Effect of di-2-ethylhexyl phthalate on the activity of succinic dehydrogenase and adenosine triphosphatase of some vital organs of rat

Hepatic effects of phthalate esters.

“…The inhibition of these mitochondrial enzymes also indicates an interaction of DEHP with mitochondrial membranes. DEHP was also found to inhibit the activity of total and Mg' -stimulated adenosine triphosphatase (ATPase) activity of rat liver (9,19). Besides liver, the activity of SDH and ATPase was also inhibited in rat heart, lung, kidney (19) and gonads (20), indicating that suppression ofenergy-linked reactions may be a generalized effect of DEHP.…”

“…DEHP was also found to inhibit the activity of total and Mg' -stimulated adenosine triphosphatase (ATPase) activity of rat liver (9,19). Besides liver, the activity of SDH and ATPase was also inhibited in rat heart, lung, kidney (19) and gonads (20), indicating that suppression ofenergy-linked reactions may be a generalized effect of DEHP. In vivo effects of DEHP (9,15,19) were present 11 days after the final treatment with plasticizers.…”

Hepatic effects of phthalate esters.

“…The inhibition of these mitochondrial enzymes also indicates an interaction of DEHP with mitochondrial membranes. DEHP was also found to inhibit the activity of total and Mg' -stimulated adenosine triphosphatase (ATPase) activity of rat liver (9,19). Besides liver, the activity of SDH and ATPase was also inhibited in rat heart, lung, kidney (19) and gonads (20), indicating that suppression ofenergy-linked reactions may be a generalized effect of DEHP.…”

“…DEHP was also found to inhibit the activity of total and Mg' -stimulated adenosine triphosphatase (ATPase) activity of rat liver (9,19). Besides liver, the activity of SDH and ATPase was also inhibited in rat heart, lung, kidney (19) and gonads (20), indicating that suppression ofenergy-linked reactions may be a generalized effect of DEHP. In vivo effects of DEHP (9,15,19) were present 11 days after the final treatment with plasticizers.…”

Hepatic Effects of Phthalate Esters

“…The studies of Ohyama (16) suggest that phthalates are electron and energy transport inhibitors, while the observations of Inouye et al (10) indicate that phthalates can also cause uncoupling of oxidative phosphorylation. Besides liver, the activity of SDH and ATPase was also inhibited in rat heart, lung, kidney (19) and gonads (20), indicating that suppression of energy-linked reactions may be a generalized effect of DEHP. Sensitivity of various components of electron transport chain towards phthalates was indicated under in vivo conditions as well as by decreased activities of mitochondrial cytochrome-c oxidase, malic dehydrogenase and diaphorase in liver of DEHP-treated rats (9).…”

“…In vitro studies have shown that several PAEs can produce significant inhibition of mitochondrial respiration (16)(17)(18). DEHP was also found to inhibit the activity of total and Mg' -stimulated adenosine triphosphatase (ATPase) activity of rat liver (9,19). Phthalates were found to produce aberrations in mitochondrial function, e.g., di-n-butyl phthalate enhanced K+ efflux from isolated mitochondria, usually not produced by standard uncoupling agents (18).…”

The morphological development of di‐n‐pentyl phthalate induced testicular atrophy in the rat

“…The cytochemical study was subsequently performed to provide some indication of the functional integrity of the Sertoli cell, which showed very early morphological changes. Succinic dehydrogenase activity was chosen as a marker for mitochondria1 function in view of its previously reported susceptibility to phthalates in other organs (Srivastava, Prahlad and Agarwal, 1975;Srivastava, Agarwal and Prahlad, 1977).…”

Hepatic effects of phthalate esters.

“…The inhibition of these mitochondrial enzymes also indicates an interaction of DEHP with mitochondrial membranes. DEHP was also found to inhibit the activity of total and Mg' -stimulated adenosine triphosphatase (ATPase) activity of rat liver (9,19). Besides liver, the activity of SDH and ATPase was also inhibited in rat heart, lung, kidney (19) and gonads (20), indicating that suppression ofenergy-linked reactions may be a generalized effect of DEHP.…”

“…DEHP was also found to inhibit the activity of total and Mg' -stimulated adenosine triphosphatase (ATPase) activity of rat liver (9,19). Besides liver, the activity of SDH and ATPase was also inhibited in rat heart, lung, kidney (19) and gonads (20), indicating that suppression ofenergy-linked reactions may be a generalized effect of DEHP. In vivo effects of DEHP (9,15,19) were present 11 days after the final treatment with plasticizers.…”

