Effect of Eluting the 99Mo/99mTc Generator More than Once in 24 h on the Efficiency of the 99mTc-MIBI Complex

Hassanpour, Seyyed Hossein; Dehghani, Mohammad Amin; Elhamasl, R.; Lalehzari, Reza

doi:10.1134/s1066362219010119

Cited by 3 publications

(5 citation statements)

References 19 publications

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“…The ligand must be capable of coordination to 99m Tc. The coordination bond is not strong as covalent or ionic bond [21].To ensure the positive charge of complex, a technetium atom in a low oxidation state (+ which must be decomposed through labelling [23]. 99m Tc-MIBI is taken up by the cells of the myocardium in passive diffusion [24], and then seems in the cytosol which is localized in mitrochondria.…”

Section: Resultsmentioning

confidence: 99%

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The presentation of clinical results of radiolabelling of 99mTc-MIBI complex using ultrasound technique for myocardial perfusion SPECT scanning

2021

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Section: Resultsmentioning

confidence: 99%

“…Comparing to traditional approaches, ultrasound irradiation is more comfortable and simply monitored. Many chemical reactions were done in higher yield, shorter reaction time, and milder condition under ultrasound irradiation [21].Doroudi A et al…”

Section: Introductionmentioning

confidence: 99%

The presentation of clinical results of radiolabelling of 99mTc-MIBI complex using ultrasound technique for myocardial perfusion SPECT scanning

2021

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“…The ligand must be capable of coordination to 99m Tc. The coordination bond is not strong as covalent or ionic bond [21].To ensure the positive charge of complex, a technetium atom in a low oxidation state (+ 1) is reacted to monodentate isonitrile ligand to provide [Tc (-C = NR) 6] + with a hexacoordinated (octahedral) structure. Every carbon atom bound to the technetium possesses a non-paired electron (overlapping with the lone pair of adjacent nitrogen) ; hence, the technetium-sestamibi molecules are paramagnetic.…”

Section: Discussionmentioning

confidence: 99%

The Presentation of Clinical Results of Radiolabelling of 99mTc-MIBI Complex Using Ultrasound Technique for Myocardial Perfusion Scanning (MPS)

Hassanpour

Karami

2021

Preprint

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Background The initial objective and opinion of this study is introducing the clinical results of the 99mTc-MIBI complex radiolabelling utilizing ultrasound method as an approach for labeling MIBI kits with 99mTc instead of applying a boiling water bath as a usual and standard method. Materials and methods Twenty MIBI kits were bought for twenty patient volunteers. 555–3330 MBq (15–90 mCi) freshly eluted solution of Na+ 99mTcO4− was added to freeze-dry MIBI Kits. Moreover, ten kits were labeled applying ultrasound radiation method as an alternative approach (The vials were sonicated in thermo noted bath (Elma, P = 50 W, Germany) at 60\(\text{℃}\) and for 60 seconds), and other kits were provided applying boiling water bath method as a standard approach. Twenty patient volunteers (8 men and 12 women; age range 30–72, median 52.45 years) took part in this research. These people had gone to the hospital for myocardial perfusion imaging. These twenty volunteer patients were divided into two groups (every group contains ten people): group A (involving 3 men and 7 women with an age range from 36 to 67 years and a mean age of 51.7 years), and group B (involving 5 men and 5 women with an age range from 30 to 72 years and an average age of 50.3 years). The 99mTc-MIBI complex samples provided by ultrasound method were injected into group A subjects intravenously and group B received 99mTc-MIBI vials provided by boiling water bath approach (intravenous injection). In this research, the myocardial perfusion-SPECT was handled applying a rest-stress protocol which is done two isolated days for all volunteer patients. Results The results provided in this research applying radio-HPLC and ITLC, indicate that radio-labeling of MIBI vial with 99mTc can be provided with high effectiveness and appropriate acceptance applying ultrasound method as a novel approach. The imaging research applying SPECT indicated that the 99mTc-MIBI complex samples that were made ready applying ultrasound irradiation approach indicate very similar biodistribution in the heart, thyroid, lung, liver, gallbladder, kidneys, stomach, GI and bladder of the volunteer patients. Non-habitual aggregation of 99mTc-MIBI samples were not observed in our approach. Conclusions This research indicated that sonication approach can be proposed for providing 99mTc-MIBI radio-complex samples. The reaction time to provide radio-complex can be considerably decreased compared to the boiling water bath approach. This main development may decrease potential risk to the patient to inhibit any delay in emergency situations like acute therapy, especially for myocardial infarction patients in clinical practice.

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“…The ligand must be capable of coordination to 99mTc. The coordination bond is not strong as covalent or ionic bond [21].To ensure the positive charge of complex, a technetium atom in a low oxidation state (+1) is reacted to monodentate isonitrile ligand to provide [Tc (-C=NR) 6] + with a hexacoordinated (octahedral) structure. Every carbon atom bound to the technetium possesses a nonpaired electron (overlapping with the lone pair of adjacent nitrogen); hence, the technetium-sestamibi molecules are paramagnetic.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Presentation of Clinical Results of Radiolabelling of 99mtcMIBI Complex Using Ultrasound Technique for Myocardial Perfusion Scanning (MPS)

2021

IJNMRS

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The initial objective and opinion of this study is introducing the clinical results of the 99mTc-MIBI complex radiolabelling utilizing ultrasound method as an approach for labeling MIBI kits with 99mTc instead of applying a boiling water bath as a usual and standard method. The results provided in this research applying radio-HPLC and ITLC, indicate that radio-labeling of MIBI vial with 99mTc can be provided with high effectiveness and appropriate acceptance applying ultrasound method as a novel approach. The imaging research applying SPECT indicated that the 99mTc-MIBI complex samples that were made ready applying ultrasound irradiation approach indicate very similar biodistribution in the heart, thyroid, lung, liver, gallbladder, kidneys, stomach, GI and bladder of the volunteer patients. Non-habitual aggregation of 99mTc-MIBI samples were not observed in our approach. This research indicated that sonication approach can be proposed for providing 99mTc-MIBI radiocomplex samples. The reaction time to provide radio-complex can be considerably decreased compared to the boiling water bath approach. This main development may decrease potential risk to the patient to inhibit any delay in emergency situations like acute therapy, especially for myocardial infarction patients in clinical practice

show abstract

Effect of Eluting the 99Mo/99mTc Generator More than Once in 24 h on the Efficiency of the 99mTc-MIBI Complex

Cited by 3 publications

References 19 publications

The presentation of clinical results of radiolabelling of 99mTc-MIBI complex using ultrasound technique for myocardial perfusion SPECT scanning

The presentation of clinical results of radiolabelling of 99mTc-MIBI complex using ultrasound technique for myocardial perfusion SPECT scanning

The Presentation of Clinical Results of Radiolabelling of 99mTc-MIBI Complex Using Ultrasound Technique for Myocardial Perfusion Scanning (MPS)

The Presentation of Clinical Results of Radiolabelling of 99mtcMIBI Complex Using Ultrasound Technique for Myocardial Perfusion Scanning (MPS)

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