Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease

Léguillette, Renaud; Tohver, T.; Bond, Stephanie L.; Nicol, J.; McDonald, Katherine

doi:10.1111/jvim.14740

Cited by 24 publications

(30 citation statements)

References 37 publications

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“…Horses with mild asthma have empirically been treated with glucocorticoids. Dexamethasone (0.05 mg/kg IM q24h) and inhaled fluticasone (3000 μg q12h) are effective at reducing hypersensitivity and hyperreactivity in horses with mild asthma . However, no improvement in bronchoalveolar lavage (BAL) neutrophil percentage was observed after short‐term administration of glucocorticoids, which is consistent with findings in severe asthma studies where the air quality was not improved .…”

Section: Introductionsupporting

confidence: 80%

Efficacy of dexamethasone, salbutamol, and reduced respirable particulate concentration on aerobic capacity in horses with smoke‐induced mild asthma

Bond

Greco‐Otto

MacLeod

et al. 2020

Veterinary Internal Medicne

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Background Mild asthma in horses decreases racing performance and impairs gas exchange. The efficacy of treatment on performance is unknown. Hypothesis Treatment targeting lung inflammation improves V˙O2peak in horses with mild asthma. Animals Thoroughbred polo horses (n = 12) with smoke‐induced mild asthma. Horses were exposed to increased ambient particulate matter (35.51 μg/m3 [PM2.5]; day mean, centrally measured) from day −33 to 0, from bushfire smoke (natural model). Methods Prospective, randomized, placebo‐controlled, double‐blinded clinical trial. All horses completed 3 V˙O2peak tests, measuring aerobic and anaerobic variables: day 0 ‐baseline; day 16 ‐after dexamethasone (20 mg IM q24h; DEX, n = 6) or saline treatment (SALINE, n = 6), under improved ambient PM2.5 concentrations (7.04 μg/m3); day 17‐15‐30mins after inhaled salbutamol (1500 μg). Bronchoalveolar lavage and mucus scoring were performed on day −8 and day 20. Linear mixed effects models were used to examine the effects of timepoint and treatment group on BAL differential cell counts, mucus scores, aerobic and anaerobic variables. Results Horses’ mucus scores improved significantly from day −8 to 20 by 1.27 ± .38 (P = .01). There was a significant increase in V˙O2peak of 15.5 ± 4.0 mL(min.kg)−1 from day 0 to 17 (P = .002), representing an average (mean) increase in V˙O2peak of 13.2%. There was no difference in V˙O2peak between treatment groups (SALINE versus DEX) at any timepoint. Conclusions and Clinical Importance This study highlighted the key role of improved air quality on functionally important airway inflammation. Evidence provided is central to increasing owner compliance regarding improved air quality for the treatment and prevention of mild asthma.

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Section: Introductionsupporting

confidence: 80%

Efficacy of dexamethasone, salbutamol, and reduced respirable particulate concentration on aerobic capacity in horses with smoke‐induced mild asthma

Bond

Greco‐Otto

MacLeod

et al. 2020

Veterinary Internal Medicne

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“…In IAD, mixed/neutrophilic and eosinophilic inflammation may be present . Similar to human asthma, RAO and IAD respond to beta‐adrenergic agonists in combination with inhaled or systemic corticosteroids …”

Section: Asthma/obstructive Airway Disease In Other Mammalian Speciesmentioning

confidence: 99%

“…In IAD, mixed/neutrophilic and eosinophilic inflammation may be present 91. Similar to human asthma, RAO and IAD respond to beta-adrenergic agonists in combination with inhaled or systemic corticosteroids 92,93. Pathologically, RAO is associated with airway remodeling, increased airway mucus and epithelial mucous metaplasia, ASM hypertrophy, and subepithelial collagen deposition.…”

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confidence: 99%

Modeling asthma: Pitfalls, promises, and the road ahead

Rosenberg

Druey

2018

Journal of Leukocyte Biology

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Asthma is a chronic, heterogeneous, and recurring inflammatory disease of the lower airways, with exacerbations that feature airway inflammation and bronchial hyperresponsiveness. Asthma has been modeled extensively via disease induction in both wild-type and genetically manipulated laboratory mice (Mus musculus). Antigen sensitization and challenge strategies have reproduced numerous important features of airway inflammation characteristic of human asthma, notably the critical roles of type 2 T helper cell cytokines. Recent models of disease induction have advanced to include physiologic aeroallergens with prolonged respiratory challenge without systemic sensitization; others incorporate tobacco, respiratory viruses, or bacteria as exacerbants. Nonetheless, differences in lung size, structure, and physiologic responses limit the degree to which airway dynamics measured in mice can be compared to human subjects. Other rodent allergic airways models, including those featuring the guinea pig (Cavia porcellus) might be considered for lung function studies. Finally, domestic cats (Feline catus) and horses (Equus caballus) develop spontaneous obstructive airway disorders with clinical and pathologic features that parallel human asthma. Information on pathogenesis and treatment of these disorders is an important resource.

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“…1,3 Treatment of equine asthma is directed at decreasing inflammation of the lungs. 4 Dexamethasone can quickly and effectively improve lung function and, ultimately, clinical signs. 1 Corticosteroids are potent anti-inflammatory drugs that effectively reduce airway hypersensitivity and inflammation in horses with equine asthma.…”

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confidence: 99%

Pilot study to quantify the time to clear dexamethasone from plasma and urine of adult horses following a single nebulisation

et al. 2019

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Objective To quantify the time to clear dexamethasone from plasma and urine of horses following a single nebulisation.Design Experimental using six Standardbred mares.Methods Dexamethasone sodium phosphate (0.04 mg/kg) diluted in 0.9% sodium chloride was administered as an aerosol using a Flexineb E2® nebuliser. Blood samples (0, 2, 4, 6, 8, 10, 12, 24, 32, 48, 72 and 96 h) and urine samples (0, 1, 4, 8, 24, 32, 48, 72 and 96 h) were collected for analysis using liquid chromatography mass spectrometry.Results Maximum plasma concentrations (t max ) were reached by the earliest detection point (2 h) after nebulisation (0.6--1.8 ng/mL), but was no longer detectable at 48 h. However, in one horse 0.1 ng/mL was found at 96 h after three consecutive readings of 0 ng/mL. The t max in urine was reached by the earliest collection point (1 h) after nebulisation (3.2-23.8 ng/mL), but was no longer present in urine at 72 h in five horses, while detectable levels (0.1 ng/mL) were still present at 96 h in one horse.Conclusions A single dose of 0.04 mg/kg of DSP administered as an aerosol through a FlexinebE2® mask was no longer detectable in blood at 48 h in six horses tested, but one horse returned a reading of 0.1 ng/mL at 96 h after having no detectable levels. Dexamethasone was not detectable in urine at 72 h in five horses but was detectable at a low concentration (0.1 ng/mL) at 96 h in one horse.

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Effect of Dexamethasone and Fluticasone on Airway Hyperresponsiveness in Horses With Inflammatory Airway Disease

Cited by 24 publications

References 37 publications

Efficacy of dexamethasone, salbutamol, and reduced respirable particulate concentration on aerobic capacity in horses with smoke‐induced mild asthma

Efficacy of dexamethasone, salbutamol, and reduced respirable particulate concentration on aerobic capacity in horses with smoke‐induced mild asthma

Modeling asthma: Pitfalls, promises, and the road ahead

Pilot study to quantify the time to clear dexamethasone from plasma and urine of adult horses following a single nebulisation

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