Effect of brain-derived neurotrophic factor on behavior and key members of the brain serotonin system in genetically predisposed to behavioral disorders mouse strains

Науменко, В. С.; Кондаурова, Е. М.; Базовкина, Д. В.; Цыбко, А. С.; Tikhonova, Maria A.; Куликов, А. В.; Попова, Н. К.

doi:10.1016/j.neuroscience.2012.04.031

Cited by 54 publications

(28 citation statements)

References 60 publications

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“…These results show increased brain 5‐HT system sensitivity to GDNF in mice genetically predisposed to depressive‐like behavior. Taken together with the data on BDNF effects on gene expression and behavior (Naumenko et al, ), these data suggest a principal role of 5‐HT 1A and 5‐HT 2A receptor gene expression in the hippocampus for antidepressant effects of neurotrophic factors.…”

Section: Discussionsupporting

confidence: 71%

“…Recently, we showed a considerable role of the brain 5‐HT system in the antidepressive effect of brain‐derived neurotrophic factor (BDNF) in an animal model of depressive‐like behavior. Concomitantly, a significant genetically defined difference in the response to BDNF was shown in two mouse strains, suggesting a significant role of genotype in the sensitivity to neurotrophic factors (Naumenko et al, ). The aim of the present study was to compare the effect of central acute administration of GDNF on 1) catalepsy, anxiety, and depressive‐like behavior; 2) functional activity of 5‐HT 1A and 5‐HT 2A receptors and the expression of 5‐HT 1A and 5‐HT 2A genes; and 3) expression of the genes encoding 5‐HT transporter and the key enzyme of 5‐HT synthesis in the brain, tryptophan hydroxylase‐2, in mice genetically predisposed to psychopathology (ASC as a model of depressive‐like behavior and cataleptic “nondepressive” mouse strain CBA).…”

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confidence: 99%

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Effect of glial cell line‐derived neurotrophic factor on behavior and key members of the brain serotonin system in mouse strains genetically predisposed to behavioral disorders

Науменко

Базовкина

Семенова

et al. 2013

J of Neuroscience Research

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The effect of glial cell line-derived neurotrophic factor (GDNF) on behavior and on the serotonin (5-HT) system of a mouse strain predisposed to depressive-like behavior, ASC/Icg (Antidepressant Sensitive Cataleptics), in comparison with the parental "nondepressive" CBA/Lac mice was studied. Within 7 days after acute administration, GDNF (800 ng, i.c.v.) decreased cataleptic immobility but increased depressive-like behavioral traits in both investigated mouse strains and produced anxiolytic effects in ASC mice. The expression of the gene encoding the key enzyme for 5-HT biosynthesis in the brain, tryptophan hydroxylase-2 (Tph-2), and 5-HT1A receptor gene in the midbrain as well as 5-HT2A receptor gene in the frontal cortex were increased in GDNF-treated ASC mice. At the same time, GDNF decreased 5-HT1A and 5-HT2A receptor gene expression in the hippocampus of ASC mice. GDNF failed to change Tph2, 5-HT1A , or 5-HT2A receptor mRNA levels in CBA mice as well as 5-HT transporter gene expression and 5-HT1A and 5-HT2A receptor functional activity in both investigated mouse strains. The results show 1) a GDNF-induced increase in the expression of key genes of the brain 5-HT system, Tph2, 5-HT1A , and 5-HT2A receptors, and 2) significant genotype-dependent differences in the 5-HT system response to GDNF treatment. The data suggest that genetically defined cross-talk between neurotrophic factors and the brain 5-HT system underlies the variability in behavioral response to GDNF.

