Effect of Exercise on Biomarkers, Fatigue, Sleep Disturbances, and Depressive Symptoms in Older Women With Breast Cancer Receiving Hormonal Therapy

Payne, Jason; Held, Joanne; Thorpe, Josh; Shaw, Heather S.

doi:10.1188/08.onf.635-642

Cited by 181 publications

(141 citation statements)

References 16 publications

(25 reference statements)

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“…No previous study has examined the effects of exercise on sleep quality in patients with lymphoma. In other cancer patient groups, results have been mixed with 3 studies showing benefit (10,14,17) and 4 studies showing no benefit (12,13,15,16).…”

Section: Discussionmentioning

confidence: 94%

“…Seven randomized controlled trials (RCT) have examined the effects of exercise on sleep quality in patients with cancer (10,(12)(13)(14)(15); however, these trials have largely been pilot studies limited by small sample sizes under 75 (10,12,(14)(15)(16)(17), heterogeneous samples with mixed cancer diagnoses (9,12,15), unsupervised exercise interventions (10, 12-14, 16, 17), and short exercise interventions of <12 weeks (10,16,17). Three of these trials have shown significant improvements in sleep quality (10,14,17) whereas 4 have not (12,13,15,16).…”

Section: Introductionmentioning

confidence: 99%

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A Randomized Trial of Aerobic Exercise and Sleep Quality in Lymphoma Patients Receiving Chemotherapy or No Treatments

Courneya

Sellar

Trinh

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Patients with lymphoma experience sleep problems that may be managed with aerobic exercise but no previous study has examined this issue.Methods: We randomized 122 patients with lymphoma to usual care (n ¼ 62) or 12 weeks of supervised aerobic exercise training (AET; n ¼ 60). Our primary sleep endpoint was global sleep quality assessed by the Pittsburgh Sleep Quality Index (PSQI). Secondary endpoints were the PSQI component scores. Planned subgroup analyses were also conducted.Results: Intention-to-treat analyses indicated that AET resulted in a nonsignificant (P ¼ 0.16) improvement in global sleep quality compared with usual care [mean group difference ¼ À0.64; 95% confidence interval (CI), À1.56 to þ0.27]. In planned subgroup analyses, statistically significant or borderline significant interactions were identified for type of lymphoma (P interaction ¼ 0.006), current treatment status (P interaction ¼ 0.036), time since diagnosis (P interaction ¼ 0.010), body mass index (P interaction ¼ 0.075), and baseline sleep quality (P interaction ¼ 0.041). Specifically, AET improved global sleep quality in patients with lymphoma who had indolent non-Hodgkin lymphoma (P ¼ 0.001), were receiving chemotherapy (P ¼ 0.013), were <2 years post-diagnosis (P ¼ 0.005), were obese (P ¼ 0.025), and were poor sleepers at baseline (P ¼ 0.007).Conclusions: AET did not significantly improve sleep quality in this heterogeneous sample of patients with lymphoma; however, clinically identifiable subgroups appeared to benefit. Future exercise trials targeting these responsive subgroups are needed to confirm these findings.Impact: If replicated in larger and more focused trials, aerobic exercise may be an attractive option to manage sleep dysfunction in patients with cancer because of its favorable safety profile and other documented health benefits. Cancer Epidemiol Biomarkers Prev; 21(6); 887-94. Ó2012 AACR.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

A Randomized Trial of Aerobic Exercise and Sleep Quality in Lymphoma Patients Receiving Chemotherapy or No Treatments

Courneya

Sellar

Trinh

et al. 2012

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Twenty-five studies examined exercise interventions exclusively in breast cancer survivors (44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68), 4 in prostate cancer survivors (69-72), 4 in lymphoma (73-76), 1 in leukemia (78), and 1 in colorectal cancer (77). The remaining 9 studies examined exercise interventions in a mixed group of cancer survivors (35)(36)(37)(38)(39)(40)(41)(42)(43) Table 5 characteristics of included studies, Supplementary).…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Exercise Interventions in Modulating Cancer-Related Fatigue among Adult Cancer Survivors: A Meta-Analysis

