Effect of EGCG on lipid absorption and plasma lipid levels in rats

Raederstorff, Daniel; Schlachter, M.; Elste, Volker; Weber, Peter

doi:10.1016/s0955-2863(03)00054-8

Cited by 349 publications

(272 citation statements)

References 22 publications

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“…This is in accordance with previous data in mice (3,20) or in rats (10,12,21). The mechanism of cholesterol-reducing effect could be physicochemical, i.e.…”

Section: Vg Raneva and H Shimasakisupporting

confidence: 93%

Green Tea Catechins Decrease Lipid Peroxidation in Plasma and Organs of C57BL/6J Mice Fed Atherogenic Diet

Raneva

Shimasaki

2005

J. Oleo Sci.

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It is known that the active oxygen species could promote atherosclerosis, cancer, and aging. The antioxidants by scavenging free radicals or deactivating active oxygen species diminish the oxidation processes in vivo. We have shown that in artificial liposomal membranes the green tea catechins ( )-epigallocatechin gallate (EGCG), ( )-epicatechin gallate (ECG), ( )-epigallocatechin (EGC) and ( )-epicatechin (EC) are strong antioxidants acting by scavenging free radicals and/or regenerating a-tocopherol, the most abundant in LDL lipophilic antioxidant (1). Also we have demonstrated that oral supplementation of the most distributed green tea catechin and one of the most powerful polyphenol antioxidants EGCG preserves the inner rat Abstract: Green tea catechins (TC) have anti-obesity effects on atherosclerosis-susceptible mice fed atherogenic diet, but the antioxidant effect of the catechins at these conditions is not studied. Our aim is to show that green tea catechins have a favorable effect on plasma and organs lipid peroxidation parameters. For the purpose we have fed atherosclerosis-susceptible mice HF (30 %) diet containing TC (0.5 %). We have measured body weight, food intake, ferric-reducing ability of plasma (FRAP), total cholesterol and a-tocopherol concentrations in plasma, and lipid hydroperoxides concentrations in liver and small intestine, and compared them with these in control group fed HF diet. Also we have measured ECG and EGCG concentrations in plasma, liver, and small intestine of the mice fed TC. Our results show that green tea catechins' feeding reduces the body weight without affecting the food intake. TC group FRAP values are significantly different from these in the control group at all investigated periods. a-Tocopherol plasma concentrations in TC group have greater values than these in the control group. TC group liver and small intestine lipid hydroperoxides concentrations are lower than these in HF group. In conclusion, our results show that green tea catechins' feeding leads to catechins accumulation in plasma, liver, and small intestine which causes anti-lipid peroxidation effects in atherosclerosissusceptible mice.

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“…This is in accordance with previous data in mice (3,20) or in rats (10,12,21). The mechanism of cholesterol-reducing effect could be physicochemical, i.e.…”

Section: Vg Raneva and H Shimasakisupporting

confidence: 93%

Green Tea Catechins Decrease Lipid Peroxidation in Plasma and Organs of C57BL/6J Mice Fed Atherogenic Diet

Raneva

Shimasaki

2005

J. Oleo Sci.

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“…Although many studies have been explaining how tea influences dietary lipid metabolism, the detailed mechanism is not yet fully understood. It has been demonstrated that tea catechins, such as (À)-epicatechin, (À)-epigallocatechin, (À)-epicatechingallate and (À)-epigallocatechingallate(EGCG) activate hepatic lipid metabolism and result in the suppression of diet-induced obesity in rats (Chan et al, 1999;Yang et al, 2001;Murase et al, 2002;Raederstorff et al, 2003). Ikeda et al (1992) have found that EGCG, the major component of catechins in green tea, inhibits pancreatic lipase in vitro and cholesterol absorption, and lymphatic TG absorption in rats.…”

