volume 29, issue 1, P109-123 2012
DOI: 10.3233/jad-2012-110426
View full text

Abstract: It is proposed that the prodromal phase of Alzheimer's disease is associated with additional brain activation in key regions involved in memory, reflecting compensatory brain plasticity. Very little is known, however, about the evolution of these compensatory mechanisms as the brain acquires more damages. We conducted an fMRI memory study measuring brain activation related to old/new (item recognition) and intact/rearranged (associative recognition) word-pair recognition paradigms in 26 persons with mild cogni…

Expand abstract