Effect of BMI on blood value of patients on HCG day with IUI treatment

Abstract

Background This study aims to analyze the effect of the body mass index (BMI) on E2, P and LH values in females who received intrauterine insemination (IUI) treatment on human chorionic gonadotropin (HCG) day. Methods A total of 2319 cycles of IUI-assisted pregnancy treatment were selected in our hospital. Based on the BMI, female infertility patients are divided into three groups: normal weight group, overweight and obese group. Results For patients with natural cycles and ≤ 35 years old, there were 440, 178 and 197 cases in the three groups, respectively. For patients with natural cycles and > 35 years old, there were 90, 83 and 81 cycles in the three groups, respectively. For patients with induced ovulation cycle and ≤ 35 years old, there were 425, 203 and 516 cases in the three groups, respectively. For patients with induced ovulation cycle and > 35 years old, there were 26, 26 and 54 cases in the three groups, respectively. Conclusion When a patient is ≤35 years old, the BMI affects the E2, LH and P values on the day of artificial insemination. However, the BMI is negatively correlated with E2, LH and P in IUI on HCG day. After controlling for age and assisted pregnancy, the correlation analysis revealed that the BMI is negatively correlated with hormone E2 and LH. The higher the BMI was, the lower the levels of hormones E2, LH and P became. However, in the present study, the BMI did not significantly improve the clinical pregnancy rate of patients who received IUI.

Periconceptional biomarkers for maternal obesity: a systematic review

“…Similarly, only one study with a subgroup of women aged < 35 years, reported lower levels of serum LH in obese women compared to women of normal weight, whereas no difference was observed in women aged > 35 years. This was similar to the findings of three other studies [42,43,48,52]. Finally, in one study, BMI correlated negatively with serum LH levels [43].…”

“…This was similar to the findings of three other studies [42,43,48,52]. Finally, in one study, BMI correlated negatively with serum LH levels [43].…”

“…Estrogen Estrogen was analyzed in six different studies of low quality (mean ErasmusAGE score 3.3 out of 10.0). Preconception: No difference was observed in either serum or follicular fluid levels of estradiol between obese women compared to women of normal weight in five studies, with an exception of a subgroup of women aged < 35 years that showed that lower levels were associated with obesity in one study [42,43,46,48,49]. Additionally, one study showed a negative correlation between BMI and serum estradiol levels [43].…”

“…Preconception: In two different studies, obese women undergoing assisted reproductive technology (ART) treatment had lower progesterone levels compared to women of normal weight, whereas in one study, no difference was observed in obese women compared to women of normal weight in natural cycle pregnancies, nor in women aged > 35 years [41,43].…”

Low BMI is associated with poor IUI outcomes: a retrospective study in 13,745 cycles

“…BMI may affect the IUI outcomes in several aspects. While BMI is negatively associated with hormone levels and follicular growth 16 , Souter et al suggested that BMI was positively associated with endometrial thickness, suggesting that higher BMI may be a favorable factor for endometrial receptivity as soon as "the medication and response are adjusted to overcome the weight effect" 14 . Therefore, heterogeneity in medication and the patients' response may contribute to the difference in the effect of BMI shown by previous studies.…”