Effect of Dietary Vitamin E and Selenium Supplementation on Physiological Responses and Reproductive Performance in Holstein Friesian Bulls during Humid Hot Summer

Butt, Mahboob Ahmed

doi:10.29261/pakvetj/2019.053

Cited by 8 publications

(6 citation statements)

References 20 publications

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“…Similar findings were also observed by the same group of researchers in 2015 [131], where the dietary supplementation of Se-yeast (6 μg per kg) in combination with vitamin E (5 mg per kg) for 60 days resulted in the improved sperm quality parameters such as total sperm count, concentration, morphology, and motility scores in clinically healthy dogs with reduced fertility [131]. Similarly, Butt et al [132] demonstrated that Se (supplemented as 3g Selemax ® ) in combination with vitamin E significantly improved the ejaculate and sperm quality parameters, and increased the concentration of testosterone in Holstein Friesian bulls maintained in a hot and humid environment [132]. Additionally, Ghorbani et al [133] evaluated the effects of dietary Se (0.3 mg/kg), Zn (40 mg/kg) and their combination on reproductive performance in Sanjabi rams during the breeding season.…”

Section: Role Of Selenium In Male Reproductionsupporting

confidence: 75%

Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

et al. 2019

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Selenium (Se) is an important trace mineral having many essential roles at the cellular and organismal levels in animal and human health. The biological effects of Se are mainly carried out by selenoproteins (encoded by 25 genes in humans and 24 in mice). As an essential component of selenoproteins, Se performs structural and enzymic roles; in the latter context it is well known for its catalytic and antioxidative functions. Studies involving different animal models have added great value to our understanding regarding the potential implications of Se and selenoproteins in mammalian fertility and reproduction. In this review, we highlight the implications of selenoproteins in male fertility and reproduction followed by the characteristic biological functions of Se and selenoproteins associated with overall male reproductive function. It is evident from observations of past studies (both animal and human) that Se is essentially required for spermatogenesis and male fertility, presumably because of its vital role in modulation of antioxidant defense mechanisms and other essential biological pathways and redox sensitive transcription factors. However, bearing in mind the evidences from mainstream literature, it is also advisable to perform more studies focusing on the elucidation of additional roles played by the peculiar and canonical selenoproteins i.e., glutathione peroxidase 4 (GPX4) and selenoprotein P (SELENOP) in the male reproductive functions. Nevertheless, search for the elucidation of additional putative mechanisms potentially modulated by other biologically relevant selenoproteins should also be included in the scope of future studies. However, as for the implication of Se in fertility and reproduction in men, though a few clinical trials explore the effects of Se supplementation on male fertility, due to inconsistencies in the recruitment of subjects and heterogeneity of designs, the comparison of such studies is still complicated and less clear. Therefore, further research focused on the roles of Se and selenoproteins is awaited for validating the evidences at hand and outlining any therapeutic schemes intended for improving male fertility. As such, new dimensions could be added to the subject of male fertility and Se supplementation.

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Section: Role Of Selenium In Male Reproductionsupporting

confidence: 75%

Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

et al. 2019

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“…Similar improvements in semen volume and sperm concentration have been reported when antioxidants are supplemented in rams [ 41 , 42 ], goat bucks [ 43 ], and rabbits [ 44 ]. However, some authors reported no effect of antioxidant supplementation on the semen volume and sperm concentration in rams [ 45 , 46 ] and bulls [ 47 ]. Different results following the supplementation with antioxidants on semen volume and sperm concentration could be referred to the variations in the level or the duration of supplementation and the antioxidant type used.…”

Section: Resultsmentioning

confidence: 99%

Effect of Acacia mearnsii Tannin Extract Supplementation on Reproductive Performance and Oxidative Status of South African Mutton Merino Rams

Ahmed

Lehloenya

Mphaphathi

et al. 2021

Animals

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We investigated the supplementation effects of Acacia mearnsii tannin extract (TE) and encapsulated tannin extract (ETE) on reproductive performance and oxidative status of South African Mutton Merino rams. We also observed the season effect on the testicular measurements. Thirty rams were divided into five groups: 0.0 g TE (control), 1.5 g TE, 3 g TE, 1.5 g ETE, and 3 g ETE supplemented daily for 16 weeks transiting from autumn to winter. Bodyweight and testicular measurements were recorded biweekly. Semen and blood samples were collected weekly during the last five weeks of supplementation. Results showed that the increase in the ETE from 1.5 to 3 g increased the testicular length and sperm concentration, as well as decreased the percentages of low and non-progressive spermatozoa (p<0.05). Simultaneously, the increase in the TE from 1.5 to 3 g decreased semen volume and elevated the percentage of abnormal sperm (p<0.05). The results suggest that the encapsulation of TE affords the maximum benefit of the TE on the sperm quality. Treatments did not affect the hormonal and oxidative status. Testicular measurements were significantly higher in autumn compared to winter. The plasma level of cortisol significantly correlates negatively with sperm motility, viability, and acrosome integrity.

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“…48 In vitro experiments have shown that vitamin E can effectively scavenge reactive oxygen, while in vivo studies have found that vitamin E supplementation can improve semen quality. [49][50][51] In addition, vitamin E supplementation can reduce sperm DNA fragmentation 52 and benefit to in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). 53,54 It was believed that vitamin E has a role in promoting the synthesis of testosterone by Leydig cells, 55 The viewpoints of TCM define male infertility as a multifactorial disease whose pathogenesis is associated with kidney, liver and spleen disorders.…”

Section: Discussionmentioning

confidence: 99%

Vitamins combined with traditional Chinese medicine for male infertility: A systematic review and meta‐analysis

Wang

et al. 2020

Andrology

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Background Male infertility is a tough problem in medicine. This article aims to provide the latest evidence for the efficacy and safety of traditional Chinese medicine (TCM) combined with vitamins in the treatment of male infertility. Method All randomized controlled trials (RCTs) that used TCM combined with vitamins for male infertility treatment were included in databases of China National Knowledge Infrastructure (CNKI), Wanfang, VIP Database, China Biology Medicine disc (CBM), MEDLINE, EMBASE, and Cochrane Library. The quality of the included articles was evaluated using the Cochrane Reviewer's Handbook 5.3, and meta‐analysis was performed using Stata 15. Results A total of 14 eligible studies with 1488 patients were included in this meta‐analysis. The results suggested that, compared with vitamin E or vitamin E + C alone, combination of TCM with vitamins increased significantly sperm concentration, sperm motility, sperm viability, liquefaction time of semen, the activity of acrosome enzyme, and the pregnancy rate of patients with male infertility. Three kinds of TCM (Shengjing capsule, Huanshao capsule, and compound Xuanju capsule) showed significant improvement for male infertility in terms of pregnancy rate, sperm concentration, or sperm motility. In addition, the results of the publication bias test demonstrated that no significant bias occurred. Conclusion Traditional Chinese medicine combined with vitamins has significant efficacy in the treatment of male infertility with no increase in side effects. The specific implementing regulations still need more long‐term, multicenter, randomized, and double‐blind clinical trials.

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Effect of Dietary Vitamin E and Selenium Supplementation on Physiological Responses and Reproductive Performance in Holstein Friesian Bulls during Humid Hot Summer

Cited by 8 publications

References 20 publications

Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

Role of Selenium and Selenoproteins in Male Reproductive Function: A Review of Past and Present Evidences

Effect of Acacia mearnsii Tannin Extract Supplementation on Reproductive Performance and Oxidative Status of South African Mutton Merino Rams

Vitamins combined with traditional Chinese medicine for male infertility: A systematic review and meta‐analysis

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