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Section: Discussionsupporting

confidence: 71%

mentioning

confidence: 99%

Effect of glial cell line‐derived neurotrophic factor on behavior and key members of the brain serotonin system in mouse strains genetically predisposed to behavioral disorders

Науменко

Базовкина

Семенова

et al. 2013

J of Neuroscience Research

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“…To our knowledge, the present study is the first to report a CORT‐induced anhedonia in mice. FST and TST are often used to evaluate behavioral despair (David et al, ; Pollak et al, ; Yan et al, ; Naumenko et al, ). The decreases in immobility time following the CORT treatment and the consistent lack of changes across weeks in control mice were in agreement with other studies using a similar CORT treatment regimen (Ago et al, ; Zhao et al, ).…”

Section: Discussionmentioning

confidence: 99%

Subregion‐specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression

Tang

Sun

et al. 2014

Hippocampus

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Stress influences the development of depression, and depression is associated with structural and functional changes in the hippocampus. The current study sought to determine whether chronic corticosteroid (CORT) treatment influences serotonin transporter (5-HTT) protein expression and function in the CA1, CA3, and dentate gyrus (DG) subregions of the hippocampus. Male CD-1 mice were subcutaneously injected with CORT at a dose of 20 mg/kg once daily for 3 weeks. Behavioral state was assessed using sucrose preference, physical state of the coat, forced swimming test, and tail suspension test. We then determine 5-HTT protein expression and synaptosomal 5-HT uptake in the CA1, CA3 and DG subregions. CORT treatment induced anhedonia and behavioral despair, two core endophenotypes of clinical depression; 5-HTT protein expression levels and synaptosomal 5-HT uptake were both decreased in a subregion-specific manner, with the greatest decrease observed in the DG, a moderate decrease in the CA3, and the CA1 showed no apparent change. In addition, a reduction in tissue mass was detected in the DG following the CORT treatment. These data indicate that subregion-specific decreases in hippocampal 5-HTT protein expression and function are associated with endophenotypes of depression.

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“…Briefly, mice received bilateral i.c.v. infusions (4 μL) under isoflurane (4%) anesthesia (Bregma: AP: −0.5 mm, Lat: ±1.6 mm, DV: −2 mm; [26,27]). Following surgery, mice were monitored to ensure weight gain, muscle tone, and proper neurological response and general health [28].…”

Section: Methodsmentioning

confidence: 99%

HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice

Leibrand

Paris

Ghandour

et al. 2017

Neuroscience Letters

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HIV-1 infection results in blood-brain barrier (BBB) disruption, which acts as a rate-limiting step for HIV-1 entry into the CNS and for subsequent neuroinflammatory/neurotoxic actions. One mechanism by which HIV may destabilize the BBB involves actions of the HIV-1 regulatory protein, trans-activator of transcription (Tat). We utilized a conditional, Tat-expressing transgenic murine model to examine the influence of Tat1-86 expression on BBB integrity and to assess the relative numbers of phagocytic perivascular macrophages and microglia within the CNS in vivo. The effects of Tat exposure on sodium-fluorescein (Na-F; 0.376 kDa), horseradish peroxidase (HRP; 44 kDa), and Texas Red-labeled dextran (70 kDa) leakage into the brain were assessed in Tat-exposed (Tat+) and control (Tat−) mice. Exposure to HIV-1 Tat significantly increased both Na-F and HRP, but not the larger sized Texas Red-labeled dextran, confirming BBB breakdown and also suggesting the breach was limited to molecules <70 kDa. Additionally, at 5 d after Tat induction, Alexa Fluor® 488-labeled dextran was bilaterally infused into the lateral ventricles 5 d before the termination of the experiment. Within the caudate/putamen, Tat induction increased the proportion of dextran-labeled Iba-1+ phagocytic perivascular macrophages (~5-fold) and microglia (~3-fold) compared to Tat− mice. These data suggest that HIV-1 Tat exposure is sufficient to destabilize BBB integrity and to increase the presence of activated, phagocytic, perivascular macrophages and microglia in an in vivo model of neuroAIDS.

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Effect of brain-derived neurotrophic factor on behavior and key members of the brain serotonin system in genetically predisposed to behavioral disorders mouse strains

Cited by 54 publications

References 60 publications

Effect of glial cell line‐derived neurotrophic factor on behavior and key members of the brain serotonin system in mouse strains genetically predisposed to behavioral disorders

Effect of glial cell line‐derived neurotrophic factor on behavior and key members of the brain serotonin system in mouse strains genetically predisposed to behavioral disorders

Subregion‐specific decreases in hippocampal serotonin transporter protein expression and function associated with endophenotypes of depression

HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice

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