Hepatic Effects of Phthalate Esters

“…The studies of Ohyama (16) suggest that phthalates are electron and energy transport inhibitors, while the observations of Inouye et al (10) indicate that phthalates can also cause uncoupling of oxidative phosphorylation. Besides liver, the activity of SDH and ATPase was also inhibited in rat heart, lung, kidney (19) and gonads (20), indicating that suppression of energy-linked reactions may be a generalized effect of DEHP. Sensitivity of various components of electron transport chain towards phthalates was indicated under in vivo conditions as well as by decreased activities of mitochondrial cytochrome-c oxidase, malic dehydrogenase and diaphorase in liver of DEHP-treated rats (9).…”

“…In vitro studies have shown that several PAEs can produce significant inhibition of mitochondrial respiration (16)(17)(18). DEHP was also found to inhibit the activity of total and Mg' -stimulated adenosine triphosphatase (ATPase) activity of rat liver (9,19). Phthalates were found to produce aberrations in mitochondrial function, e.g., di-n-butyl phthalate enhanced K+ efflux from isolated mitochondria, usually not produced by standard uncoupling agents (18).…”

The morphological development of di‐n‐pentyl phthalate induced testicular atrophy in the rat

“…The cytochemical study was subsequently performed to provide some indication of the functional integrity of the Sertoli cell, which showed very early morphological changes. Succinic dehydrogenase activity was chosen as a marker for mitochondria1 function in view of its previously reported susceptibility to phthalates in other organs (Srivastava, Prahlad and Agarwal, 1975;Srivastava, Agarwal and Prahlad, 1977).…”

Hepatic effects of phthalate esters.

“…The inhibition of these mitochondrial enzymes also indicates an interaction of DEHP with mitochondrial membranes. DEHP was also found to inhibit the activity of total and Mg' -stimulated adenosine triphosphatase (ATPase) activity of rat liver (9,19). Besides liver, the activity of SDH and ATPase was also inhibited in rat heart, lung, kidney (19) and gonads (20), indicating that suppression ofenergy-linked reactions may be a generalized effect of DEHP.…”

“…DEHP was also found to inhibit the activity of total and Mg' -stimulated adenosine triphosphatase (ATPase) activity of rat liver (9,19). Besides liver, the activity of SDH and ATPase was also inhibited in rat heart, lung, kidney (19) and gonads (20), indicating that suppression ofenergy-linked reactions may be a generalized effect of DEHP. In vivo effects of DEHP (9,15,19) were present 11 days after the final treatment with plasticizers.…”

Hepatic Effects of Phthalate Esters

“…The studies of Ohyama (16) suggest that phthalates are electron and energy transport inhibitors, while the observations of Inouye et al (10) indicate that phthalates can also cause uncoupling of oxidative phosphorylation. Besides liver, the activity of SDH and ATPase was also inhibited in rat heart, lung, kidney (19) and gonads (20), indicating that suppression of energy-linked reactions may be a generalized effect of DEHP. Sensitivity of various components of electron transport chain towards phthalates was indicated under in vivo conditions as well as by decreased activities of mitochondrial cytochrome-c oxidase, malic dehydrogenase and diaphorase in liver of DEHP-treated rats (9).…”

“…In vitro studies have shown that several PAEs can produce significant inhibition of mitochondrial respiration (16)(17)(18). DEHP was also found to inhibit the activity of total and Mg' -stimulated adenosine triphosphatase (ATPase) activity of rat liver (9,19). Phthalates were found to produce aberrations in mitochondrial function, e.g., di-n-butyl phthalate enhanced K+ efflux from isolated mitochondria, usually not produced by standard uncoupling agents (18).…”

The morphological development of di‐n‐pentyl phthalate induced testicular atrophy in the rat

“…The cytochemical study was subsequently performed to provide some indication of the functional integrity of the Sertoli cell, which showed very early morphological changes. Succinic dehydrogenase activity was chosen as a marker for mitochondria1 function in view of its previously reported susceptibility to phthalates in other organs (Srivastava, Prahlad and Agarwal, 1975;Srivastava, Agarwal and Prahlad, 1977).…”