Effect of chain length on storage stability and hydrolytic reversion of sodium polyphosphate glasses

Fuchs, Robert J.; Lutz, Charles W.

doi:10.1139/v69-509

Cited by 4 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 As pure polyphosphates, these materials are unstable to hydrolysis, 3 breaking down rapidly in basic media to smaller phosphate units, which are soluble in water. This, combined with the presence of phosphates in hydroxyapatite, have lead to several investigations into the practicalities of these materials for bone augmentation.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, degradation, and in vitro cell responses of sodium phosphate glasses for craniofacial bone repair

Gough

Christian

Scotchford

et al. 2001

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

This report outlines the initial synthesis, degradation, and short-term biocompatibility of sodium phosphate glasses, for use in the drawing of fibers and manufacture of biodegradable composites. Biocompatibility studies were performed using a macrophage cell line and primary human craniofacial osteoblasts. Sodium hydrogen phosphate and sodium dihydrogen phosphate glass synthesized for less than 1 h, resulted in a higher degradation rate than glass synthesized for 3 h or more (0.015 mg cm(-2) h(-1)). Glasses with high and low ratios of hydrogen phosphate to dihydrogen phosphate had very similar degradation rates. A condensation route for the formation of the glass should give rise to varying degradation rates with varying ratios of starting materials. It is suggested that the degradation rate of the glass is independent of the concentrations of the initial reagents and that ring-opening polymerization, which reaches an equilibrium state, occurs. Biocompatibility studies suggest minimal macrophage activation (low levels of peroxide and interleukin-1beta release and rounded morphology) and high osteoblast biocompatibility. The ultimate aim of our studies is to produce a biocompatible soluble phosphate glass that can be drawn into fibers for incorporation into a polycaprolactone matrix for craniofacial bone repair. This report demonstrates the successful production of a soluble glass, which is biocompatible with regard to osteoblasts and macrophages. Recent data from our laboratory have demonstrated successful fiber drawing and production of a novel polycaprolactone.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis, degradation, and in vitro cell responses of sodium phosphate glasses for craniofacial bone repair

Gough

Christian

Scotchford

et al. 2001

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

show abstract

“…Phosphate can be a nutrient for microbes; therefore, the presence of biofilm may increase hydrolysis. The effect of pH is less understood; some reports show that lower pH around 7 causes higher reversion rate, , whereas others showed the opposite trend. , …”

Section: Chemistry Of Orthophosphate and Polyphosphatementioning

confidence: 99%

“…15 Breaking a molecule midchain may also occur, although little evidence supports this mechanism. 16 The reversion rate increases at higher chain lengths, 17 higher temperatures, 18,19 longer water age, and lower alkalinities. 15 In addition, the presence of divalent cations and certain pipe materials, 15 biological growth, and pH may also increase reversion rates.…”

Section: ■ Introductionmentioning

confidence: 99%

Phosphate Chemical Use for Sequestration, Scale Inhibition, and Corrosion Control

Lytle

Edwards

2023

ACS EST Water

View full text Add to dashboard Cite

Water utilities commonly dose phosphates to potable water to (1) reduce aesthetic problems by sequestration, (2) inhibit calcium carbonate scale formation via threshold inhibition, and (3) reduce corrosion of lead or copper plumbing materials by forming protective pipe scales. Despite widespread use and increasing importance of phosphates, significant gaps in fundamental understanding still exist. This is partly due to the proprietary nature of some phosphate chemicals, causing experimental data and acquired knowledge for public water supplies to be considered trade secrets. Here, we summarize the current state of the science, provide operational guidance, and identify knowledge gaps regarding the use of ortho-and polyphosphates. The goal is to empower water scientists to improve phosphate chemical performance and to avoid unintended adverse consequences.

show abstract

“…Polyphosphate glasses are known to hydrolyze and break down into smaller water-soluble phosphate units. 9 Earlier work has focused on the role of calcium concentration on the degradation of polyphosphate glasses manufactured over the same time period. 10 Effects of prolonged heating during the manufacture of polyphosphate glasses suggest that the addition of calcium phosphate will result in a decrease in the degradation rate of the glass as previous research has found addition of 12 calcium units causes a change in degradation rate from approximately 0.1 g/cm 2 per hour to approximately 0.02 g/cm 2 per 100 h. 10 Osteoblast responses to such glasses have been analyzed demonstrating that the inclusion of calcium, which resulted in a significant decrease in solubility rate (as detailed above), had positive effects on proliferation and antigen expression.…”

Section: Introductionmentioning

confidence: 99%

“…Polyphosphate glasses are known to hydrolyze and break down into smaller water‐soluble phosphate units 9…”

Section: Introductionmentioning

confidence: 99%

Long‐term craniofacial osteoblast culture on a sodium phosphate and a calcium/sodium phosphate glass

Gough

Christian

Scotchford

et al. 2003

J Biomedical Materials Res

View full text Add to dashboard Cite

The aim of this study was to determine the characteristics of human craniofacial osteoblasts cultured on sodium phosphate glass and calcium-sodium phosphate glass in a long-term culture of up to 28 days. The characteristics studied were attachment, proliferation, alkaline phosphatase activity, collagen-1 production, and mineralization. A comparison of the degradation rate, measured by mass loss of the glasses, which are intended for use as a component of a novel degradable composite for craniofacial bone repair, was also performed. It was our hypothesis that the glass would be degradable with a change in degradation rate observed by calcium addition and support osteoblast proliferation and expression of the above characteristics. The inclusion of calcium into the reaction mixture significantly decreased the degradation rate, and it is suggested that the slower degradation is the result of pseudo crosslinking (ionic crosslinks rather than covalent bonding) of the polyphosphate chains by the calcium ions. Therefore, twice as many P-O bonds will need to be hydrolyzed for dissolution of the metal phosphate to occur, therefore greatly reducing the rate of hydrolysis. Osteoblasts were able to attach, spread, and proliferate in a manner comparable with the positive control, as shown by analysis of variance. Formation of a collagen-rich mineralized matrix was also observed. The results presented here suggest that a biocompatible soluble glass has been produced, which has potential to be included in a novel biodegradable craniofacial implant.

show abstract

Effect of chain length on storage stability and hydrolytic reversion of sodium polyphosphate glasses

Cited by 4 publications

References 0 publications

Synthesis, degradation, and in vitro cell responses of sodium phosphate glasses for craniofacial bone repair

Synthesis, degradation, and in vitro cell responses of sodium phosphate glasses for craniofacial bone repair

Phosphate Chemical Use for Sequestration, Scale Inhibition, and Corrosion Control

Long‐term craniofacial osteoblast culture on a sodium phosphate and a calcium/sodium phosphate glass

Contact Info

Product

Resources

About