Search citation statements

Order By: Relevance
Select...
2
2
1
0
5
0
1

Year Published

1997
1997
2015
2015

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

0
5
0
1
Order By: Relevance
“…Our study indicates that side-chain oxygenated cholesterol can undergo metabolic transformations that may be of importance for cholesterol homoeostasis in the brain. also 7α-hydroxylated by microsomes from the nervous system [21] and other cell types [22][23][24], the substrate specificity of 7α-hydroxylation with regard to the side-chain structure was investigated. In the course of these studies other metabolic reactions were detected which are also described.…”
Section: Introductionmentioning
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1.2b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 7 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 130,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Our study indicates that side-chain oxygenated cholesterol can undergo metabolic transformations that may be of importance for cholesterol homoeostasis in the brain. also 7α-hydroxylated by microsomes from the nervous system [21] and other cell types [22][23][24], the substrate specificity of 7α-hydroxylation with regard to the side-chain structure was investigated. In the course of these studies other metabolic reactions were detected which are also described.…”
Section: Introductionmentioning
“…The organs or tissues potentially subject to the action of β‐AET on 11β‐HSD1‐mediated GC signaling include liver, muscle, brain, and adipose tissue (44,45,46) and may also involve other steroidogenic enzymes such as CYP7A, 11β‐HSD2, and tissue‐specific transcription factors (39,47). For example, DHEA‐mediated inhibition of 11β‐HSD1 activity has been reported in adipose tissue and involves a switch in CCAAT/enhancer‐binding protein (C/EBP) expression.…”
Section: Discussionmentioning
“…Androstene‐3β, 7β, 17β‐triol (β‐AET) appears to be a biologically relevant anti‐inflammatory (30) DHEA metabolite (31) with multifaceted properties that include GC‐opposing functions (32,33,34) and immune modulation (35,36). Oxidation of DHEA occurs at C‐7 in certain tissues, such as brain, liver, gut, lymphoid organs, joints and, importantly, adipose via the CYP7 enzymes (37,38,39). Although the human metabolic pathways do not favor formation of highly oxidized metabolites from exogenous DHEA (40), these 7‐hydroxy metabolites are collectively present in the low nmol/l concentrations in human circulation.…”
Section: Introductionmentioning
“…In any case, and given that glucocorticoids activate the 7α‐hydroxylating enzyme, 35 a decrease in circulating DHEA in HIV‐infected patients 36 should result in a dramatic decrease in 7α‐hydroxy‐DHEA production and lead to an immune process impairment. To our knowledge, AIDS‐related variations in circulating and tissular PREG levels are not available, but normal concentrations in brain and nerves (0.1 μM) 37,38 are nearly two orders of magnitude larger than in plasma.…”
Section: Discussionmentioning