Effect of Daily Consumption of Probiotic Yogurt on Oxidative Stress in Pregnant Women: A Randomized Controlled Clinical Trial

Abstract

Background: Due to the enhanced oxygen requirement of the mitochondria-rich placenta primarily during the third trimester, pregnancy is associated with elevated levels of oxidative stress. This study was designed to determine the effects of daily consumption of probiotic yogurt on oxidative stress among Iranian pregnant women. Methods: This randomized single-blind controlled clinical trial was performed among 70 pregnant women, singleton primigravida, aged 18-30 in their third trimester. Subjects were randomly assigned to two groups to consume 200 g/day of either conventional yogurt (n = 33) or probiotic yogurt (n = 37) for 9 weeks. Fasting blood samples were taken at baseline and after a 9-week intervention to measure oxidative stress parameters. Results: Consumption of probiotic yogurt resulted in increased erythrocyte glutathione reductase (GR) levels as compared to the conventional yogurt (p = 0.01). Despite the significant effect of probiotic yogurt consumption on plasma glutathione (67.9 µmol/l, p = 0.01), erythrocyte glutathione peroxidase (163 mmol/min/ml, p = 0.04) and serum 8-oxo-7,8-dihydroguanine levels (-74.3 ng/ml, p = 0.04), no significant differences were found between the two yogurts in terms of their effects on the mentioned parameters. Conclusion: Consumption of probiotic yogurt among pregnant women resulted in increased levels of erythrocyte GR as compared to the conventional yogurt, but could not affect other indices of oxidative stress.

Effect of Multispecies Probiotic Supplements on Metabolic Profiles, hs-CRP, and Oxidative Stress in Patients with Type 2 Diabetes

“…Such findings have also been reached with the consumption of L. fermentum ME-3 [52] and multispecies probiotics in rats [53]. However, in our previous study in pregnant women [54], consumption of probiotic yogurt containing two strains of L. acidophilus LA5 and B. animalis BB12 did not lead to a significant effect on GSH compared to conventional yogurt. The difference in findings might be explained by differences in the studied populations.…”

Effects of Probiotic Supplementation on Oxidative Stress Indices in Women with Rheumatoid Arthritis: A Randomized Double-Blind Clinical Trial

“…Nine weeks of using probiotic yogurt increased plasma glutathione and erythrocyte glutathione reductase (GR), but did not significantly affect other oxidative stress indices in pregnant women. The positive results obtained in this study were attributed to up-regulation of antioxidant enzymes and reduction of inflammatory cytokines (which produce oxygen radicals and increase oxidative stress) [41]. Mann-Whitney U test.…”

A randomized, double-blind, placebo-controlled, clinical trial on probiotic soy milk and soy milk: effects on epigenetics and oxidative stress in patients with type II diabetes

“…The effect of probiotics on oxidative stress has previously been evaluated in humans (Asemi et al 2012;Ejtahed et al 2011Ejtahed et al , 2012) and animal models (Yadav et al 2007;Toral et al 2014). To the best of our knowledge, this study is the first study assessing the effect of probiotics soy milk on mitochondrial DNA lesion among diabetic patients.…”

“…To the best of our knowledge, this study is the first study assessing the effect of probiotics soy milk on mitochondrial DNA lesion among diabetic patients. In a study by Asemi et al (2012), probiotic yogurt consumption for 9 weeks decreased the plasma concentration of 8-oxo-G among pregnant women. Epp Songisepp et al (2005) indicated that probiotic Lactobacillus fermentum ME-3 caused Fig.…”