Section: Discussionmentioning

confidence: 99%

Polyphenol-enriched oolong tea increases fecal lipid excretion

Kusumoto

Abe

et al. 2006

Eur J Clin Nutr

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Objective: To assess possibility of polyphenol-enriched oolong tea to reduce dietary lipid absorption in humans. Design: Twelve healthy adult subjects, three males and nine females, aged (mean7s.d.) 22.071.8 years, respectively, were randomly divided into two groups. The participants were followed a double-blind placebo-controlled crossover design, including 7-day washout periods and 10-day treatment periods. During the treatment periods, subjects were given about 38 g of lipids from potato chips (19 g each within 30 min after lunch and dinner) and total 750 ml beverages (placebo-or polyphenolenriched oolong tea) at three meals. Blood samples were collected for biochemical examination at days 8, 18, 25 and 35 of the study period. On the last 3 days of each treatment period, feces were collected to measure the excretion of lipids. Results: Lipid excretion into feces was significantly higher in the polyphenol-enriched oolong tea period (19.3712.9 g/3day) than in the placebo period (9.477.3 g/3day) (Po0.01). Cholesterol excretion tended to increase in polyphenol-enriched oolong tea period (1.871.2 g/3day) compared with that of placebo (1.270.6 g/3day) (P ¼ 0.056). Conclusions:The results of this study indicated that polyphenol-enriched oolong tea could increase lipid excretion into feces when subjects took high-lipid diet.

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“…As we did not analyse faeces composition, it is not clear if this is related to a decreased intestinal fat or carbohydrate extraction, but previous studies indicate that EGCG decreases fat absorption. 29 On the other hand, it has also been reported that tea catechins including EGCG could inhibit the sodiumdependent glucose transporter. 30 If the reduced energy absorption is taken into account, EGCG resulted in a slightly (but not significantly) reduced total energy digestion of about 200 kJ throughout the 4-week treatment period (control: 2790 kJ, EGCG 0.5%: 2565 kJ, EGCG 1%: 2587 kJ).…”

Section: Egcg Prevents Obesity S Klaus Et Almentioning

confidence: 99%

Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation

et al. 2005

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OBJECTIVE:To examine the antiobesity effect of epigallocatechin gallate (EGCG), a green tea bioactive polyphenol in a mouse model of diet-induced obesity. METHODS: Obesity was induced in male New Zealand black mice by feeding of a high-fat diet. EGCG purified from green tea (TEAVIGOt) was supplemented in the diet (0.5 and 1%). Body composition (quantitative magnetic resonance), food intake, and food digestibility were recorded over a 4-week period. Animals were killed and mRNA levels of uncoupling proteins (UCP1-3), leptin, malic enzyme (ME), stearoyl-CoA desaturase-1 (SCD1), glucokinase (GK), and pyruvate kinase (PK) were analysed in different tissues. Also investigated were acute effects of orally administered EGCG (500 mg/kg) on body temperature, activity (transponders), and energy expenditure (indirect calorimetry). RESULTS: Dietary supplementation of EGCG resulted in a dose-dependent attenuation of body fat accumulation. Food intake was not affected but faeces energy content was slightly increased by EGCG, indicating a reduced food digestibility and thus reduced long-term energy absorption. Leptin and SCD1 gene expression in white fat was reduced but SCD1 and UCP1 expression in brown fat was not changed. In liver, gene expression of SCD1, ME, and GK was reduced and that of UCP2 increased. Acute oral administration of EGCG over 3 days had no effect on body temperature, activity, and energy expenditure, whereas respiratory quotient during night (activity phase) was decreased, supportive of a decreased lipogenesis and increased fat oxidation. CONCLUSIONS: Dietary EGCG attenuated diet-induced body fat accretion in mice. EGCG apparently promoted fat oxidation, but its fat-reducing effect could be entirely explained by its effect in reducing diet digestibility.

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Effect of EGCG on lipid absorption and plasma lipid levels in rats

Cited by 349 publications

References 22 publications

Green Tea Catechins Decrease Lipid Peroxidation in Plasma and Organs of C57BL/6J Mice Fed Atherogenic Diet

Green Tea Catechins Decrease Lipid Peroxidation in Plasma and Organs of C57BL/6J Mice Fed Atherogenic Diet

Polyphenol-enriched oolong tea increases fecal lipid excretion

Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation

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