Effect of dietary selenium on the metabolism of aflatoxin B1 in turkeys

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

“…The exact mechanisms of the protective role of Se on the suppression of humoral immune response of cecal tonsils caused by AFB 1 needs to elucidate by further research. However, it may be partially associated with following factors: (1) Se could improve the AFB 1 -induced impairment of bursa of Fabricius [ 19 ]; (2) Se could increase immunoglobulin synthesis and enhance B-cell function [ 54 , 55 ]; (3) Se could enhance conjugation of aflatoxins thereby increasing excretion of aflatoxins [ 56 ], and repress the formation of AFB 1 -DNA adducts [ 57 ]; (4) the protective effect of Se was mediated through a cellular mechanism related to glutathione detoxification pathways [ 52 ].…”

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

“…The exact mechanisms of the protective role of Se on the suppression of humoral immune response of cecal tonsils caused by AFB 1 needs to elucidate by further research. However, it may be partially associated with following factors: (1) Se could improve the AFB 1 -induced impairment of bursa of Fabricius [ 19 ]; (2) Se could increase immunoglobulin synthesis and enhance B-cell function [ 54 , 55 ]; (3) Se could enhance conjugation of aflatoxins thereby increasing excretion of aflatoxins [ 56 ], and repress the formation of AFB 1 -DNA adducts [ 57 ]; (4) the protective effect of Se was mediated through a cellular mechanism related to glutathione detoxification pathways [ 52 ].…”

Species Differences in the Biotransformation of Aflatoxin B1: Primary Determinants of Relative Carcinogenic Potency in Different Animal Species

“…Several studies have also shown that direct conjugation of AFB1, or more likely oxidative metabolites of AFB1, with glucuronic acid and sulfate, occurred both in vivo and in hepatocyte cultures [ 191 , 192 , 197 , 198 , 199 ]. Dalezeos and Wogan [ 194 ] reported that AFP1 and its glucuronide and sulfate conjugates were found in the urine of Rhesus monkeys given AFB1.…”

Selenium and the health status, production results, and product quality in poultry

“…The protective effect of Se against mycotoxins in chickens and duck was shown in terms of supporting the immune organs weight such as bursa of Fabricius, down regulating the hepatic mitochondrial apoptotic proteins including caspase-3 as well as promoting the concentration of immunoglobulins such as IgA, IgG, and IgM (Chen et al, 2014). Gregory and Edds (1984) reported that different levels of Se dietary supplementation alleviated the toxic effects of AFB1 by preventing damage in the liver of turkeys.…”

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

“…The exact mechanisms of the protective role of Se on the suppression of humoral immune response of cecal tonsils caused by AFB 1 needs to elucidate by further research. However, it may be partially associated with following factors: (1) Se could improve the AFB 1 -induced impairment of bursa of Fabricius [ 19 ]; (2) Se could increase immunoglobulin synthesis and enhance B-cell function [ 54 , 55 ]; (3) Se could enhance conjugation of aflatoxins thereby increasing excretion of aflatoxins [ 56 ], and repress the formation of AFB 1 -DNA adducts [ 57 ]; (4) the protective effect of Se was mediated through a cellular mechanism related to glutathione detoxification pathways [ 52 ].…”

Species Differences in the Biotransformation of Aflatoxin B1: Primary Determinants of Relative Carcinogenic Potency in Different Animal Species

“…Several studies have also shown that direct conjugation of AFB1, or more likely oxidative metabolites of AFB1, with glucuronic acid and sulfate, occurred both in vivo and in hepatocyte cultures [ 191 , 192 , 197 , 198 , 199 ]. Dalezeos and Wogan [ 194 ] reported that AFP1 and its glucuronide and sulfate conjugates were found in the urine of Rhesus monkeys given AFB1.…”

Selenium and the health status, production results, and product quality in poultry

“…The protective effect of Se against mycotoxins in chickens and duck was shown in terms of supporting the immune organs weight such as bursa of Fabricius, down regulating the hepatic mitochondrial apoptotic proteins including caspase-3 as well as promoting the concentration of immunoglobulins such as IgA, IgG, and IgM (Chen et al, 2014). Gregory and Edds (1984) reported that different levels of Se dietary supplementation alleviated the toxic effects of AFB1 by preventing damage in the liver of turkeys.…”

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

“…The exact mechanisms of the protective role of Se on the suppression of humoral immune response of cecal tonsils caused by AFB 1 needs to elucidate by further research. However, it may be partially associated with following factors: (1) Se could improve the AFB 1 -induced impairment of bursa of Fabricius [ 19 ]; (2) Se could increase immunoglobulin synthesis and enhance B-cell function [ 54 , 55 ]; (3) Se could enhance conjugation of aflatoxins thereby increasing excretion of aflatoxins [ 56 ], and repress the formation of AFB 1 -DNA adducts [ 57 ]; (4) the protective effect of Se was mediated through a cellular mechanism related to glutathione detoxification pathways [ 52 ].…”

Species Differences in the Biotransformation of Aflatoxin B1: Primary Determinants of Relative Carcinogenic Potency in Different Animal Species

“…Several studies have also shown that direct conjugation of AFB1, or more likely oxidative metabolites of AFB1, with glucuronic acid and sulfate, occurred both in vivo and in hepatocyte cultures [ 191 , 192 , 197 , 198 , 199 ]. Dalezeos and Wogan [ 194 ] reported that AFP1 and its glucuronide and sulfate conjugates were found in the urine of Rhesus monkeys given AFB1.…”

Selenium and the health status, production results, and product quality in poultry

“…The protective effect of Se against mycotoxins in chickens and duck was shown in terms of supporting the immune organs weight such as bursa of Fabricius, down regulating the hepatic mitochondrial apoptotic proteins including caspase-3 as well as promoting the concentration of immunoglobulins such as IgA, IgG, and IgM (Chen et al, 2014). Gregory and Edds (1984) reported that different levels of Se dietary supplementation alleviated the toxic effects of AFB1 by preventing damage in the liver of turkeys.…”