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“…Similar pattern was observed earlier with regard to carbon tetrachloride poisoning (5). The increased serum levels were accounted for by the same authors to be due to liver damage and consequent release of the vitamin into blood.…”
Section: And Discussionsupporting
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“…Similar pattern was observed earlier with regard to carbon tetrachloride poisoning (5). The increased serum levels were accounted for by the same authors to be due to liver damage and consequent release of the vitamin into blood.…”
Section: And Discussionsupporting
“…The alternative possibility, that hepatic injury resulted in the release of tocopherol from the liver itself, appears more plausible, and is consistent with the observation that the increase in serum tocopherol was independent of bile retention or elevation of the serum cholesterol level. The recent report of Yamamoto, Okuda, and Chow (22) that the administration of carbon tetrachloride increases the release of vitamin B12 from the liver and raises its concentration in the serum lends credence to this interpretation.…”
Section: Carbon Tetrachloride-induced Acute Hepatic Injurymentioning
“…2 In other studies, these two groups of rats were purchased from a commercial source. 3 (b) Rats fed with desiccated thyroid. Young adult rats of the McCollum strain from our own colony were fed desiccated thyroid in the basal diet at the level of 0.1 to 0.2% for a period of more than three weeks.…”
Section: Methodsmentioning
“…In a study of the effect of chronic hypothyroidism on plasma vitamin B12 levels, rats from our stock colony were fed vitamin B12 free soybean diet and were given ad lib, drinking water containing 0.05% thiouracill Measurement of vitamin J5 12 in plasma and liver. Plasma and liver specimens were processed according to the procedures previously described (2,3). They were assayed for the microbiological activity of vitamin B i2 with Skeggs' medium (4) and Lactobacillus leichmannii 4797 as the test organism.…”
Section: Methodsmentioning