“…Future rigorously designed studies should focus on individuals who are most vulnerable to the effects of SB, including diverse groups of older adults, office workers, and those with T2D and other risk factors for cardiovascular disease, as these individuals tend to be highly sedentary and at greatest risk of poor health outcomes. 43 Standing (2 min every 20 min) -Kerr et al, 2017 43 Standing (10 min every 60 min) -Kruse et al, 2018 45 Standing (10 min every 60 min) -Yates et al, 2020 51 Standing (5 min every 30 min) -Barone Gibbs et al, 2017 34 Standing (30 min every 30 min) -Zeigler et al, 2016 52 Standing (variable, 10-30 min about every 60 min) Kerr et al, 2017 43 Light walking (2 min every 60 min) -Bailey et al, 2015 33 Light walking (2 min every 20 min) -Wennberg et al, 2016 48 Light walking (3 min every 30 min) -Freire et al, 2019 42 Light walking (5 min every 20 min) -Zeigler et al, 2016 52 Light walking (variable, 10-30 min about every 60 min) Larsen et al, 2014 46 Light walking (2 min every 20 min) Dempsey et al, 2016 41 Light walking (3 min every 30 min) Yates et al, 2020 51 Light walking (5 min every 30 min) Champion et al, 2018 39 Light walking (20 min every 60 min) Kruse et al, 2018 45 Light intensity desk pedaling (10 min every 60 min) -Zeigler et al, 2016 52 Cycling (variable, 10-30 min about every 60 min) Bhammar et al, 2017 36 Moderate walking (2 min every 20 min) -Larsen et al, 2014 46 Moderate walking (2 min every 20 min) Wheeler et al, 2019b 49 Moderate walking (30 min continuous bout + 3 min every 30 min) Bhammar et al, 2017 36 Vigorous walking (2 min every 60 min) -Kowalsky et al, 2019 44 Resistance exercises (variable, 1.3-2.6 min every 60 min) -Climie et al, 2018 40 Resistance exercises (3 min every 30 min) -Dempsey et al, 2016 41 Resistance exercises (3 min every 30 min) Puig-Ribera et al, 2015 47 Community-based intervention -DBP 42 Light walking (5 min every 20 min) Larsen et al, 2014 46 Light walking (2 min every 20 min) Dempsey et al, 2016 41 Light walking (3 min every 30 min) Kruse e...…”