Effect of estrogen replacement therapy on lens epithelial cell apoptosis in an experimental rat model

Özçura, Fatih; Dündar, Sema Oruç; Çetin, Emel Dikicioǧlu; Beder, Nahit; Dündar, Mehmet

doi:10.1007/s10792-009-9327-6

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…In the presented study it was noted that oral administration of estradiol did not affect oxidative stress-related parameters in the lenses of ovariectomized rats, including the GSH content. Similar findings were made in another study, in which estradiol administered to estrogen-deficient rats revealed no effect on apoptosis rate in the lens epithelial cells, which was increased in the ovariectomized control rats [67]. Unlike the treatment with estradiol, administration of sinapic acid at both doses caused a significant increase in the estradiol concentration in the serum of the ovariectomized rats [21].…”

Section: Discussionsupporting

confidence: 80%

Rosmarinic and Sinapic Acids May Increase the Content of Reduced Glutathione in the Lenses of Estrogen-Deficient Rats

et al. 2019

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Oxidative stress is believed to be associated with both postmenopausal disorders and cataract development. Previously, we have demonstrated that rosmarinic and sinapic acids, which are diet-derived antioxidative phenolic acids, counteracted some disorders induced by estrogen deficiency. Other studies have shown that some phenolic acids may reduce cataract development in various animal models. However, there is no data on the effect of phenolic acids on oxidative stress markers in the lenses of estrogen-deficient rats. The study aimed to investigate whether administration of rosmarinic acid and sinapic acid affects the antioxidative abilities and oxidative damage parameters in the lenses of estrogen-deficient rats. The study was conducted on three-month-old female Wistar rats. The ovariectomized rats were orally treated with rosmarinic acid at doses of 10 and 50 mg/kg or sinapic acid at doses of 5 and 25 mg/kg, for 4 weeks. The content of reduced glutathione (GSH), oxidized glutathione and amyloid β1-42, as well as products of protein and lipid oxidation, were assessed. Moreover, the activities of superoxide dismutase, catalase, and some glutathione-related enzymes in the lenses were determined. Rosmarinic and sinapic acids in both doses resulted in an increase in the GSH content and glutathione reductase activity. They also improved parameters connected with protein oxidation. Since GSH plays an important role in maintaining the lens transparency, the increase in GSH content in lenses after the use of rosmarinic and sinapic acids seems to be beneficial. Therefore, both the investigated dietary compounds may be helpful in preventing cataract.

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Section: Discussionsupporting

confidence: 80%

Rosmarinic and Sinapic Acids May Increase the Content of Reduced Glutathione in the Lenses of Estrogen-Deficient Rats

et al. 2019

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“…Oestrogen and progesterone receptor mRNAs are present in retinal, ciliary body, iris and lens epithelial cells 10 . In an experimental rat model, oestrogen had a protective effect against the apoptosis of lens epithelial cells 11 . Moreover, some laboratory studies have suggested that oestrogen may provent cataract formation 12,13 …”

Section: Introductionmentioning

confidence: 99%

Menopausal hormone therapy and the risk of cataracts in postmenopausal women in South Korea

Yuk

Park

Sim

et al. 2023

Ophthalmic Physiologic Optic

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Age-related cataracts are a major cause of visual impairment and blindness worldwide, and cataract extraction is the most frequently performed eye surgery. 1 The occurrence and progression of cataracts are associated with various factors, including age, diabetes, hormones, drugs and ultraviolet light. 2 Menopause is the permanent cessation of menstruation that results from the loss of ovarian follicle development. 3 Most menopausal women experience vasomotor symptoms, including flushing, chills, anxiety, sleep disruption and palpitations. The pathophysiology of vasomotor symptoms remains poorly characterised. However, these symptoms are known to be caused by oestrogen withdrawal. 4 Hormone replacement therapy is widely used for the treatment of menopausal symptoms. 5 Systemic and transdermal oestrogen formulations are widely available for this form of treatment. Progesterone-containing formulations are also effective for treating vasomotor symptoms; however, they are not as effective as oestrogen. 6,7 Postmenopausal women have a higher prevalence of cataracts than men of a similar age. 8,9 The female sex hormone has been suggested to play a role in cataract formation and progression. 8 Oestrogen and progesterone receptor mRNAs are present in retinal, ciliary body, iris and lens epithelial cells. 10 In an experimental rat model, oestrogen had a protective effect against the apoptosis of lens epithelial cells. 11 Moreover, some laboratory studies have suggested that oestrogen may provent cataract formation. 12,13

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“…In an experimental rat model, estrogen exerted a protective effect against the apoptosis of lens epithelial cells [ 8 ]. Estrogen modulates the immune response by regulating the expression and secretion of inflammatory cytokines [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Hysterectomy for Benign Indications and Risk of Cataract Formation in South Korean Women

Kim

2023

Medicina

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Background and Objectives: Few studies have investigated the relationship between female reproductive hormones, especially estrogen, and the incidence of cataracts. This study sought to evaluate the effects of hysterectomy on the risk of lens opacity in Korean women. Materials and Methods: This retrospective cohort study utilized data collected from 2007 to 2020 for 255,576 postmenopausal women in the Korean National Health Insurance database. Participants were divided into those who did and did not undergo hysterectomy. The hysterectomy group was further divided into two subgroups according to the type of adnexal surgery performed. The prevalence of cataracts was then compared among the control, hysterectomy alone, and hysterectomy with adnexal surgery groups. Results: The control group included 137,999 participants who did not undergo hysterectomy, while the treatment group included 93,719 women who underwent hysterectomy alone or in combination with adnexal surgery. The incidence of cataracts was higher in the control group than in the treatment group, as demonstrated in a 1:1 propensity score-matching analysis adjusted for potential confounding variables. Conclusions: The incidence of cataracts was significantly lower in the group with hysterectomy than in the control group, but the difference was subtle. The current findings may aid in identifying the role of female reproductive hormones in cataract development.

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Effect of estrogen replacement therapy on lens epithelial cell apoptosis in an experimental rat model

Cited by 5 publications

References 28 publications

Rosmarinic and Sinapic Acids May Increase the Content of Reduced Glutathione in the Lenses of Estrogen-Deficient Rats

Rosmarinic and Sinapic Acids May Increase the Content of Reduced Glutathione in the Lenses of Estrogen-Deficient Rats

Menopausal hormone therapy and the risk of cataracts in postmenopausal women in South Korea

Hysterectomy for Benign Indications and Risk of Cataract Formation in South Korean Women

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