Effect of Coffee on Lipopolysaccharide-Induced Immortalized Human Oral Keratinocytes

Song, Jianan; Kim, Byung-Gook; Kim, Ok-Su; Yang, Ying; Liu, Danyang; Fu, Wang; Ma, Guowu; Kim, Young; Kim, Okjoon

doi:10.3390/foods11152199

Cited by 6 publications

(4 citation statements)

References 57 publications

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“…The studies con rmed that caffeine and chlorogenic acid promoted AMPK phosphorylation and downregulated the NF-κB pathway to produce marked anti-in ammatory effects. In addition, this study supported that caffeine and chlorogenic acid play a synergistic role in periodontitis [42]. These results support our ndings.…”

Section: Discussionsupporting

confidence: 92%

“…Coffee consumption decreased biomarker concentrations of crucial metabolic and in ammatory pathway components in typical chronic diseases [38]. The extract activates the AMPK and Nrf2 pathways, which play essential roles in metabolic regulation and cytoprotection [39]. Our ndings about coffee consumption diverge from those of previous partial studies.…”

Section: Discussionmentioning

confidence: 64%

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WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

Guo

Liao

Zhou

et al. 2023

Preprint

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Objectives In this study, assessing whether coffee consumption and caffeine intake were associated with periodontitis infection separately was set as the objective. Materials and Methods Divided into binary and continuous categories, coffee consumption was set as the exposure variable along with caffeine intake and periodontitis infection as the outcome variables. Other covariables were regarded as potential confounders. The cross-sectional study was conducted based on the National Health and Nutrition Examination Survey, with multivariate regression models, subgroup analyses, smooth fitting curves, and threshold effect examinations conducted to pursue a definite correlation between exposures and the outcome. Results Negative associations were discovered between binary coffee consumption and caffeine intake and periodontitis infection, with all confounders adjusted. In subgroup analyses stratified by sex, diabetes mellitus status, and hypertension status, interaction and threshold effects were observed, which were revealed intuitively by smooth-fitting curves. Conclusions Significant negative associations between binary consumption and caffeine intake and periodontitis infection separately were indicated, with no evidence suggesting a credible correlation between continuous coffee consumption and periodontitis infection risk. The benefits of the behavior of consuming coffee and consuming caffeine were more obvious among males and individuals who do not suffer from diabetes or hypertension.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 64%

WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

Guo

Liao

Zhou

et al. 2023

Preprint

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show abstract

“…These studies confirmed that caffeine and chlorogenic acid promoted AMPK phosphorylation and downregulated the NF-κB pathway to produce a marked antiinflammatory effect. In addition, this study showed that caffeine and chlorogenic acid play a synergistic role in periodontitis [39]. These results support our findings.…”

supporting

confidence: 92%

Coffee and caffeine consumption and risk of periodontitis: National Health and Nutrition Examination Survey 2009–2014

Liao,

Zhou,

et al. 2024

Medicine Advances

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BackgroundThis study aimed to evaluate whether coffee consumption and caffeine intake are independently associated with periodontitis infection.MethodsCoffee consumption was categorized into binary and continuous variables, serving as the exposure factor alongside caffeine intake, with periodontitis infection as the outcome variable. Other covariables were regarded as potential confounders. The cross‐sectional study was conducted based on the national health and nutrition examination survey, with multivariate regression models, subgroup analyses, smooth fitting curves, and threshold effect examinations conducted to pursue a definite correlation between exposures and the outcome.ResultsNegative associations were discovered between binary coffee consumption (OR = 0.81, 95% CI = (0.71, 0.92), p‐value = 0.001) and caffeine intake (Q3: OR = 0.77, 95% CI = (0.66, 0.91), p‐value = 0.002; Q4: OR = 0.76, 95% CI = (0.64, 0.90), p‐value = 0.001) with periodontitis infection, respectively, with all confounders adjusted. In subgroup analyses stratified by gender, diabetes mellitus status, and hypertension status, interaction, and threshold effects were observed, which were intuitively revealed by smooth‐fitting curves.ConclusionsSignificant negative associations between binary consumption and caffeine intake and periodontitis infection separately were indicated, with no evidence suggesting a credible correlation between continuous coffee consumption and infection risk of periodontitis. The benefits of the behavior of consuming coffee and caffeine were more obvious among males and individuals who did not suffer from diabetes or hypertension.

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“…Therefore, we regard the differentiated effects of coffee ingredients as an explanation for the relatively weak effect size of continuous coffee consumption, and no strong association was found between whether consume coffee and the infection of periodontitis. On the contrary, Song Jianan et al found that the combination of caffeine and chlorogenic acid attenuated LPS-induced PGE2 release and enhanced the anti-oxidative effect, prompting potential modification still to be discovered [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Coffee consumption and periodontitis: a Mendelian Randomization study

Liao,

Zhou,

Lin

et al. 2023

Genes Nutr

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Background Coffee is one of the most consumed beverages in the world, coffee consumption has been growing in the United States over the past 20 years. Periodontitis is defined by the pathologic loss of the periodontal ligament and destruction of the connective tissue attachment and alveolar bone loss and is related to different systemic diseases and conditions. However, the causality has remained unclarified, thus we regarded discovering the causal relationship between coffee consumption and the liability to periodontitis as the objective of the study. Methods Coffee consumption was subdivided into binary coffee consumption and continuous coffee consumption to refine the study design. Genetic instruments were stretched from the MRC-IEU’s (MRC Integrative Epidemiology Unit) output from the GWAS pipeline using phesant-derived variables based on the UK Biobank, the Gene-Lifestyle Interactions in Dental Endpoints (GLIDE) project, and the joint meta-analysis of a recent GWAS. The IVW (Inverse Variance Weighted) was regarded as the primary method to estimate the causality, a scatter plot revealed the intuitive result, and tests for stability were also carried out. Results An effect of continuous coffee consumption on the risk of periodontitis was found, with per SD of coffee consumed increases, the risk of periodontitis rises by 1.04% (Odds Ratio of IVW is 1.0104), while the effect of binary coffee consumption on periodontitis did not meet the requirement of indicating a strong causal association, neither were the reverse causality analyses. Conclusions The study indicated the causality of continuous coffee consumption to the risk of periodontitis with a relatively small scale of effect estimate and no strong evidence for an effect of binary coffee-consuming behavior on periodontitis. There was also no intensive evidence suggesting reverse causality.

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Effect of Coffee on Lipopolysaccharide-Induced Immortalized Human Oral Keratinocytes

Cited by 6 publications

References 57 publications

WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

WITHDRAWN: Coffee and Caffeine Consumption and Risk of Periodontitis: NHANES 2009 to 2014

Coffee and caffeine consumption and risk of periodontitis: National Health and Nutrition Examination Survey 2009–2014

Coffee consumption and periodontitis: a Mendelian Randomization study

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