Effect of dietary zinc intake on the hematological profile of the rat

Intestinal Inflammation in Rats Induces Metallothionein in Colonic Submucosa

“…Zn status also affected the CBC; the red blood cell count and the hemoglobin levels were higher due to Zn and energy deficiency (ZD and PF rats, respectively) compared to the control and Zn supplemented groups (Table 3 ) and in agreement with previous work, suggesting altered hematological development due to Zn deficiency in young rats [ 36 ]. In contrast, El-Hendy et al [ 37 ] found that longer term Zn deficiency in growing rats produced a 17% decline in the hemoglobin levels and they attributed it to a reduction in the rate of red blood cell formation.…”

Intestinal Inflammation in Rats Induces Metallothionein in Colonic Submucosa

“…Zn status also affected the CBC; the red blood cell count and the hemoglobin levels were higher due to Zn and energy deficiency (ZD and PF rats, respectively) compared to the control and Zn supplemented groups (Table 3 ) and in agreement with previous work, suggesting altered hematological development due to Zn deficiency in young rats [ 36 ]. In contrast, El-Hendy et al [ 37 ] found that longer term Zn deficiency in growing rats produced a 17% decline in the hemoglobin levels and they attributed it to a reduction in the rate of red blood cell formation.…”

Successful Clozapine Treatment for Treatment‐Resistant Schizophrenia With Zinc Deficiency Severe Anemia: A Case Report

“…Many studies, especially in women of reproductive age [ 15 , 16 ] and preschool‐aged children [ 17 ], have shown that zinc deficiency is associated with iron deficiency anemia. Several experiments in rats have revealed that coexisting zinc and iron deficiency caused anemia, whereas zinc deficiency alone does not [ 18 , 19 ]. However, a few reports about zinc deficiency anemia without iron deficiency suggest that zinc deficiency alone could cause anemia, as seen in our current case [ 20 , 21 , 22 ].…”

Zinc-Deficiency Induced Changes in the Distribution of Rat White Blood Cells

“…Increased actions of the number of granulocytes may be at least partially physiologic, representing a shift in the ratio of freely circulating and marginal portions of the intravascular pool. The increase of circulatory granulocytes may also reflect a pathologic state such as infection or tissue necrosis, where the input of granulocytes into the intravascular compartment from the bone marrow storage pool increases (8). From these results and suggestions, although the mechanism of its action is unknown, an investigation of the kinetics of the production and compartment of numbers of granulocytes during the zincdeficiency will be necessary (40).…”

“…Inadequate intake of zinc is accompanied by a number of clinical manifestations, which may prove fatal unless treated ( 10 ). Severe zinc-deficiency is characterized by severely depressed immune functions, frequent infections, bullous pustular dermatitis, diarrhea, alopecia, increased susceptibility to infections and mental disturbances ( 8 ). Even mild zinc-deficiency, which is widely spread in contrast to severe zinc-deficiency, depresses the immunity of humans ( 13 ).…”

Intestinal Inflammation in Rats Induces Metallothionein in Colonic Submucosa

“…Zn status also affected the CBC; the red blood cell count and the hemoglobin levels were higher due to Zn and energy deficiency (ZD and PF rats, respectively) compared to the control and Zn supplemented groups (Table 3 ) and in agreement with previous work, suggesting altered hematological development due to Zn deficiency in young rats [ 36 ]. In contrast, El-Hendy et al [ 37 ] found that longer term Zn deficiency in growing rats produced a 17% decline in the hemoglobin levels and they attributed it to a reduction in the rate of red blood cell formation.…”

Successful Clozapine Treatment for Treatment‐Resistant Schizophrenia With Zinc Deficiency Severe Anemia: A Case Report

“…Many studies, especially in women of reproductive age [ 15 , 16 ] and preschool‐aged children [ 17 ], have shown that zinc deficiency is associated with iron deficiency anemia. Several experiments in rats have revealed that coexisting zinc and iron deficiency caused anemia, whereas zinc deficiency alone does not [ 18 , 19 ]. However, a few reports about zinc deficiency anemia without iron deficiency suggest that zinc deficiency alone could cause anemia, as seen in our current case [ 20 , 21 , 22 ].…”

Zinc-Deficiency Induced Changes in the Distribution of Rat White Blood Cells

“…Increased actions of the number of granulocytes may be at least partially physiologic, representing a shift in the ratio of freely circulating and marginal portions of the intravascular pool. The increase of circulatory granulocytes may also reflect a pathologic state such as infection or tissue necrosis, where the input of granulocytes into the intravascular compartment from the bone marrow storage pool increases (8). From these results and suggestions, although the mechanism of its action is unknown, an investigation of the kinetics of the production and compartment of numbers of granulocytes during the zincdeficiency will be necessary (40).…”

“…Inadequate intake of zinc is accompanied by a number of clinical manifestations, which may prove fatal unless treated ( 10 ). Severe zinc-deficiency is characterized by severely depressed immune functions, frequent infections, bullous pustular dermatitis, diarrhea, alopecia, increased susceptibility to infections and mental disturbances ( 8 ). Even mild zinc-deficiency, which is widely spread in contrast to severe zinc-deficiency, depresses the immunity of humans ( 13 ).…”

Intestinal Inflammation in Rats Induces Metallothionein in Colonic Submucosa

“…Zn status also affected the CBC; the red blood cell count and the hemoglobin levels were higher due to Zn and energy deficiency (ZD and PF rats, respectively) compared to the control and Zn supplemented groups (Table 3 ) and in agreement with previous work, suggesting altered hematological development due to Zn deficiency in young rats [ 36 ]. In contrast, El-Hendy et al [ 37 ] found that longer term Zn deficiency in growing rats produced a 17% decline in the hemoglobin levels and they attributed it to a reduction in the rate of red blood cell formation.…”

Successful Clozapine Treatment for Treatment‐Resistant Schizophrenia With Zinc Deficiency Severe Anemia: A Case Report

“…Many studies, especially in women of reproductive age [ 15 , 16 ] and preschool‐aged children [ 17 ], have shown that zinc deficiency is associated with iron deficiency anemia. Several experiments in rats have revealed that coexisting zinc and iron deficiency caused anemia, whereas zinc deficiency alone does not [ 18 , 19 ]. However, a few reports about zinc deficiency anemia without iron deficiency suggest that zinc deficiency alone could cause anemia, as seen in our current case [ 20 , 21 , 22 ].…”

Zinc-Deficiency Induced Changes in the Distribution of Rat White Blood Cells

“…Increased actions of the number of granulocytes may be at least partially physiologic, representing a shift in the ratio of freely circulating and marginal portions of the intravascular pool. The increase of circulatory granulocytes may also reflect a pathologic state such as infection or tissue necrosis, where the input of granulocytes into the intravascular compartment from the bone marrow storage pool increases (8). From these results and suggestions, although the mechanism of its action is unknown, an investigation of the kinetics of the production and compartment of numbers of granulocytes during the zincdeficiency will be necessary (40).…”

“…Inadequate intake of zinc is accompanied by a number of clinical manifestations, which may prove fatal unless treated ( 10 ). Severe zinc-deficiency is characterized by severely depressed immune functions, frequent infections, bullous pustular dermatitis, diarrhea, alopecia, increased susceptibility to infections and mental disturbances ( 8 ). Even mild zinc-deficiency, which is widely spread in contrast to severe zinc-deficiency, depresses the immunity of humans ( 13 ).…”