Effect of Dietary Avocado Oils on Hepatic Collagen Metabolism

Abstract

The effect of various avocado and soybean oils on collagen metabolism in the liver was studied in growing female rats for 8 weeks and in day-old chicks for 1 week. In comparison with rats fed either refined avocado oil, refined or unrefined soybean oils, rats fed unrefined avocado oil showed a significant decrease in total collagen solubility in the liver, while there were no changes in total collagen, protein and moisture content. Chicks fed unrefined avocado oil as compared to those fed refined avocado oil also showed a decrease in hepatic total soluble collagen while hepatic total collagen remained unaffected. Electron micrographs and light-microscope examinations of rats’ liver revealed collagen accumulation in the periportal location. This is suggestive of the early stages of fibrosis.

Avocado Oil: Characteristics, Properties, and Applications

“…Some authors [68,69,70] studied the relationship between avocado oil and collagen metabolism in both the skin and liver, finding that oil obtained from intact fruit (pulp and seed), refined with hexane, was associated with fibrosis in the liver, an increase in liver enzymes and consequently hepatotoxicity.…”

Avocado Oil: Characteristics, Properties, and Applications

“…Some authors [68,69,70] studied the relationship between avocado oil and collagen metabolism in both the skin and liver, finding that oil obtained from intact fruit (pulp and seed), refined with hexane, was associated with fibrosis in the liver, an increase in liver enzymes and consequently hepatotoxicity.…”

Avocado Oil: Characteristics, Properties, and Applications

“…Some authors [68,69,70] studied the relationship between avocado oil and collagen metabolism in both the skin and liver, finding that oil obtained from intact fruit (pulp and seed), refined with hexane, was associated with fibrosis in the liver, an increase in liver enzymes and consequently hepatotoxicity.…”

Avocado Oil: Characteristics, Properties, and Applications

“…Some authors [68,69,70] studied the relationship between avocado oil and collagen metabolism in both the skin and liver, finding that oil obtained from intact fruit (pulp and seed), refined with hexane, was associated with fibrosis in the liver, an increase in liver enzymes and consequently hepatotoxicity.…”