Effect of Dimethyl Sulfoxide on Island Flap Perfusion and Survival in Rats

Caspase Inhibition Enhances Ischemic Tolerance of Fasciocutaneous Flaps

“…The critical primary ischemia time for the animals treated with DMSO was significantly improved compared with those treated with saline. This was not surprising because previous studies have shown DMSO improves flap survival 13 . DMSO is thought to act as a free radical scavenger, thus decreasing cellular damage from oxygen radicals during reperfusion.…”

“…This was not surprising because previous studies have shown DMSO improves flap survival. 13 DMSO is thought to act as a free radical scavenger, thus decreasing cellular damage from oxygen radicals during reperfusion.…”

Topical Dimethyl Sulfoxide for Congested Nipple–areolar Complexes in Breast Surgery: A Pilot Study

“…[18][19][20] Animal studies revealed that DMSO possessed membrane penetrating, antiinflammatory, analgesic, and vasodilatory properties, and a number of rat studies demonstrated circulatory improvement in pedicle flaps treated with DMSO solution. 10,[21][22][23] In veterinary medicine, DMSO has long been used in topical and intravenous forms to treat a variety of ailments, including joint swelling, 24 spinal cord injury, 25 laminitis (hoof inflammation), 26 muscle trauma, 27 and hypoxic damage to various tissues following infarction. 28 In 1996, a randomized controlled trial by Rand-Luby et al showed that application of topical 60% DMSO to human mastectomy skin flaps reduced the average area of flap ischemia by approximately 63%.…”

Effectiveness of Dimethylsulfoxide on the Survival and Volume Preservation of Autologous Fat Graft Tissue: A Preliminary Study

“…Recently, cutaneously applied and/or parenterally administered DMSO has been used postoperatively to improve skin flap survival in plastic surgery because it increases flap perfusion. 17,18,27,32,33 In this study, the ability of DMSO to preserve fat graft volumes and viability was examined together with its antiinflammatory effects and its positive effects on vascularization. The efficacy of cutaneously applied versus intraperitoneally injected DMSO was determined.…”