Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A

Umehara, Hiroshi; Nishii, Yoichi; Miyamoto, Masaki; Kakehi, Yoshiyuki; Kioka, Noriyuki; Amachi, Teruo; Koizumi, Jun; Hagiwara, Masatoshi; Ueda, Kazumitsu

doi:10.1016/s0006-291x(02)03017-6

Cited by 20 publications

(20 citation statements)

References 20 publications

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“…Seventy-eight genes seemed to be differentially expressed in both variants: 15% were located in regions that had sustained losses (11). Among the 78 genes, only two, CLK1 and RAI, were previously associated with a response to cisplatin treatment (29,30). However, none were associated with resistance to temozolomide.…”

Section: Gene Expression Alterations Intemozolomide-resistant Variantmentioning

confidence: 99%

Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line

Auger

Thillet

Wanherdrick

et al. 2006

Molecular Cancer Therapeutics

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Section: Gene Expression Alterations Intemozolomide-resistant Variantmentioning

confidence: 99%

Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line

Auger

Thillet

Wanherdrick

et al. 2006

Molecular Cancer Therapeutics

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“…High levels of gene expression of SRPK1 have been detected in testicular cancer, one of the most CDDP-sensitive tumors. In fact, SRPK1 is considered as a marker of response to CDDP (62), in the sense that CDDP induces high levels of this protein that are required to phosphorylate different substrates (SR-proteins), altering their subnuclear localization and ultimately causing an inhibition of RNA splicing (53,63). Data in our study suggest, for the first time, that SRPK1 is not only involved in CDDP sensitivity but also in OXA sensitivity.…”

Section: Regulation Of Genes Involved In the Detoxification Systemmentioning

confidence: 99%

“…Finally, several studies have described that serine-rich (SR) proteins and the kinases that phosphorylate them (SRPKs) may also play a role in CDDP-resistance (52,53). SR proteins have an important role in both constitutive and alternative mRNA splicing in mammalian cells (54).…”

Section: Introductionmentioning

confidence: 99%

Expression analysis of genes involved in oxaliplatin response and development of oxaliplatin-resistant HT29 colon cancer cells

et al. 2006

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Abstract.The interrelationship between platinum resistance and clinical response is not well established. The purpose of this study is to evaluate the expression of 14 genes involved in platinum resistance in a colon cancer cell line (HT29) and its oxaliplatin (OXA)-resistant sublines. Resistant cells exhibited lower expression of many of these genes suggesting that several pathways may be implicated in OXA resistance. Particularly, OXA resistance is accompanied by defects in drug uptake (downregulation of the hCTR1 transporter) and enhanced DNA repair (upregulation of the XPD gene). Our data also confirmed that copper transporters and chaperones are involved in OXA resistance in colorectal cancer cells as evidenced by the overexpression of ATP7A and CCS in response to OXA exposure. Moreover, increased CCS expression suggests a role for SOD1 in OXA detoxification. Whereas exposure to OXA in HT29 induced significant changes in expression of many of the genes analyzed, only ATP7A, XPD and SRPK1 gene expression was increased in OXA-treated HTOXAR3 resistant cells. To our knowledge, this is the first report of implicating SRPK1 in OXA resistance. This study provides the basis for further evaluation of these putative markers of OXA response and resistance in colorectal cancer patients who are candidates for treatment with OXA.

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“…is the human homologue of yeast LUC7P (Umehara et al, 2003). CROP is a novel putative SR protein sharing the common function with LUC7L.…”

Section: Discussionmentioning

confidence: 99%

“…CROP is a novel putative SR protein sharing the common function with LUC7L. CROP/hLuc7A has been studied as a key molecule of cisplatin resistance of anticancer therapy targeting a variety of malignant tumors because it is overexpressed in cisplatin-resistant cell lines (Umehara et al, 2003). In this context, LUC7L is considered as a possible target for drug resistance in tumor in a manner similar to its mammalian counterparts.…”

Section: Discussionmentioning

confidence: 99%

Fish Myogenic Regulatory Protein LUC7L: Characterization and Expression Analysis in Korean Rose Bitterling (Rhodeus uyekii)

Kim¹,

Kong²,

Kim³

et al. 2014

Development &Amp; Reproduciton

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Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A

Cited by 20 publications

References 20 publications

Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line

Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell line

Expression analysis of genes involved in oxaliplatin response and development of oxaliplatin-resistant HT29 colon cancer cells

Fish Myogenic Regulatory Protein LUC7L: Characterization and Expression Analysis in Korean Rose Bitterling (Rhodeus uyekii)

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