Effect of Extremely Low Frequency Electromagnetic Field and GABAA Receptors on Serum Testosterone Level of Male Rats

Taherianfard, Mahnaz; Bahaddini, Aminolah; Keshtkar, Sara; Fazeli, Mehdi; Shomali, Tahoora

doi:10.5812/ijem.11029

Cited by 7 publications

(13 citation statements)

References 23 publications

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“…In 1979, Wertheimer and Leeper first reported that there might be a possible relationship between the electromagnetic fields and childhood cancer (Wertheimer and Leeper, 1979). Recent studies have evaluated the effects of the ELF-EMF on cancer (Chen et al, 2013;Repacholi, 2012), reproductive system (Al-Akhras et al, 2006;Huuskonen et al, 2001;Vallejo and Hidalgo, 2012), endocrine system (Crasson et al, 2001;Karasek and Woldanska-Okonska, 2004;Taherianfard et al, 2013) as well as neurodegenerative diseases (Garcia et al, 2008;Reale et al, 2014;Sobel et al, 1995). However, due to different exposure conditions, such as the duration and the intensity of exposure, there remains considerable controversy surrounding the safety of ELF-EMF.…”

Section: Introductionmentioning

confidence: 99%

Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Lai

Zhang²,

Liu³

et al. 2016

NeuroToxicology

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Recently, extremely low frequency electromagnetic fields (ELF-EMF) have received considerable attentions for their potential pathogenicity. In the present study, we explored the effects of ELF-EMF on behaviors of adult male rats. Sixty adult male rats were randomly divided into two groups, the sham exposure group and the 50Hz/100μT ELF-EMF exposure group. During the 24 weeks exposure, body weight, as well as food and water intake were recorded. Results showed that food and water intake and the body weight of the rats were not affected by the exposure. After 24 weeks exposure, open field test and elevated plus maze were conducted to evaluate the anxiety-like behavior, the tail suspension test and forced swim test were conducted to evaluate depression-like behavior and Morris water maze and fear conditioning tests were used to evaluate the cognitive and memory ability. Exposure to ELF-EMF did not induce any anxiety-like or depression-like behaviors compared with the sham exposure. Moreover, the cognitive and memory ability was not impaired by the ELF-EMF exposure. Furthermore, ELF-EMF exposure did not affect the morphology and histology of the brain. In conclusion, 24 weeks exposure to 50Hz/100μT ELF-EMF had no effect on the behaviors of the adult male rats.

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Section: Introductionmentioning

confidence: 99%

Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Lai

Zhang²,

Liu³

et al. 2016

NeuroToxicology

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“…Related animal study has also shown that exposure to ELF induced males mice spermatagonial cells apoptosis [35]. In hormone level studies, exposure of animals to 50 Hz, 0.5 mT ELF-EMF for 30 days had no appreciable effect on testosterone level as compared to sham exposed animals [36]. However, we observed that serum testosterone level of exposed rats to 50 Hz, 25 lT ELF-EMF for 18 weeks was associated with a significant decrease after 6 and 12 weeks of exposure [37].…”

Section: Discussionmentioning

confidence: 99%

Effects of extremely low-frequency electromagnetic fields (ELF-EMF) exposure on B6C3F1 mice

Zuo

Zhou

et al. 2015

Environ Health Prev Med

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Objective Long-term exposure study was conducted to investigate the effects of extremely low-frequency electromagnetic field on the tumor promotion process and fertility. Methods Ten pregnant C57BL/6NCrj mice were exposed to 50 Hz field 500 mG for 1 week (12 h per day), and 24 male and 42 female B6C3F1mice born from them were further exposed up to 15.5 months. As a control group, 10 pregnant mice were bred without exposure, and 30 produced male and 32 female mice were observed without exposure for the same period. Results Mean body weights of exposed groups of male and female mice were decreased significantly than those of the control groups. In exposed mice, there was no increased incidence of liver and lung tumor. In female mice, the incidence of chronic myeloid leukemia [3/42 (7 %)] in the exposed group was significantly greater than in the control group. The size of seminiferous tubules in the EMF exposed groups were significantly less than the control group. Conclusions These data support the hypothesis that longterm exposure of 50 Hz magnetic fields is a significant risk factor for neoplastic development and fertility in mice.

