Effect of Escherichia coli infection on growth and protein metabolism in broiler chicks (Gallus domesticus)

Dietary plant extracts modulate gene expression profiles in ileal mucosa of weaned pigs after an Escherichia coli infection1

“…However, the infection increased the expression level of several genes related to amino sugar and nucleotide sugar metabolism. In addition, previous studies reported that the reduced growth caused by E. coli infection was related to suppressed protein synthesis and accumulation in the muscle tissues (Jepson et al, 1986;Tian and Baracos, 1989). Similarly, our clinical data showed E. coli infection reduced growth rate and feed efficiency (Liu et al, 2013), which may be related to the increased immune responses of pigs, decreased protein synthesis, or both.…”

Dietary plant extracts modulate gene expression profiles in ileal mucosa of weaned pigs after an Escherichia coli infection1

“…However, the infection increased the expression level of several genes related to amino sugar and nucleotide sugar metabolism. In addition, previous studies reported that the reduced growth caused by E. coli infection was related to suppressed protein synthesis and accumulation in the muscle tissues (Jepson et al, 1986;Tian and Baracos, 1989). Similarly, our clinical data showed E. coli infection reduced growth rate and feed efficiency (Liu et al, 2013), which may be related to the increased immune responses of pigs, decreased protein synthesis, or both.…”

Immunity lessons and actions: Practical implications

“…Those tissues not directly involved in the immune defense are either unaffected or increase their rates of protein degradation [21]. Skeletal muscle is the largest labile pool of amino acids, and infection increases protein degradation and the release of amino acids into plasma [27][28][29]. The release of amino acids from skeletal muscle plays an important role in supplying amino acid substrate for the synthesis of hepatic acute phase proteins involved in the host defense [23].…”

Dietary plant extracts modulate gene expression profiles in ileal mucosa of weaned pigs after an Escherichia coli infection1

“…However, the infection increased the expression level of several genes related to amino sugar and nucleotide sugar metabolism. In addition, previous studies reported that the reduced growth caused by E. coli infection was related to suppressed protein synthesis and accumulation in the muscle tissues (Jepson et al, 1986;Tian and Baracos, 1989). Similarly, our clinical data showed E. coli infection reduced growth rate and feed efficiency (Liu et al, 2013), which may be related to the increased immune responses of pigs, decreased protein synthesis, or both.…”

Immunity lessons and actions: Practical implications

“…Those tissues not directly involved in the immune defense are either unaffected or increase their rates of protein degradation [21]. Skeletal muscle is the largest labile pool of amino acids, and infection increases protein degradation and the release of amino acids into plasma [27][28][29]. The release of amino acids from skeletal muscle plays an important role in supplying amino acid substrate for the synthesis of hepatic acute phase proteins involved in the host defense [23].…”

Dietary plant extracts modulate gene expression profiles in ileal mucosa of weaned pigs after an Escherichia coli infection1

“…However, the infection increased the expression level of several genes related to amino sugar and nucleotide sugar metabolism. In addition, previous studies reported that the reduced growth caused by E. coli infection was related to suppressed protein synthesis and accumulation in the muscle tissues (Jepson et al, 1986;Tian and Baracos, 1989). Similarly, our clinical data showed E. coli infection reduced growth rate and feed efficiency (Liu et al, 2013), which may be related to the increased immune responses of pigs, decreased protein synthesis, or both.…”

Immunity lessons and actions: Practical implications

“…Those tissues not directly involved in the immune defense are either unaffected or increase their rates of protein degradation [21]. Skeletal muscle is the largest labile pool of amino acids, and infection increases protein degradation and the release of amino acids into plasma [27][28][29]. The release of amino acids from skeletal muscle plays an important role in supplying amino acid substrate for the synthesis of hepatic acute phase proteins involved in the host defense [23].…”