Effect of dietary supplementation with n-3 fatty acids on clinical manifestations of psoriasis

Abstract

In a double-blind, block randomized study we investigated the effect of dietary supplementation with eicosapentaenoic acid in patients with psoriasis. The experimental group received 10 g of fish oil daily containing approximately 1.8 g eicosapentaenoic acid, while the controls were given an isoenergetic amount of olive oil. We found no significant change in the clinical manifestations of psoriasis in either group after 8 weeks of treatment. In the experimental group, the amount of n-3 fatty acids in serum phospholipids was significantly increased at the end of trial as compared to pre-treatment values, whereas the level of n-6 fatty acids was decreased.

The role of lipids in psoriasis

“…Adil et al observed a 50% reduction in the PASI score in nearly half of patients after 12 weeks of omega-3 supplementation at a dose of 1.8 g/day [92]. However, not all data are consistent, for example in terms of reduction of individual PASI components or the efficacy of supplementation as such [82,93].…”

Effect of omega‐3 fatty acids on disease severity in patients with psoriasis: A systematic review

“…Veale et al 6 reported no significant changes in articular index or skin itch at the end of the study, yet the subjects in the active treatment group had significantly more skin itch at the beginning (P = 0.03), thus suggesting the implementation of n-3 PUFA may be helpful for skin itch. Although Bjorneboe et al 14 did not find any significant difference between both groups, the total n-3 PUFA in serum phospholipids was significantly increased as compared to pre-treatment values while causing a significant fall in the AA and linoleic acid content of serum phospholipids. Madland et al 15 reported a significant improvement of joint pain in patients with psoriatic arthritis in both intervention and control groups; only improvement of joint swelling was noted in the intervention group.…”

“…LTB4 was found to have significantly decreased in the treatment group (P < 0.03) but not in the control group. The other six studies 5,6,14,15,17,18 reported no significant reduction in scaling, erythema, area involved or thickness. Gupta et al 5 reported the mean time period elapsed before the psoriasis worsened to pre-therapy severity was 4.9 AE 0.5 weeks in the intervention group and 4.5 AE 0.6 weeks in the control group (P = 0.4).…”

“…A total of 720 articles were excluded because they were not randomized controlled trials or observational studies (427 articles), did not involve dietary or pharmacologic interventions with n-3 fatty acids (210 articles), did not perform a comparison (65 articles), or did not include the outcome of interest (18 articles). Eleven randomized controlled trials [4][5][6][11][12][13][14][15][16][17][18] and one open-label controlled observational study 19 were included, and the data of all 12 studies were extracted. The characteristics of the extracted studies are outlined in Table 1.…”

Psoriasis and Nutrition Interactions

“…Yapılan bir çalışmada sekiz hafta boyunca on üç hastaya 1,8 g/gün EPA içeren balık yağı ve on dört hastaya zeytinyağı verilmiştir. EPA verilen grupta serum fosfolipitlerinde artış görülürken, klinik parametrelerinden eritem, infiltrasyon, deskumasyon, hastalığın vücudu kaplama alanı, PAŞİ ve sübjektif skorlarında anlamlı bir değişiklik saptanmamıştır (14). Yapılan bir çiftkör çalışmada n-3 yağ asitlerinden zengin balık yağı ve n-6 yağ asitlerinden zengin yağ ile yapılan kombine tedavi sonrasında kronik stabil plaklı psoriasisli hastaların klinik bulgularında hiçbir değişiklik görülmemiştir (15).…”