Effect of COL5A1, GDF5, and PPARA Genes on a Movement Screen and Neuromuscular Performance in Adolescent Team Sport Athletes

Šťastný, Petr; Lehnert, Michal; Croix, Mark De Ste; Petr, Michal; Svoboda, Zdeněk; Maixnerová, Eliška; Vařeková, Renata; Botek, Michal; Petřek, Martin; Kocourková, Lenka

doi:10.1519/jsc.0000000000003142

Cited by 16 publications

(16 citation statements)

References 57 publications

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“…No significant associations were found for either of the following polymorphisms in the present study when corrected for gender: PPARA rs4253778, IL6 rs1474347, and PPARG rs1801282. For muscle function and jumping capacity, this is well in line with previous findings in other sports, at least for the PPARA rs4253778 polymorphism (Stastny et al, 2019). However, Stastny et al (2019) found significant associations to other muscle parameters, such as reactive muscle index.…”

Section: Effect Of Selected Genessupporting

confidence: 91%

No Change – No Gain; The Effect of Age, Sex, Selected Genes and Training on Physiological and Performance Adaptations in Cross-Country Skiing

et al. 2020

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The aim was to investigate the effect of training, sex, age and selected genes on physiological and performance variables and adaptations before, and during 6 months of training in well-trained crosscountry skiers. National-level crosscountry skiers were recruited for a 6 months observational study (pre-post 1-post 2 test). All participants were tested in an outside double poling time trial (TT DP), maximal oxygen uptake in running (RUN-VO 2max), peak oxygen uptake in double poling (DP-VO 2peak), lactate threshold (LT) and oxygen cost of double poling (C DP), jump height and maximal strength (1RM) in half squat and pull-down. Blood samples were drawn to genetically screen the participants for the ACTN3 R577X, ACE I/D, PPARGC1A rs8192678, PPARG rs1801282, PPARA rs4253778, ACSL1 rs6552828, and IL6 rs1474347 polymorphisms. The skiers were instructed to train according to their own training programs and report all training in training diaries based on heart rate measures from May to October. 29 skiers completed all testing and registered their training sufficiently throughout the study period. At pre-test, significant sex and age differences were observed in TT DP (p < 0.01), DP-VO 2peak (p < 0.01), C DP (p < 0.05), MAS (p < 0.01), LT v (p < 0.01), 1RM half squat (p < 0.01), and 1RM pull-down (p < 0.01). For sex, there was also a significant difference in RUN-VO 2max (p < 0.01). No major differences were detected in physiological or performance variables based on genotypes. Total training volume ranged from 357.5 to 1056.8 min per week between participants, with a training intensity distribution of 90-5-5% in low-, moderate-and high-intensity training, respectively. Total training volume and ski-specific training increased significantly (p < 0.05) throughout the study period for the whole group, while the training intensity distribution was maintained. No physiological or performance variables improved during the 6 months of training for the whole group. No differences were observed in training progression or training adaptation between sexes

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Section: Effect Of Selected Genessupporting

confidence: 91%

No Change – No Gain; The Effect of Age, Sex, Selected Genes and Training on Physiological and Performance Adaptations in Cross-Country Skiing

et al. 2020

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“…Especially, PPARA I7 rs4253778 CC genotype was rare ( n = 6) and might cause statistical bias. On the other hand, this rs4253778 CC genotype has been rare in previous studies on the Caucasian population, where it was shown to influence physical condition level [58,59]. The second question is whether the analyzed PPARA polymorphisms are true causative factors or perhaps only in linkage disequilibrium with variants directly engaged in developing a specific trait.…”

Section: Discussionmentioning

confidence: 96%

The Polymorphisms of the Peroxisome-Proliferator Activated Receptors’ Alfa Gene Modify the Aerobic Training Induced Changes of Cholesterol and Glucose

