Effect of citrocard on functional activity of cardiomyocyte mitochondria during chronic alcohol intoxication

Перфилова, В. Н.; Островский, О. В.; Веровский, В Е; Popova, T. A.; Лебедева, С. А.; Dib, H.

doi:10.1007/s10517-007-0106-y

Cited by 7 publications

(5 citation statements)

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“…These changes may be considered a sign of impairments of myocardial functioning. Data of animal experiments show a decrease in the rates of respiration and oxidative phosphorylation [78]. In baboons the cytochrome c oxidase concentration and activity decreased two-fold, while in rats causes a decrease of oxidative phosphorylation efficiency and weakening of the factor F 1 connection with mitochondrial membrane [79].…”

Section: Alcohol Effects On the Heartmentioning

confidence: 99%

“…Piceatannol possesses an additional hydroxyl group than resveratrol (3,5,4′-trihydroxystilbene) and exerts higher radical scavenging activity which was considered to contribute to the cardioprotective and antiarrhythmic effects in ischaemic-reperfused rat heart [158,159]. Another potential compound in mitochondrial therapeutics is the structural GABA analogue citrocard (phenibut citrate) that prevents the damaging effect of alcohol, which was observed from increased indexes of oxidative phosphorylation in treated animals [78]. …”

Section: Alcoholism Therapeutics At the Mitochondrial Levelmentioning

confidence: 99%

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Cellular and Mitochondrial Effects of Alcohol Consumption

Manzo‐Ávalos

Saavedra‐Molina

2010

IJERPH

214

155

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Alcohol dependence is correlated with a wide spectrum of medical, psychological, behavioral, and social problems. Acute alcohol abuse causes damage to and functional impairment of several organs affecting protein, carbohydrate, and fat metabolism. Mitochondria participate with the conversion of acetaldehyde into acetate and the generation of increased amounts of NADH. Prenatal exposure to ethanol during fetal development induces a wide spectrum of adverse effects in offspring, such as neurologic abnormalities and pre-and post-natal growth retardation. Antioxidant effects have been described due to that alcoholic beverages contain different compounds, such as polyphenols as well as resveratrol. This review analyzes diverse topics on the alcohol consumption effects in several human organs and demonstrates the direct participation of mitochondria as potential target of compounds that can be used to prevent therapies for alcohol abusers.

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Section: Alcohol Effects On the Heartmentioning

confidence: 99%

Section: Alcoholism Therapeutics At the Mitochondrial Levelmentioning

confidence: 99%

Cellular and Mitochondrial Effects of Alcohol Consumption

Manzo‐Ávalos

Saavedra‐Molina

2010

IJERPH

214

155

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“…Another potential compound in mitochondrial therapeutics is the structural GABA analog, citrocard (phenibut citrate), which prevents the damaging effect of alcohol and was observed from increased indexes of oxidative phosphorylation in treated animals [ 139 ]. Other agents that have received considerable attention as a potential therapeutic against alcohol-induced organ injury are betaine and S-adenosyl-l-methionine, which have beneficial effects on mitochondrial functions.…”

Section: Resultsmentioning

confidence: 99%

Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

2022

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Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still not fully elucidated. However, ethanol metabolism has been associated with increased oxidative stress through alcohol dehydrogenase, the microsomal ethanol oxidation system, and catalase metabolic pathways. We searched the PubMed and genome-wide association studies (GWAS) catalog databases to review the literature systematically and summarized the findings focusing on AUD and alcohol abstinence in relation to oxidative stress. In addition, we reviewed the ClinicalTrials.gov resource of the US National Library of Medicine to identify all ongoing and completed clinical trials that include therapeutic interventions based on antioxidants. The retrieved clinical and preclinical studies show that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.

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“…Например, ГАМК оказывает метаболическое действие, являясь промежуточным продуктом шунта Робертса, функционирование которого имеет большое значение в экстремальных условиях дефицита энергии [38]. Кроме того, она ограничивает процессы перикисного окисления липидов, усиливает утилизацию глюкозы и скорость окислительного фосфорилирования [5,14,59].…”

Section: пирацетам и эндотелийunclassified

Пирацетам И Бетагистин: Возможные Механизмы Эндотелиопротекции

Солгалова¹,

Солдатов²,

Першина³

et al. 2018

Курск. науч.-практ. вестн. «Человек и его здоровье»

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Бетагистин и пирацетам являются рутинными препаратами в неврологической практике, которые используются при коррекции дисциркуляторных нарушений мозгового кровообращения. Клиническая эффективность данных лекарственных средств может быть обусловлена не только нейро-, но и эндотелиотропным действием. В данном обзоре рассмотрены основные сведения о потенциальных механизмах реализации вазопротекции, включая метаболический, NO-эргический, противовоспалительный и другие компоненты действия. Бетагистин, как антагонист 3 типа и агонист 1 и 2 типа гистаминовых рецепторов, оказывает положительное влияние на церебральную и системную гемодинамику, а за счет анорексигенного действия и способности стимулировать липолиз улучшает липидный профиль. Пирацетам, наряду с ноотропным действием, способствует коррекции дисфункции митохондрий, увеличивает текучесть мембран и оказывает антиагрегантные свойства. Оба препарата подавляют синтез провоспалительных цитокинов и повышают экспрессию эндотелиальной NO-синтазы.Ключевые слова: бетагистин, пирацетам, эндотелиальная дисфункция, атеросклероз, ГАМК.

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Effect of citrocard on functional activity of cardiomyocyte mitochondria during chronic alcohol intoxication

Cited by 7 publications

References 1 publication

Cellular and Mitochondrial Effects of Alcohol Consumption

Cellular and Mitochondrial Effects of Alcohol Consumption

Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

Пирацетам И Бетагистин: Возможные Механизмы Эндотелиопротекции

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