Effect of dietary L-tryptophan on the survival, immune response and gut microbiota of the Chinese mitten crab, Eriocheir sinensis

Yang, Xiaozhen; Xu, Minjie; Huang, Genyong; Zhang, Cong; Pang, Yangyang; Cheng, Yongxu

doi:10.1016/j.fsi.2018.10.076

Cited by 37 publications

(17 citation statements)

References 54 publications

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“…Nevertheless, the addition of andrographolide was shown to distinctly increase the percentages of Fusobacteria and Firmicutes, concurrent with a significant decrease in those of Cyanobacteria and Proteobacteria. An increased proportion of Fusobacteria and Firmicutes is beneficial to intestinal health [ 71 ]. Proteobacteria are Gram-negative bacteria, and the outer membrane is mainly composed of lipopolysaccharides.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Andrographolide Levels on Growth Performance, Antioxidant Capacity, Intestinal Immune Function and Microbioma of Rice Field Eel (Monopterus Albus)

Shi

Zhong

et al. 2020

Animals

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An eight-week feeding trial was conducted to investigate the effects of dietary andrographolide on the growth performance, antioxidant capacity in the liver, intestinal inflammatory response and microbiota of Monopterus albus. A total of 900 health fish (25.00 ± 0.15 g) were randomly divided into five groups: AD1 (the basal diet) as the control, and AD2, AD3, AD4 and AD5 groups, which were fed the basal diet supplemented with 75, 150, 225 and 300 mg/kg andrographolide, respectively. The results showed that compared with the control group, dietary andrographolide supplementation (1) significantly increased trypsin and lipase activities in the intestine, and increased the weight gain rate but not significantly; (2) significantly increased the levels of glutathione reductase (GR), glutathione (GSH) and glutathione peroxidase (GPx) and the content of in the liver; significantly decreased the contents of reactive oxygen species (ROS) and malondialdehyde (MDA); remarkably upregulated the Nrf2, SOD1, GSTK and GSTO mRNA levels in the liver; downregulated the Keap1 mRNA level; (3) significantly increased the villi length and goblet cell numbers in the intestine, remarkably upregulated the Occludin mRNA level in the intestine, downregulated the Claudin-15 mRNA level; (4) remarkably upregulated the IL-10, TGF-β1 and TGF-β3 mRNA levels in the intestine; downregulated the IL-12β and TLR-3 mRNA levels; (5) significantly decreased the richness and diversity of the intestinal microbioma, increased the percentages of Fusobacteria and Firmicutes and significantly decreased the percentages of Cyanobacteria and Proteobacteria. In conclusion, these results showed that dietary low-dose andrographolide (75 and 150 mg/kg) promoted growth and antioxidant capacity, regulated the intestinal microbioma, enhanced intestinal physical and immune barrier function in rice field eel.

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Section: Discussionmentioning

confidence: 99%

Effects of Dietary Andrographolide Levels on Growth Performance, Antioxidant Capacity, Intestinal Immune Function and Microbioma of Rice Field Eel (Monopterus Albus)

Shi

Zhong

et al. 2020

Animals

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“…Phycicoccus and Collinsella also showed significantly-higher abundance in tilapia fed β-glucan. These two groups of microorganisms showed higher abundance in the intestine of Eriocheir sinensis and canines when fed diets with L-tryptophan and green tea polyphenols, respectively [69,70]. Compared to tilapia in brackish water fed a basal diet, 0.4% β-glucan in the diet significantly increased the richness of Streptomyces in the intestine.…”

Section: Discussionmentioning

confidence: 93%

Recovery from Hypersaline-Stress-Induced Immunity Damage and Intestinal-Microbiota Changes through Dietary β-glucan Supplementation in Nile tilapia (Oreochromis niloticus)