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“…In several animal studies, as in the present study, no significant relationship was observed between exposure to the magnetic field and reproductive hormones. 11,28,29 In the study of Al-Akhras et al (2006), mice exposed to 25 T for 18 weeks had significantly reduced levels of testosterone after 6 and 12 weeks of exposure, but changes in testosterone levels after 18 weeks were not significant. LH levels increased after 18 weeks of exposure.…”

Section: T a B L E 2 Summary Of Demographicmentioning

confidence: 99%

“…Thus, it seems that the effect of these waves on testosterone levels was not due to central inhibition of pituitary hormone secretion, but rather to the peripheral environment. 29,30,33 There have been numerous human and animal studies on the effect of the exposure to magnetic fields on fertility, with contradictory results. 21,22,24,31,55 In the study by Hjollund et al, no significant relationship was found between ELF exposure of men and women and human reproductive markers.…”

Section: T a B L E 2 Summary Of Demographicmentioning

confidence: 99%

“…20 The results of human and animal studies have differed on the effects of EMF radiation on reproductive hormones. 21 While a number of human and animal studies have reported no change in male reproductive hormones at exposure to EMF, 11,[22][23][24][25][26][27][28][29][30] others have claimed that exposure to EMF can decrease testosterone levels. 18,20,[31][32][33][34][35] Even in some cases, increases in testosterone, LH, and FSH have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between exposure to Extremely Low-Frequency (ELF) magnetic field and the level of some reproductive hormones among power plant workers

Suri

Dehghan

Sahlabadi

et al. 2020

Journal of Occupational Health

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Background and Aims: Today, human beings are exposed to the ELF magnetic field of electrical equipment and power lines, which can damage Leydig cells and alter the secretion of reproductive hormones. The purpose of this study was to investigate the relationship between exposure to ELF magnetic field and the level of some reproductive hormones in male power plant workers. Materials and Methods: The present cross-sectional study was carried out among all male employees of different units of the selected power plant around Tehran, Iran. All participants were asked to complete demographic data sheets and General Health questionnaire, on condition of consent and meeting the inclusion criteria. Timeweighted average (TWA) exposure to magnetic field of 122 men was measured by IEEE Std C95.3.1 method using TES 1393 Gauss meter. Based on the exposure level, subjects were divided into three groups. Serum Levels of Free Testosterone, Luteinizing Hormone (LH), and Follicle stimulating hormone (FSH) in participants were determined. Data analysis was performed using ANOVA, Kruskal-Wallis tests, and the relationships between variables were assessed by linear regression and correlation using SPSS v.25 software. Results: There was no significant statistical correlation between the level of ELF exposure and serum levels of free testosterone, LH, and FSH, (r = 0.158). Serum levels of LH decreased significantly with age and duration of work experience (P < .05, r = −.25, P = .005, r = −.203, P = .025). Conclusion: There was no relationship between exposure to magnetic field in power plants and reproductive hormone levels, although it is impossible to make definitive comments without using more accurate methods to estimate male fertility. K E Y W O R D S extremely low-frequency magnetic field, men's reproductive hormones, occupational exposure, power plant 2 of 10 | SURI et al.

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Effect of Extremely Low Frequency Electromagnetic Field and GABAA Receptors on Serum Testosterone Level of Male Rats

Cited by 7 publications

References 23 publications

Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Effects of extremely low frequency electromagnetic fields (100 μT) on behaviors in rats

Effects of extremely low-frequency electromagnetic fields (ELF-EMF) exposure on B6C3F1 mice

Relationship between exposure to Extremely Low-Frequency (ELF) magnetic field and the level of some reproductive hormones among power plant workers

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