Brown

Huedo‐Medina²,

Pescatello³

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

356

265

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Background: The purpose of this meta-analysis was to explore the efficacy of exercise as a nonpharmacologic intervention to reduce cancer-related fatigue (CRF) among adult cancer survivors. We also investigated how different components of the exercise prescription (Ex R x ), methodologic considerations, and subject characteristics modulate CRF.Methods: A systematic search for randomized controlled trials was conducted using words related to cancer, exercise, and fatigue.Results: In total, 44 studies with 48 interventions qualified, including 3,254 participants of varying cancer types, stages of diagnosis, treatments, and exercise interventions. Cancer survivors in exercise interventions reduced their CRF levels to a greater extent than usual care controls, d þ ¼ 0.31 (95% CI ¼ 0.22-0.40), an effect that appeared to generalize across several types of cancer. CRF levels improved in direct proportion to the intensity of resistance exercise (b ¼ 0.60, P ¼ 0.01), a pattern that was stronger in higher quality studies (b ¼ 0.23, P < 0.05). CRF levels also reduced to a greater extent when interventions were theoretically driven (b ¼ 0.48, P < 0.001) or cancer survivors were older (b ¼ 0.24, P ¼ 0.04).Conclusions: Exercise reduced CRF especially in programs that involved moderate-intensity, resistance exercise among older cancer survivors and that were guided by theory.Impact: Our results indicate exercise interventions for adult cancer survivors should be multi-dimensional and individualized according to health outcome and cancer type. Cancer Epidemiol Biomarkers Prev; 20(1); 123-33.

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“…Decreased sleep quality without change during sleep is related to resistance to insulin and diabetes (8). Short and long sleeps are both related to metabolic syndrome (9) and short sleep is a risk factor for heart attack (10). Life quality and people's activity during waking hours are influenced by people's sleep quality (11).…”

Section: Introductionmentioning

confidence: 99%

The Association Between Sleep Quality and Metabolic Factors and Anthropometric Measurements

Khorasani¹,

Mohammadpoorasl²,

Javadi³

2016

Biotech Health Sci

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Background: Several studies have shown that sleep disorders may lead to metabolic or endocrine changes including insulin resistance, diabetes, obesity, cardiovascular disease and stroke. Objectives: The aim of this study was to investigate the association between sleep quality and metabolic factors and anthropometric measurements among personnel of a central petrochemical company in Tehran. Methods: This cross-sectional study was conducted on 400 personnel of a central petrochemical company in Tehran, during year 2015. Demographic information including age, gender, educational status, employment duration, working hours per day, marital status, smoking, medical history for disease and drug use, were collected by a questionnaire. Systolic and diastolic blood pressure and also height and weight were measured by standard methods and body mass index (BMI) was calculated. Pittsburg sleep quality index (PSQI) was performed to assess participants' sleep quality. Serum concentrations of fasting glucose and lipid profiles were measured by the related biochemical kits. Logistic regression analysis was used for multivariate adjusting of factors associated with sleep quality.

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Effect of Exercise on Biomarkers, Fatigue, Sleep Disturbances, and Depressive Symptoms in Older Women With Breast Cancer Receiving Hormonal Therapy

Abstract: Clinicians need to be aware that older women receiving hormonal treatment for their breast cancer may experience fatigue, sleep disturbances, and depressive symptoms. Homebased walking activity may reduce symptom severity in this group.

Cited by 181 publications

References 16 publications

A Randomized Trial of Aerobic Exercise and Sleep Quality in Lymphoma Patients Receiving Chemotherapy or No Treatments

A Randomized Trial of Aerobic Exercise and Sleep Quality in Lymphoma Patients Receiving Chemotherapy or No Treatments

Efficacy of Exercise Interventions in Modulating Cancer-Related Fatigue among Adult Cancer Survivors: A Meta-Analysis

The Association Between Sleep Quality and Metabolic Factors and Anthropometric Measurements

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