2018
DOI: 10.1155/2018/7325483
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Abstract: Objective This study aims at investigating the effects and molecular mechanism of riboflavin-ultraviolet-A-induced cross-linking (corneal collagen cross-linking, CXL) on corneal neovascularization (CNV) in a rabbit alkali burn model. Methods A total of 60 rabbits were injured with alkali burns to induce CNV in the right eye and were randomly divided into six groups: Group A—injury and no treatment; Groups B, C, and D—CXL treatment for 30 min, 15 min, and 45 min administered immediately after injury, respective… Show more

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Cited by 9 publications
(6 citation statements)
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“…11 Therefore, in this study, ERK inhibitors were used to investigate the effects and the mechanism of CNV in mice. There are a large number of clinical studies, which show 12,13 that the use of different drug interventions can effectively inhibit the growth of CNV, which is consistent with the research in this article. In this study, the area of CNV was detected in three groups of mice.…”
Section: Discussionsupporting
confidence: 88%
“…11 Therefore, in this study, ERK inhibitors were used to investigate the effects and the mechanism of CNV in mice. There are a large number of clinical studies, which show 12,13 that the use of different drug interventions can effectively inhibit the growth of CNV, which is consistent with the research in this article. In this study, the area of CNV was detected in three groups of mice.…”
Section: Discussionsupporting
confidence: 88%
“…In this study, in the two described cases with confirmed herpetic inflammation, corneal ulceration healed after the cross-linking procedure. This suggests that the procedure probably had a reducing effect on neurotrophic corneal melting occurring after herpetic inflammation [ 13 ].…”
Section: Discussionmentioning
confidence: 99%
“…Da mesma forma, radiação UV-A causa a degeneração da matriz extracelular na derme, principalmente devido à interrupção da homeostase do colágeno, resultando no fotoenvelhecimento cutâneo (SHIM et al, 2012). (McCALL et al, 2010;XU et al, 2018). Todavia, o presente estudo mostra pela primeira vez, que a riboflavina, mesmo não fotossensibilizada pelo UV-A, ou seja, sem a produção de oxigênio singlet associada, foi capaz de promover a recuperação e o remodelamento dos depósitos de colágeno em animais que sofreram radiação UV-A quando ministrada por via oral, sem que haja danos adicionais relacionados ao estresse oxidativo.…”
Section: Discussionunclassified
“…Devido a esses efeitos, o VEGF pode ser considerado como o principal como fator pró-angiogênico envolvido no reparo tecidual (BARRIENTOS et al, 2008). Fonte: SHI e SUN (2018). associado ao dano nitrosativo é um evento importante na formação de lesões cutâneas até 24 horas após a radiação UV, principalmente quando se trata de radiação UV-B, e que tal agressão pode ser suprimida pelo uso de agentes antioxidantes, fármacos que possam atuar na via do estresse nitrosativo também devem ser investigados (CARRARA et al, 2019;TERRA et al, 2012a;TERRA et al, 2012b).…”
Section: Introductionunclassified
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