Effect of chronic ethanol ingestion and exercise training on skeletal muscle in rat

Vila, L.; Ferrando, Ana; Voces, J.; Oliveira, C. Cabral de; Prieto, J. E.; Alvarez, Ana I.

doi:10.1016/s0376-8716(00)00223-4

Cited by 11 publications

(13 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Specifically, it has been demonstrated that alcohol consumption decreases glucose and amino acid utilization, which can have adverse effects on energy supply to exercising muscle [119-121]. Ethanol consumption induces hypoglycemia and decreases glucose appearance in plasma by decreasing hepatic gluconeogenesis [122].…”

Section: Ethanol (Alcohol)mentioning

confidence: 99%

The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance

et al. 2013

View full text Add to dashboard Cite

Caffeine, nicotine, ethanol and tetrahydrocannabinol (THC) are among the most prevalent and culturally accepted drugs in western society. For example, in Europe and North America up to 90% of the adult population drinks coffee daily and, although less prevalent, the other drugs are also used extensively by the population. Smoked tobacco, excessive alcohol consumption and marijuana (cannabis) smoking are addictive and exhibit adverse health effects. These drugs are not only common in the general population, but have also made their way into elite sports because of their purported performance-altering potential. Only one of the drugs (i.e., caffeine) has enough scientific evidence indicating an ergogenic effect. There is some preliminary evidence for nicotine as an ergogenic aid, but further study is required; cannabis and alcohol can exhibit ergogenic potential under specific circumstances but are in general believed to be ergolytic for sports performance. These drugs are currently (THC, ethanol) or have been (caffeine) on the prohibited list of the World Anti-Doping Agency or are being monitored (nicotine) due to their potential ergogenic or ergolytic effects. The aim of this brief review is to evaluate the effects of caffeine, nicotine, ethanol and THC by: 1) examining evidence supporting the ergogenic or ergolytic effects; 2) providing an overview of the mechanism(s) of action and physiological effects; and 3) where appropriate, reviewing their impact as performance-altering aids used in recreational and elite sports.

show abstract

Section: Ethanol (Alcohol)mentioning

confidence: 99%

The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance

et al. 2013

View full text Add to dashboard Cite

show abstract

“…altering the fiber area of tissues and decreasing capillary density. 27 Our findings suggested that exercise could reduce the maximum level of rapidly produced aldehyde by inhibiting ADH gene and enzyme expression. However, additional detailed studies are required to determine the specific mechanisms linking exercise and ADH gene expression, particularly with respect to the four genes found to be differentially expressed.…”

Section: Fig 1 Adh1mentioning

confidence: 95%

Effects of Exercise Intensity on Alcohol Dehydrogenase Gene Expression in the Rat Large IntestineExercise and ADH Gene Expression

Choi

2018

JOMH

View full text Add to dashboard Cite

show abstract

“…69 This contrasts with studies using exercise regimens to prevent the myopathy without primary consideration of nutritional factors. 70 …”

Section: The Contribution Of Inactivity To Alcoholic Myopathymentioning

confidence: 99%

Ca 2+ -regulatory muscle proteins in the alcohol-fed rat

et al. 2003

View full text Add to dashboard Cite

Alcoholic myopathy is characterized by muscle weakness and difficulties in gait and locomotion. It is one of the most prevalent skeletal muscle disorders in the Western hemisphere, affecting between 40% and 60% of all chronic alcohol misusers. However, the pathogenic mechanisms are unknown, although recent studies have suggested that membrane defects occur as a consequence of chronic alcohol exposure. It was our hypothesis that alcohol ingestion perturbs membranelocated proteins associated with intracellular signalling and contractility, in particular those relating to calcium homeostasis. To test this, we fed male Wistar rats nutritionally complete liquid diets containing ethanol as 35% of total dietary energy. Controls were pair-fed identical amounts of the same diet in which ethanol was replaced by isocaloric glucose. At the end of 6 weeks, rats were killed and skeletal muscles dissected. These were used to determine important ion-regulatory skeletal muscle proteins including sarcalumenin (SAR), sarcoplasmic-endoplasmic reticulum Ca 2؉ -adenosine triphosphatase (ATPase) (SERCA1), the junctional face protein of 90 kd (90-JFP), ␣ 1 -and ␣ 2 -dihydropyridine receptor (␣ 1 -DHPR and ␣ 2 -DHPR), and calsequestrin (CSQ) by immunoblotting. The relative abundance of microsomal proteins was determined by immunoblotting using the enhanced chemiluminescence (ECL) technique. The data showed that alcohol-feeding significantly reduced gastrocnemius and hind limb muscle weights (P < .05 in both instances). Concomitant changes included increases in the relative amounts of SERCA1 (P < .05) and Ca 2؉ -ATPase activity (P < .025). However, there were no statistically significant changes in either SAR, 90-JFP, ␣ 1 -DHPR or ␣ 2 -DHPR (P > .2 in all instances). Reductions in CSQ were of marginal significance (P ‫؍‬ .0950). We conclude that upregulation of SERCA1 protein and Ca 2؉ -ATPase activity may be an adaptive mechanism and/or a contributory process in the pathology of alcohol-induced muscle disease.

show abstract

Effect of chronic ethanol ingestion and exercise training on skeletal muscle in rat

Cited by 11 publications

References 28 publications

The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance

The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance

Effects of Exercise Intensity on Alcohol Dehydrogenase Gene Expression in the Rat Large IntestineExercise and ADH Gene Expression

Ca 2+ -regulatory muscle proteins in the alcohol-fed rat

Contact Info

Product

Resources

About