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“…Similar results have been observed in mouse models supplemented with vitamin E before primary sensitization [50]. Supplementation with vitamin E before primary sensitization in the murine model of toluene-diisocyanate (TDI) induced nasal allergy, significantly attenuated the outwardly observable indicators of nasal allergy, and reduced mitogen-induced lymphoproliferative, IL-4 and IL-5 responses [51]. Similar results have been reported in nasally TDI sensitized guinea-pigs supplemented with vitamin E and C [52].…”
Section: Animal Modelssupporting
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“…Similar results have been observed in mouse models supplemented with vitamin E before primary sensitization [50]. Supplementation with vitamin E before primary sensitization in the murine model of toluene-diisocyanate (TDI) induced nasal allergy, significantly attenuated the outwardly observable indicators of nasal allergy, and reduced mitogen-induced lymphoproliferative, IL-4 and IL-5 responses [51]. Similar results have been reported in nasally TDI sensitized guinea-pigs supplemented with vitamin E and C [52].…”
Section: Animal Modelssupporting
“…Since it has been reported that vitamin E did not down‐regulate IL‐2 levels in a mouse allergy model 16 but instead even restored IL‐2 levels reduced during retrovirus infection in murine AIDS models 15, 19 and increased IL‐2 production in old mice 20 and healthy older adults 21, we also examined the effect of vitamin E on IL‐2 mRNA levels by quantitative real‐time PCR. The IL‐2 mRNA expression levels were much higher (more than 100‐fold) than the levels of IL‐4 mRNA (Fig.…”
Section: Resultsmentioning
“…Recently, a study on the relation between dietary vitamin E intake and serum IgE concentrations and atopy, from a random sample of 2,633 adults, revealed that higher concentrations of vitamin E (but not vitamin C) intake were associated with lower serum IgE levels and a lower frequency of allergen sensitization 14. Significant reduction of IgE and IL‐4 levels was also observed in mice whose diet was supplemented with vitamin E 15, 16. Although the effect of vitamin E on IgE and atopy has been reported, the molecular mechanism by which vitamin E suppresses IgE expression has not been investigated.…”
Section: Introductionmentioning
“…In a murine nasal allergy model, Zheng et al showed that supplementation with a diet containing 535 mg aT per kg for 4 weeks significantly reduced quantifiable nasal symptoms compared with a diet containing normal levels of aT (Zheng et al, 1999). In contrast to the human studies discussed before aT supplementation also led to a significant decrease in lymphocyte proliferation, serum IgE levels and production of the Th2 cytokines IL-4 and IL-5 in these animals.…”
Section: Animal Studiesmentioning