Effect of Corticosteroids on Intraocular Pressure and Fluid Dynamics

Regulation of Glucocorticoid Responsiveness in Glaucomatous Trabecular Meshwork Cells by Glucocorticoid Receptor-β

“…Susceptibility of GCinduced ocular hypertension could be due to the levels of GR␤ in an individual's TM cells. Patients with POAG have shown greater ocular response to GCs (GC-induced IOP elevation) in other studies, 6,17,18 which is consistent with our current findings. In addition, the enhanced cutaneous GC vascular responsiveness shown in patients with POAG 46 may also be due to altered GR␤ expression in skin microvascular cells.…”

Regulation of Glucocorticoid Responsiveness in Glaucomatous Trabecular Meshwork Cells by Glucocorticoid Receptor-β

“…Susceptibility of GCinduced ocular hypertension could be due to the levels of GR␤ in an individual's TM cells. Patients with POAG have shown greater ocular response to GCs (GC-induced IOP elevation) in other studies, 6,17,18 which is consistent with our current findings. In addition, the enhanced cutaneous GC vascular responsiveness shown in patients with POAG 46 may also be due to altered GR␤ expression in skin microvascular cells.…”

Surgical outcomes of uveitic glaucoma

“…However, we found that most of the surgeries were associated with acute, recurrent uveitis. The increased prevalence of glaucoma in chronic uveitis reflects the accumulated detrimental effects of inflammation and probably the consequence of chronic corticosteroid therapy on an initially normal trabecular meshwork [15,16]. However the higher rate of secondary glaucoma was not accompanied by a higher rate of glaucoma surgery [13] in contrast with our study where acute-recurrent uveitis was the main cause of glaucoma surgery.…”

Effects of topical corticosteroid administration on intraocular pressure in normal and glaucomatous cats

“…This has the clear potential to significantly worsen potentially blinding ocular damage associated with glaucoma. A similar relationship between underlying primary glaucoma and a higher prevalence of steroid‐induced glaucoma has been well described in human patients, and has been documented in Beagles . To our knowledge, this study is the first to document a similar effect of topical CCS on IOP in cats with underlying, spontaneous glaucoma, in which aqueous outflow pathways demonstrate preexisting abnormalities, including a narrowed ciliary cleft and a paucity of aqueous outflow channels(M.H.…”

“…Human primary open‐angle glaucoma (POAG) patients, as well as their family members, are more likely to be CCS ‘responders’ as compared to the general population. The response in these individuals also tends to be more rapid and dramatic, and they have a higher risk of developing extreme elevations in IOP resulting in permanent glaucomatous damage . Similar results were also reported in a small study of Beagles with POAG .…”

Regulation of Glucocorticoid Responsiveness in Glaucomatous Trabecular Meshwork Cells by Glucocorticoid Receptor-β

“…Susceptibility of GCinduced ocular hypertension could be due to the levels of GR␤ in an individual's TM cells. Patients with POAG have shown greater ocular response to GCs (GC-induced IOP elevation) in other studies, 6,17,18 which is consistent with our current findings. In addition, the enhanced cutaneous GC vascular responsiveness shown in patients with POAG 46 may also be due to altered GR␤ expression in skin microvascular cells.…”

Surgical outcomes of uveitic glaucoma

“…However, we found that most of the surgeries were associated with acute, recurrent uveitis. The increased prevalence of glaucoma in chronic uveitis reflects the accumulated detrimental effects of inflammation and probably the consequence of chronic corticosteroid therapy on an initially normal trabecular meshwork [15,16]. However the higher rate of secondary glaucoma was not accompanied by a higher rate of glaucoma surgery [13] in contrast with our study where acute-recurrent uveitis was the main cause of glaucoma surgery.…”

Effects of topical corticosteroid administration on intraocular pressure in normal and glaucomatous cats

“…This has the clear potential to significantly worsen potentially blinding ocular damage associated with glaucoma. A similar relationship between underlying primary glaucoma and a higher prevalence of steroid‐induced glaucoma has been well described in human patients, and has been documented in Beagles . To our knowledge, this study is the first to document a similar effect of topical CCS on IOP in cats with underlying, spontaneous glaucoma, in which aqueous outflow pathways demonstrate preexisting abnormalities, including a narrowed ciliary cleft and a paucity of aqueous outflow channels(M.H.…”

“…Human primary open‐angle glaucoma (POAG) patients, as well as their family members, are more likely to be CCS ‘responders’ as compared to the general population. The response in these individuals also tends to be more rapid and dramatic, and they have a higher risk of developing extreme elevations in IOP resulting in permanent glaucomatous damage . Similar results were also reported in a small study of Beagles with POAG .…”

Regulation of Glucocorticoid Responsiveness in Glaucomatous Trabecular Meshwork Cells by Glucocorticoid Receptor-β

“…Susceptibility of GCinduced ocular hypertension could be due to the levels of GR␤ in an individual's TM cells. Patients with POAG have shown greater ocular response to GCs (GC-induced IOP elevation) in other studies, 6,17,18 which is consistent with our current findings. In addition, the enhanced cutaneous GC vascular responsiveness shown in patients with POAG 46 may also be due to altered GR␤ expression in skin microvascular cells.…”

Surgical outcomes of uveitic glaucoma

“…However, we found that most of the surgeries were associated with acute, recurrent uveitis. The increased prevalence of glaucoma in chronic uveitis reflects the accumulated detrimental effects of inflammation and probably the consequence of chronic corticosteroid therapy on an initially normal trabecular meshwork [15,16]. However the higher rate of secondary glaucoma was not accompanied by a higher rate of glaucoma surgery [13] in contrast with our study where acute-recurrent uveitis was the main cause of glaucoma surgery.…”

Effects of topical corticosteroid administration on intraocular pressure in normal and glaucomatous cats

“…This has the clear potential to significantly worsen potentially blinding ocular damage associated with glaucoma. A similar relationship between underlying primary glaucoma and a higher prevalence of steroid‐induced glaucoma has been well described in human patients, and has been documented in Beagles . To our knowledge, this study is the first to document a similar effect of topical CCS on IOP in cats with underlying, spontaneous glaucoma, in which aqueous outflow pathways demonstrate preexisting abnormalities, including a narrowed ciliary cleft and a paucity of aqueous outflow channels(M.H.…”

“…Human primary open‐angle glaucoma (POAG) patients, as well as their family members, are more likely to be CCS ‘responders’ as compared to the general population. The response in these individuals also tends to be more rapid and dramatic, and they have a higher risk of developing extreme elevations in IOP resulting in permanent glaucomatous damage . Similar results were also reported in a small study of Beagles with POAG .…”