volume 93, issue 0, P2-P-219 2020
DOI: 10.1254/jpssuppl.93.0_2-p-219
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Abstract: Mast cells (MCs) recognize antigens (Ag) via IgE-bound high affinity IgE receptors (FcεRI) and trigger type I allergic reactions. The MC activation by Ag is regulated by various bioactive substances such as PGE 2 and ATP. Recently, mas-related G protein-coupled receptor B2(MrgprB2) was identified as the Gi-coupled receptor for basic secretagogues, such as compound 48/80 (C48/80). Gi-coupled receptor signals are well known to up-regulate the Aginduced MC activation. In this study, we examined the effect of C48/…

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