Effect of Chloroquine on Erythematous and Carcinogenic Response to Ultraviolet Light

Knox, John M.

doi:10.1001/archderm.1960.03730040074014

Cited by 25 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This drug was shown to screen certain wavelengths of sunlight, thereby diminishing the deleterious effect of this irradiation on light-sensitive skin. 115,116 However, it seems that CQ mediates its photoprotective effect mostly through anti-in ammatory properties. UVB can cause in ammation by inducing T-cell adhesion molecules such as ICAM-1 and cytokines like IL-1, IL-6 and TNF.…”

Section: Inhibition or Induction Of Apoptosismentioning

confidence: 99%

Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit

Woźniacka

Carter

McCauliffe

2002

Lupus

View full text Add to dashboard Cite

Antimalarials are arguably the best modality currently available for treating patients with cutaneous lupus erythematosus (LE). Although antimalarials have been used for decades in treating cutaneous LE, the precise mechanisms by which they provide therapeutic benefit are not well defined. The putative mechanisms by which antimalarials might provide therapeutic benefit to patients with cutaneous LE include a number of interrelated anti-inflammatory and immunosuppressive effects that include photoprotection, lysosomal stabilization, suppression of antigen presentation, and inhibition of prostaglandin and cytokine synthesis. If we had a more precise understanding of how antimalarials provide therapeutic benefit in cutaneous LE we might gain better insight into the pathogenic mechanisms of LE and ways of developing better therapies for afflicted patients.

show abstract

Section: Inhibition or Induction Of Apoptosismentioning

confidence: 99%

Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit

Woźniacka

Carter

McCauliffe

2002

Lupus

View full text Add to dashboard Cite

show abstract

“…Also, oral adm inistration of chloroquine to laboratory animals has inhibited other ultravioletinduced biochemical changes including non-protein-hound SH and the polarographic filtrate reaction [7]. In laboratory and clinical studies the oral adm inistration of chloroquine has decreased the incidence of skin carcinogenesis [2,3], In the present experim ent the addition of chloroquine to the diet of albino rats did not prevent liver succinic dehydrogenase from being altered by ultraviolet irradiation.…”

Section: Discussionmentioning

confidence: 41%

The Effect of Ultraviolet Exposure upon Succinic Dehydrogenase Activity

Ogura¹,

Knox²

1965

Dermatology

View full text Add to dashboard Cite

“…The topical application of CQ and mepacrine (quinacrine) decreases erythema produced by a high-pressure mercury lamp [105]. Oral administration of CQ decreases UV erythema and carcinogenesis on the ear [8,106]. Systemically administered CQ has been shown to protect animals against radiation damage and the carcinogenic effect of grenz rays [107,108].…”

Section: Uv Lightmentioning

confidence: 99%

Clinically Significant Drug Interaction Profiles of Chloroquine Analogues with Adverse Consequences and Risk Management

Al‐Bari¹,

Islam²

2015

J. Sci. Res.

View full text Add to dashboard Cite

The popularity of chloroquine (CQ) analogues, for malaria treatment in many countries emanates from it being cheap, widely available, relatively well tolerated, and having a rapid onset of action. Thus, CQ analogues are commonly sold as over-the-counter (OTC) medications. CQ analogues like hydroxychloroquine (HCQ) alone and/or other drugs in combination have been used as anti-inflammatory and immunomodulatory drugs in the treatment of various rheumatic diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), sarcoidosis, dermatomyositis, Sjögren's syndrome, chronic juvenile arthritis, psoriatic arthritis, and have shown clinical benefits with an acceptable safety profile. As anti-inflammatory mechanism, CQ inhibits pro-inflammatory cytokine release, antigen processing and blocking the actions of histamine and phospholipase A 2 . CQ analogue has also been studied for its potential as an enhancing agent in cancer therapies in various clinical trials. In many cases, the lysosomotrophic property of CQ appears to be important for the increase in efficacy and specificity to inhibit inflammatory disorders. Moreover, it is indicated that the efficacy of conventional therapies can be dramatically enhanced if CQ analogues are given in combination. Although majority of CQ analogue in combination therapies improves overall the outcome, such treatments are often associated with serious toxicities leading to fatal.

show abstract

Effect of Chloroquine on Erythematous and Carcinogenic Response to Ultraviolet Light

Cited by 25 publications

References 12 publications

Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit

Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit

The Effect of Ultraviolet Exposure upon Succinic Dehydrogenase Activity

Clinically Significant Drug Interaction Profiles of Chloroquine Analogues with Adverse Consequences and Risk Management

Contact Info

Product

Resources

About