Effect of diagnosis on survival benefit of lung transplantation for end-stage lung disease

Hosenpud, Jeffrey D.; Bennett, Leah E.; Keck, Berkley M; Edwards, Erik; Novick, Richard J.

doi:10.1016/s0140-6736(97)06405-2

Cited by 453 publications

(248 citation statements)

References 15 publications

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“…Despite the progress since the early 1980s, the short-and long-term outcomes of lung recipients are not as good as those for other solid organs [75]. Pulmonary function improves, but exercise capacity may still be limited due to peripheral muscle dysfunction [76,77]. PR further improves exercise and QoL after lung transplantation [78].…”

Section: Lung Transplantationmentioning

confidence: 99%

Nonpharmacological treatment and relief of symptoms in COPD

Clini

Ambrosino²

2008

European Respiratory Journal

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Evidence-based guidelines for chronic obstructive pulmonary disease (COPD) have recently been developed.Nonpharmacological treatments have evolved rapidly as an essential part of COPD therapy. They are especially important as complementary interventions in severe or very severe disease, when there is loss in function, a reduction in quality of life and when psychological impairments further complicate the disease.The present article discusses the most used nonpharmacological treatments for severe COPD patients (rehabilitation, long-term oxygen therapy, surgery, noninvasive positive pressure ventilation and supportive nutrition) and their evidence-based usefulness in promoting strategies that relieve symptoms.All of these interventions are used during end-stage disease, to promote self-efficacy, relieve symptoms and prevent further deterioration. These therapeutic options support physicians and allied professionals in improving symptom management for their patients.

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Section: Lung Transplantationmentioning

confidence: 99%

Nonpharmacological treatment and relief of symptoms in COPD

Clini

Ambrosino²

2008

European Respiratory Journal

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“…NETT also found that the wide use of LVRS was limited in clinical contexts because of the physical condition the patient had to be in, surgical trauma, a postoperative mortality rate of up to 7.9% in the next 90 days, an incidence of pulmonary complications as high as 29.8%, and an incidence of cardiovascular complications as high as 20.8%. Whether lung transplantation may improve lung function, pulmonary activity, quality of life, and longterm survival for patients with emphysema appears inconclusive, and such an option cannot be widely promoted due to the vast shortage of donors, surgical trauma, major problems after transplant rejection, and infection (8,9). Therefore, surgery has limited ability to meet clinical needs, and a new, minimally invasive, and effective treatment is needed to eliminate the bottleneck limiting current techniques and approaches.…”

Section: Discussionmentioning

confidence: 99%

Status of and prospects for bronchoscopic lung volume reduction for patients with severe emphysema

Wang

et al. 2016

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“…1) [16]. Risk of mortality while waiting for lung transplantation is significantly greater for patients with IPF compared with cystic fibrosis and emphysema [17]. Thus, lung transplantation has become one of the treatments of choice for patients with advanced IPF [18].…”

Section: Transplantationmentioning

confidence: 99%

Follow-up and nonpharmacological management of the idiopathic pulmonary fibrosis patient

Egan¹

2011

European Respiratory Review

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Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal form of diffuse interstitial lung disease. Management of IPF requires an orderly approach, with regular evaluations and implementation of both pharmacological and nonpharmacological treatments. Pulmonary rehabilitation can relieve patients from the distressing symptoms of IPF and improve quality of life. Oxygen therapy is central to treatment of all patients. Lung transplantation enhances survival in selected patients. Mechanical ventilation may be used in patients with acute exacerbations, but the prognosis is poor in these cases. Palliative care focuses on symptom management, advance directives and end-of-life planning. Patient support groups may also play an important role.KEYWORDS: Idiopathic pulmonary fibrosis, lung allocation score, lung transplantation, oxygen therapy, palliative care, pulmonary rehabilitation I diopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal form of diffuse interstitial lung disease which is associated with substantial mortality and morbidity [1,2]. It accounts for nearly 30% of lung transplantation procedures performed worldwide [3]. The disease is usually characterised by gradual onset of symptoms, with dyspnoea being the most prominent and the most disabling [4]. Risk factors associated with disease development include smoking, drug exposure, chronic aspiration, infectious agents and genetic predisposition [1].The management of IPF requires a methodical approach with regular evaluations and the implementation of both pharmacological and nonpharmacological treatment strategies. Potential pharmacotherapy includes corticosteroids, immunosuppressive agents and/or antifibrotic agents [1]. Thus, it is important to consider what nonpharmacological interventions are available that might allow patients with IPF to optimise their quality of life [5]. REHABILITATIONPulmonary rehabilitation has become the standard of care for chronic lung disease because of its effectiveness in alleviating symptoms, reducing the duration of hospital stays, increasing exercise tolerance and maximising functional ability [6,7]. Exercise rehabilitation has also been associated with positive psychosocial outcomes, including reduced symptoms of anxiety and depression [8].Pulmonary rehabilitation in IPF has been associated with a statistically significant improvement in 6-min walk distance and dyspnoea [9], although the role of maintenance exercise programmes following the initial structured training remains unclear [10]. Patients should be educated with regard to the treatment and prevention of infections [11]. Patients undergoing lung transplantation are required to participate in preoperative and postoperative pulmonary rehabilitation. The programmes help physicians to select appropriate surgical candidates, and also prepare patients physically and psychologically for the stress of surgery [10].Successful pulmonary rehabilitation may require behavioural changes on the part of the patient, including: weight loss, adopti...

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Effect of diagnosis on survival benefit of lung transplantation for end-stage lung disease

Cited by 453 publications

References 15 publications

Nonpharmacological treatment and relief of symptoms in COPD

Nonpharmacological treatment and relief of symptoms in COPD

Status of and prospects for bronchoscopic lung volume reduction for patients with severe emphysema

Follow-up and nonpharmacological management of the idiopathic pulmonary fibrosis patient

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