Suo

Wang

et al. 2020

Animals

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Long-term exposure to hyperosmotic environments can induce severe immune damage and increase risk in tilapia breeding. As an effective immunoregulator, β-glucan has attracted extensive attention in nutritional research and given rise to high expectations of improving health status and alleviating organismal damage in tilapia, Oreochromis niloticus, in brackish water. In this study, an 8-week cultivation experiment was conducted on tilapia fed a basal diet or diets with β-glucan supplementation in freshwater (control) and brackish water. Growth performance, hematological aspects, immune cytokine expression, and the intestinal microbiota of tilapia were analyzed. The results indicated that supplementation with β-glucan significantly reduced the enlarged spleen of tilapia resulting from hypersaline stress. Tilapia fed β-glucan showed significantly-greater decreases in the red blood cell count, hematocrit, red cell distribution width, platelet count, and plateletcrit than those fed the basal diet. β-glucan significantly decreased the high expression of immune-related genes in the spleen induced by hyperosmotic stress. In the intestine, the high migration inhibitory factor-2 (MIF-2) and IL-1β gene expression induced by hypersaline stress was significantly reduced. β-glucan supplementation also significantly increased the abundance of beneficial microbiota such as Lactobacillus, Phycicoccus, and Rikenellaceae. Therefore, dietary β-glucan supplementation can significantly reduce spleen enlargement and improve immune function in tilapia in brackish water. β-glucan intake can also optimize the intestinal microbiota of tilapia in brackish water and improve fish health.

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“…(101). Similarly, Trp supplementation can enhance the immunity and antioxidant capacity of crustaceans, as well as increase intestinal microbiota (29,30), which suggest that intestinal microbiota regulate the immune system of crustaceans via Trp metabolites. Trp metabolism may therefore reveal the relationship between crustaceans and microorganisms.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 97%

“…Nonetheless, Trp and its metabolites are reported to play several physiological and immune-related functions in marine animals. In crustaceans, dietary Trp supplementation improves the growth index and survival rate ( 29 , 109 ). It has also been shown that Trp (metabolites) decreases the aggressive behavior (fights/attacks) of juvenile S. serrata ( 15 , 110 ), improves reproduction in P. monodon ( 111 ) and freshwater crab ( Barytelphusa guerini ) ( 109 ), as well as embryonic development of the giant freshwater prawn Macrobrachium rosenbergii ( 112 ).…”

Section: Amino Acid Metabolism and Crustacean Immunitymentioning

confidence: 99%

“…It has also been shown that Trp (metabolites) decreases the aggressive behavior (fights/attacks) of juvenile S. serrata ( 15 , 110 ), improves reproduction in P. monodon ( 111 ) and freshwater crab ( Barytelphusa guerini ) ( 109 ), as well as embryonic development of the giant freshwater prawn Macrobrachium rosenbergii ( 112 ). In terms of immunity, Trp supplementation increases intestinal microbiota of E. sinensis , resulting in higher survival rates upon bacterial challenge ( 29 ). While loss of limbs in crabs decreases their immunity and survival rate ( 113 , 114 ), dietary Trp supplementation improves their immune indices [e.g., the total hemocyte count (THC), phagocytosis rate, acid phosphatase (ACP), and alkaline phosphatase (ALP) activity, etc.]…”

Section: Amino Acid Metabolism and Crustacean Immunitymentioning

confidence: 99%

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Modulation of Crustacean Innate Immune Response by Amino Acids and Their Metabolites: Inferences From Other Species

et al. 2020

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Aquaculture production of crustaceans (mainly shrimp and crabs) has expanded globally, but disease outbreaks and pathogenic infections have hampered production in the last two decades. As invertebrates, crustaceans lack an adaptive immune system and mainly defend and protect themselves using their innate immune system. The immune system derives energy and metabolites from nutrients, with amino acids constituting one such source. A growing number of studies have shown that amino acids and their metabolites are involved in the activation, synthesis, proliferation, and differentiation of immune cells, as well as in the activation of immune related signaling pathways, reduction of inflammatory response and regulation of oxidative stress. Key enzymes in amino acid metabolism have also been implicated in the regulation of the immune system. Here, we reviewed the role played by amino acids and their metabolites in immune-modulation in crustaceans. Information is inferred from mammals and fish where none exists for crustaceans. Research themes are identified and the relevant research gaps highlighted for further studies.

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Effect of dietary L-tryptophan on the survival, immune response and gut microbiota of the Chinese mitten crab, Eriocheir sinensis

Cited by 37 publications

References 54 publications

Effects of Dietary Andrographolide Levels on Growth Performance, Antioxidant Capacity, Intestinal Immune Function and Microbioma of Rice Field Eel (Monopterus Albus)

Effects of Dietary Andrographolide Levels on Growth Performance, Antioxidant Capacity, Intestinal Immune Function and Microbioma of Rice Field Eel (Monopterus Albus)

Recovery from Hypersaline-Stress-Induced Immunity Damage and Intestinal-Microbiota Changes through Dietary β-glucan Supplementation in Nile tilapia (Oreochromis niloticus)

Modulation of Crustacean Innate Immune Response by Amino Acids and Their Metabolites: Inferences From Other Species

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