Effect of chronic restraint stress on carbohydrate metabolism in rat

Zardooz, Homeira; Asl, Saleh Zahedi; Naseri, Mohammad Kazem Gharib; Hedayati, Mehdi

doi:10.1016/j.physbeh.2006.06.023

Cited by 62 publications

(55 citation statements)

References 45 publications

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“…In the recent study, all parameters of adverse male reproductive system including decreased body weight in rats exposed to restraint stress (Fig. 1a and Table 1) were similar to those parameters previously documented (Orr and Mann, 1990;Carrasco and van de Kar, 2003;Zardooz et al, 2006;Weissman et al, 2009;Hari Priya and Sreenivasula Reddy, 2012;Lin et al, 2014;Prabsattroo et al, 2015). In explanation of weight loss (Table 1), it is known that testosterone activates the protein synthetic apparatus muscles and other organs while corticosterone increases protein catabolism and decreases protein synthesis.…”

Section: Discussionsupporting

confidence: 82%

Changes of testicular phosphorylated proteins in response to restraint stress in male rats

Arun

Burawat

Sukhorum

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To investigate male reproductive parameters via changes of potential testicular protein markers in restraint-stress rats. Methods: Male Sprague-Dawley rats were divided into two groups (non-immobilized control and restraint-immobilized/stress groups, n=8 each group). The stress animals were immobilized (12 h/d) by a restraint cage for 7 consecutive days. All reproductive parameters, morphology and histology were observed and compared between groups. In addition, the expression of steroidogenic acute regulatory (StAR) and phosphotyrosine proteins (previously localized in Sertoli and late spermatid cells) in testicular lysate was assayed by immuno-Western blotting. Results: Testosterone level, sperm concentration and sperm head normality of stress rats were significantly decreased while the corticosterone level was increased as compared with the control (P<0.05). Histologically, stress rats showed low sperm mass in epididymal lumen and some atrophy of seminiferous tubules. Although the expression of testicular StAR protein was not significantly different between groups, changed patterns of the 131, 95, and 75 kDa testicular phosphorylated proteins were observed in the stress group compared with the control group. The intensity of a testicular 95-kDa phosphorylated protein was significantly decreased in stress rats. Conclusions: This study has demonstrated the alteration of testicular phosphorylated protein patterns, associated with adverse male reproductive parameters in stress rats. It could be an explanation of some infertility in stress males.

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Section: Discussionsupporting

confidence: 82%

Changes of testicular phosphorylated proteins in response to restraint stress in male rats

Arun

Burawat

Sukhorum

et al. 2016

J. Zhejiang Univ. Sci. B

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“…Our results show that CRS could lead to a decrease in body weight, which is consistent with that reported by Homerira Zardooz et al [32] . The restraint of body weight growth is an obvious phenomenon during the process of depression.…”

Section: There Is a Relationship Between Crs And Estrogensupporting

confidence: 94%

Preventive effect of estrogen on depression-like behavior induced by chronic restraint stress

2010

Neurosci. Bull.

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Objective To investigate the roles of estrogen and kalirin-7 in chronic restraint stress (CRS)-induced depression and the pathophysiological mechanism of depression. Methods Healthy female mice from Institute of Cancer Research (ICR) were randomly divided into 3 groups: control group, CRS group, and estrogen + CRS group. CRS was used to establish the animal model of depression. Forced swimming test and immunohistochemistry method were utilized to investigate the animal behavior and kalirin-7 expression in the hippocampus, respectively. Results Compared with the control group, the CRS mice displayed depression-like behaviors, including a significant reduction in body weight, a significant increase in immobility time in forced swimming test, and a dramatic decrease in kalirin-7 expression in the hippocampus. However, administration of estrogen attenuated the CRS-induced negative behaviors, and simultaneously increased kalirin-7 expression. Conclusion Estrogen replacement therapy (ERT) could prevent CRS-induced depression-like behaviors in female ICR mice. Besides, kalirin-7 also plays a role in preventing CRS-induced depression-like behaviors.

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“…Exposure to stress conditions increases the number of heterophils and decreases the numbers of lymphocytes (Siegel, 1995). In addition, heat stress stimulates the hypothalamic-pituitary-adrenal axis, with a resultant increase in secretion of corticosterone (Zardooz et al, 2006). The increase in corticosterone, along with catecholamines and glucocorticoids, induces glycogen breakdown in the liver, leading to increased glucose concentrations in the blood (Donaldson et al, 1991).…”

Section: Supplements To Combat Heat Stress In Broiler Chickensmentioning

confidence: 99%

The effects of water replacement by oral rehydration fluids with or without betaine supplementation on performance, acid-base balance, and water retention of heat-stressed broiler chickens

Sayed

Downing

2011

Poultry Science

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Exposing broilers to a high temperature increases water and electrolyte K(+) and Na(+) excretion, which negatively affects the heat dissipation capacity and acid-base homeostasis, resulting in losses in growth performance. In this experiment, the efficacy of providing oral rehydration therapy and betaine on growth performance, acid-base balance, and water and electrolyte retention was evaluated. A total of 432 one-day-old broiler chicks (Cobb) were allocated to 72 metabolic cages and reared to 31 d of age under standard conditions. From 32 to 41 d of age, chicks were exposed to heat stress (ambient temperature, 32°C) and high RH (80 to 100% RH) for 9 h daily. The ameliorative effects of a 3 × 3 factorial array of treatments administered via drinking water were evaluated in 8 replicates of 6 chicks per cage for each treatment. Two oral rehydration therapy (ORT) fluids, based on either citrate or bicarbonate salts, were added to tap water. In addition, betaine was added to tap water at an inclusion rate of 0, 500, or 1,000 mg/L to complete the array of 9 liquid-based treatments. Growth performance was assessed at 32, 35, and 41 d of age. From 32 to 35 d of age, chicks receiving ORT fluids exhibited improved growth performance, water balance, and electrolyte (K(+), Na(+)) retention. In addition, the physiological response to stress was attenuated, as indicated by lower heterophil-to-lymphocyte ratios and blood glucose concentrations relative to the negative controls. The addition of betaine at an inclusion rate of 500 mg/L improved BW gain. From d 36 to 41, treatments did not significantly influence growth performance, which suggests that chicks receiving tap water were able to compensate and adapt to the heat-stress conditions. The results demonstrate that the beneficial effects of providing ORT fluids and 500 mg of betaine/L were observed only during the first 4 d of heat exposure. After this period, adaptation to the heat appears to occur, and none of the treatments was successful in improving growth performance.

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Effect of chronic restraint stress on carbohydrate metabolism in rat

Cited by 62 publications

References 45 publications

Changes of testicular phosphorylated proteins in response to restraint stress in male rats

Changes of testicular phosphorylated proteins in response to restraint stress in male rats

Preventive effect of estrogen on depression-like behavior induced by chronic restraint stress

The effects of water replacement by oral rehydration fluids with or without betaine supplementation on performance, acid-base balance, and water retention of heat-stressed broiler chickens

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