Maciejewska-Skrendo

Buryta

Czarny

et al. 2019

JCM

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Background: PPARα is a transcriptional factor that controls the expression of genes involved in fatty acid metabolism, including fatty acid transport, uptake by the cells, intracellular binding, and activation, as well as catabolism (particularly mitochondrial fatty acid oxidation) or storage. PPARA gene polymorphisms may be crucial for maintaining lipid homeostasis and in this way, being responsible for developing specific training-induced physiological reactions. Therefore, we have decided to check if post-training changes of body mass measurements as well as chosen biochemical parameters are modulation by the PPARA genotypes. Methods: We have examined the genotype and alleles’ frequencies (described in PPARA rs1800206 and rs4253778 polymorphic sites) in 168 female participants engaged in a 12-week training program. Body composition and biochemical parameters were measured before and after the completion of a whole training program. Results: Statistical analyses revealed that PPARA intron 7 rs4253778 CC genotype modulate training response by increasing low-density lipoproteins (LDL) and glucose concentration, while PPARA Leu162Val rs1800206 CG genotype polymorphism interacts in a decrease in high-density lipoproteins (HDL) concentration. Conclusions: Carriers of PPARA intron 7 rs4253778 CC genotype and Leu162Val rs1800206 CG genotype might have potential negative training-induced cholesterol and glucose changes after aerobic exercise.

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“…One might argue that trained compared to non-trained youth possess a higher amount of long-lasting, continuous and intense training experience [27]. Another reason might be the genetic profile of trained individuals [28,29]. For example, Murtagh et al [28] investigated the relationship of multiple single nucleotide polymorphisms with physical performance measures in elite male youth soccer players and control participants.…”

Section: Discussionmentioning

confidence: 99%

Discriminative validity of the lower and upper quarter Y balance test performance: a comparison between healthy trained and untrained youth

Schwiertz

Beurskens

Muehlbauer

2020

BMC Sports Sci Med Rehabil

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Background The Lower (YBT-LQ) and Upper (YBT-UQ) Quarter Y Balance Test have been widely used for the assessment of dynamic balance and shoulder mobility/stability, respectively. However, investigations on the validity of the two tests in youth are lacking. Therefore, we performed two studies to determine discriminative validity of the YBT-LQ (study 1) and the YBT-UQ (study 2) in healthy youth. Methods Sixty-nine male soccer players (age: 14.4 ± 1.9 yrs) and 69 age-matched untrained male subjects (14.3 ± 1.6 yrs) participated in study 1 and 37 young swimmers (age: 12.3 ± 2.1 yrs) as well as 37 age−/sex-matched individuals (age: 12.5 ± 2.0 yrs) took part in study 2. Absolute (cm) and relative (% leg/arm length) maximal reach distances per reach direction and the composite score of the YBT-LQ/UQ were used as outcome measures. One-way analysis of variance and the receiver operator characteristic curve analysis (i.e., calculating the area under the curve [AUC]) were conducted to assess discriminative validity. Results Concerning the relative values, youth athletes showed significantly better YBT-LQ (study 1: p < 0.001, d = 0.86–1.21) and YBT-UQ (study 2: p < 0.001, d = 0.88–1.48) test performances compared to age- and sex-matched untrained subjects. Further, AUC-values indicated a chance of ≥74% (YBT-LQ) and ≥ 71% (YBT-UQ) to discriminate between youth athletes and controls. These findings were confirmed when using the absolute data for analysis. Conclusions According to our results, the YBT-LQ and the YBT-UQ seem to be useful test instruments to discriminate trained and untrained healthy youth performance for dynamic balance and shoulder mobility/stability, respectively.

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Effect of COL5A1, GDF5, and PPARA Genes on a Movement Screen and Neuromuscular Performance in Adolescent Team Sport Athletes

Abstract: and Pawel, Ci szczyk (2019) The effect of COL5A1, GDF5 and PPARA genes ę on a movement screen and neuromuscular performance in adolescent team sport athletes.

Cited by 16 publications

References 57 publications

No Change – No Gain; The Effect of Age, Sex, Selected Genes and Training on Physiological and Performance Adaptations in Cross-Country Skiing

No Change – No Gain; The Effect of Age, Sex, Selected Genes and Training on Physiological and Performance Adaptations in Cross-Country Skiing

The Polymorphisms of the Peroxisome-Proliferator Activated Receptors’ Alfa Gene Modify the Aerobic Training Induced Changes of Cholesterol and Glucose

Discriminative validity of the lower and upper quarter Y balance test performance: a comparison between healthy trained and untrained youth

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