Effect of carbamazepine and clonazepam combination on Charles Bonnet Syndrome: a case report

Abstract

There is no established treatment for Charles Bonnet Syndrome (CBS). As a naturalistic study, a 68-year-old woman with CBS received carbamazepine alone, carbamazepine plus clonazepam, clonazepam alone, and again, carbamazepine plus clonazepam, consecutively. As a result, the combined use of carbamazepine and clonazepam was most eective. The present results suggest that carbamazepine and clonazepam combination can be useful in the treatment of CBS in some patients. #

The Present State of Charles Bonnet Syndrome

“…Since this case has been already reported by Terao,22) ~~ Charles Bonnet Syndrome only a brief description is presented.…”

Prevalence of Charles Bonnet syndrome in patients with age‐related macular degeneration: systematic review and meta‐analysis

“…; Lang et al. ; Terao ); however, no reports have mapped the efficacy of such treatments in a randomized controlled fashion. Clinical and interventional studies that targeted CBS are warranted.…”

“…rapid blinking, moving the head, leaving the environment, and social interaction, may decrease the visual hallucinations (Anderson et al 2004;Jacob et al 2004;Teunisse et al 1996). Published case reports demonstrate efficacy of antidepressants, anticonvulsants, and antipsychotics (Alamri 2018;Coletti Moja et al 2005;Lang et al 2007;Terao 1998); however, no reports have mapped the efficacy of such treatments in a randomized controlled fashion. Clinical and interventional studies that targeted CBS are warranted.…”

The elephant in the room: understanding the pathogenesis of Charles Bonnet syndrome

“…Thus far, there has been no large‐scale clinical trial for CBS medication, but a number of drugs have shown promise in reducing hallucinations in individual patients, and are good candidates for further investigation. These include several antipsychotics, the 5‐HT3 antagonist cisapride, and anti‐epileptics, including in combination . The traditional Japanese herbal preparation yi‐gan san also proved effective in an open‐label trial of 20 patients .…”

“…These include several antipsychotics, 64,65 the 5-HT3 antagonist cisapride, 66 and anti-epileptics, 67,68 including in combination. 69 The traditional Japanese herbal preparation yi-gan san also proved effective in an open-label trial of 20 patients. 70 The mechanism by which these medications may improve hallucinations in CBS remains unclear.…”