Effect of co-administration of intravenous lidocaine and dexmedetomidine on the recovery from laparoscopic hysterectomy: a randomized controlled trial

Xu, Siqi; Liu, Ning; Yu, Xitong; Wang, Shengbin

doi:10.23736/s0375-9393.22.16522-3

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Some clinical studies have found that drugs or supplements with different mechanisms can improve postoperative sleep quality. These drugs or supplements include the following: melatonin, which is a pineal hormone agent19; zolpidem, which is a short-acting non-benzodiazepine compound of the imidazopyridine class20; midazolam, which is a benzodiazepine21; dexmedetomidine, which is a selective alpha-2 adrenoceptor agonist22; tramadol, which is an opioid agonist23; lidocaine, which is a local anaesthetic24; and magnesium, which is a mineral and electrolyte 25. However, there are divergent conclusions regarding zolpidem, melatonin and lidocaine regarding the improvement of sleep 25–27.…”

Section: Introductionmentioning

confidence: 99%

Pharmacotherapy for improving postoperative sleep quality: a protocol for a systematic review and network meta-analysis

Yang

et al. 2023

BMJ Open

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IntroductionImproving the quality of sleep may promote enhanced recovery in surgical patients. In addition to controversial or conflicting study conclusions, the current clinical studies on pharmacotherapy for improving postoperative sleep quality are mostly limited to evaluating the effect of a specific drug or supplement compared with placebo, and they lack comparisons between drugs or supplements. Therefore, we plan to conduct a systematic review and network meta-analysis to compare the efficacy of different drugs or supplements for improving postoperative sleep quality.Methods and analysisWe will search the MEDLINE, Embase, Cochrane Central Register of Controlled Trials, CNKI and Wanfang databases from the dates of their inception to December 2022. We will only include randomised controlled trials, irrespective of language and publication status. The primary outcome is postoperative sleep quality assessed by any validated tools or polysomnography. We will assess the quality of all included trials according to version 2 of the Cochrane risk-of-bias tool for randomised trials. We will use the GeMTC package of R software to perform direct and indirect comparisons via a Bayesian framework using a random-effects model. We will use the Confidence in Network Meta-Analysis approach to evaluate the quality of evidence.Ethics and disseminationEthical approval is not required for this protocol because we will only be pooling published data. We plan to submit our review to academic conferences and peer-reviewed academic journals.PROSPERO registration numberCRD42022356508.

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Section: Introductionmentioning

confidence: 99%

Pharmacotherapy for improving postoperative sleep quality: a protocol for a systematic review and network meta-analysis

Yang

et al. 2023

BMJ Open

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“…3,4 Current evidence indicates that the use of DEX enhances postoperative recovery quality. 5,6 Esketamine, the dextral isomer of ketamine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. It has higher potency, faster recovery time, and fewer adverse effects than ketamine.…”

Section: Introductionmentioning

confidence: 99%

Effect of Dexmedetomidine and Two Different Doses of Esketamine Combined Infusion on the Quality of Recovery in Patients Undergoing Modified Radical Mastectomy for Breast Cancer - A Randomised Controlled Study

Huang,

Liu,

et al. 2023

DDDT

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This study evaluated the effect of a combined infusion of dexmedetomidine and esketamine on the quality of recovery in patients undergoing modified radical mastectomy. Methods: A total of 135 patients were randomly divided into three groups: dexmedetomidine group (group D) received dexmedetomidine (0.5 µg/kg loading, 0.4 µg/kg/h infusion), dexmedetomidine plus low-dose esketamine group (group DE 1 ) received dexmedetomidine (0.5 µg/kg loading, 0.4 µg/kg/h infusion) and esketamine (0.5 mg/kg loading, 2 µg/kg/min infusion), dexmedetomidine plus high-dose esketamine group (group DE 2 ) received dexmedetomidine (0.5 µg/kg loading, 0.4 µg/kg/h infusion) and esketamine (0.5 mg/kg loading, 4 µg/kg/min infusion). The primary outcome was the overall quality of recovery-15 (QoR-15) scores at 1 day after surgery. The secondary endpoints were total QoR-15 scores at 3 days after surgery, propofol and remifentanil requirement, awaking and extubation time, postoperative visual analogue scale (VAS) pain scores, rescue analgesic, nausea and vomiting, bradycardia, excessive sedation, nightmares, and agitation. Results: The overall QoR-15 scores were much higher in groups DE 1 and DE 2 than in groups D 1 and D 3 days after surgery (P < 0.05). VAS pain scores at 6, 12, 24 h postoperatively, propofol and remifentanil requirements were significantly lower in groups DE 1 and DE 2 than in group D (P < 0.05). Compared with group D, awaking time, extubation time, and post-anesthesia care unit (PACU) stay were significantly prolonged in groups DE 1 and DE 2 (P < 0.05) and were much longer in group DE 2 than in group DE 1 (P < 0.05). The proportion of postoperative rescue analgesics and bradycardia was higher and the incidence of excessive sedation was lower in group D than in groups DE 1 and DE 2 (P < 0.05). Conclusion: Dexmedetomidine plus esketamine partly improved postoperative recovery quality and decreased the incidence of bradycardia but prolonged awaking time, extubation time, and PACU stay, especially dexmedetomidine plus 4 µg/kg/min esketamine.

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A year in review in Minerva Anestesiologica 2023: anesthesia, analgesia, and perioperative medicine

CAVALIERE,

ALLEGRI,

APAN

et al. 2024

Minerva Anestesiol

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Effect of co-administration of intravenous lidocaine and dexmedetomidine on the recovery from laparoscopic hysterectomy: a randomized controlled trial

Cited by 4 publications

References 39 publications

Pharmacotherapy for improving postoperative sleep quality: a protocol for a systematic review and network meta-analysis

Pharmacotherapy for improving postoperative sleep quality: a protocol for a systematic review and network meta-analysis

Effect of Dexmedetomidine and Two Different Doses of Esketamine Combined Infusion on the Quality of Recovery in Patients Undergoing Modified Radical Mastectomy for Breast Cancer - A Randomised Controlled Study

A year in review in Minerva Anestesiologica 2023: anesthesia, analgesia, and perioperative medicine

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