materials and method. Using DPPH and ABTS assays, total phenolic content in bilberry fruit and its antioxidant activities were examined. The selected biochemical parameters of blood (glucose, fructosamine, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides), as well as the expression of insulin receptors, were studied in the hippocampal CA1 field of healthy and diabetic (streptozotocin-induced; 60 mg kg-1 body weight) Wistar rats fed with bilberry fruit (16 g kg-1 body weight per day; 6 weeks), as well as of the corresponding control groups. Results. Biochemical analyses revealed ambiguous results, but a significantly (P<0.05) decrease in the level of LDL-cholesterol was observed in the group of healthy rats supplemented with bilberry pulp after 6 weeks of the treatment. There was also a difference (P<0.05) in the level of LDL-cholesterol in the mentioned healthy animals fed with bilberry, versus the healthy control group. An increased number of insulin receptors-immunoreactive neurons as well as nerve fibres in the CA1 field of diabetic rats fed with bilberry fruit was also found. Conclusions. An inclusion of bilberry fruit in the daily diet during the course of diabetes can lead to plasticity of hippocampal neurons/nerve fibres, manifested by changes in insulin receptors expression. Whether or not the observed changes had protective effects (by reducing damages caused by diabetes mellitus) on the function of the central nervous system neurons needs further study.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Insulin receptors in the CA1 field of hippocampus and selected blood parameters in diabetic rats fed with bilberry fruit

Matysek¹,

Borowiec²,

Szwajgier³

et al. 2021

Ann Agric Environ Med.

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“…More specifically, they are used in diabetes-related research to try to prevent and repair some of the brain damage caused by diabetes, particularly tissue loss and reduction in cognitive function and memory [ 90 ]. It was found that bilberries were able to modulate neurodegeneration in diabetic rats by increasing neurotransmitter release and reducing the quantity of ROS in the brain [ 90 ]. The researchers also note that the extract was able to promote healthy morphological modulations in αCaMKII in hippocampal neurons.…”

Section: Neurodegenerative Mechanisms Associated With Ros and Effementioning

confidence: 99%

Biochemical Properties and Neuroprotective Effects of Compounds in Various Species of Berries

2017

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Several species of berries, such as blueberries (Vaccinium angustifolium) and lingonberries (Vaccinium vitis-idaea L.), have attracted much scientific attention in recent years, especially due to their reported antioxidant and anti-inflammatory properties. Berries, as with other types of plants, have developed metabolic mechanisms to survive various environmental stresses, some of which involve reactive oxygen species. In addition, the fruits and leaves of berries have high amounts of polyphenols, such as flavonoids, which act as potent antioxidants. These compounds could potentially be beneficial for brain aging and neurodegenerative disorders. There are now several studies documenting the beneficial effects of various berries in cell models of neurotoxicity as well as in vivo models of neurodegenerative disease. In the current review, we discuss the metabolic strategies that plants and animals have developed in order to combat reactive oxygen species. We then discuss issues of bioavailability of various compounds in mammals and provide a synopsis of studies demonstrating the neuroprotective ability of berries and polyphenols. We also summarize findings from our own research group. For example, we have detected various polyphenols in samples of blueberries and lingonberries and have found that the leaves have a much higher antioxidant capacity than the fruits. Extracts from these species have also demonstrated neuroprotective effects in cellular models of toxicity and inflammation, which are being further pursued in animal models.

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“…Matysek et al (2017) during an investigation on diabetic rats demonstrated that treatment with V. myrtillus fruits causes increase in αCaMKII‐positive nerve fibers length in the hippocampus tissue compared to control group. Calcium/calmodulin‐dependent protein kinase II (CaMKII) is a kinase that found in hippocampus and it is a key factor in learning, memory and behavior.…”

Section: Resultsmentioning

confidence: 99%

Medicinal plants for diabetes associated neurodegenerative diseases: A systematic review of preclinical studies

Khazaei

Pesce

Patruno

et al. 2020

Phytotherapy Research

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Diabetes mellitus is a metabolic defect with many complications for the patients. Deaths due to diabetes and its complications are increasing, and one of the most serious consequences are the neurological disorders. Chemical treatments have irreversible side effect and therefore the aim of this study is to evaluate the medicinal plants used for treatment of cognitive impairments and neurodegenerative diseases associated with diabetes in 2004–2020 period. Electronic databases used were PubMed, Scopus and Cochrane library. The keywords used were “diabetes,” “plant,” “herb,” “neurodegenerative,” “neurodegeneration,” “cognitive,” “cognition,” “Alzheimer,” “dementia.” The non‐English articles, repetitive articles and review studies were excluded. From total of 3,590 results, 58 articles are included in the study. The results show that many chemical treatments considered for this disease simply control hyperglycemia, but cannot improve the complications of diabetes. Herbal medicine could be more effective due to the high antioxidant activity of some medicinal plants. Biologically active substances of medicinal plants can improve the neurological disorders caused by diabetes via several pathways. The most important pathway is related to antioxidant properties. Other pathways include antiinflammatory, anti‐apoptotic, neurotoxicity inhibition, neuronal death, increasing the uptake of glucose by cells and improve neurotransmitters levels involved in learning and memory.

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Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats

Cited by 8 publications

References 32 publications

Insulin receptors in the CA1 field of hippocampus and selected blood parameters in diabetic rats fed with bilberry fruit

Insulin receptors in the CA1 field of hippocampus and selected blood parameters in diabetic rats fed with bilberry fruit

Biochemical Properties and Neuroprotective Effects of Compounds in Various Species of Berries

Medicinal plants for diabetes associated neurodegenerative diseases: A systematic review of preclinical studies

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