Effect of Blunt Trauma on the Corneal Endothelium

Effect on corneal endothelial cell count of traumatic microhyphaema and hyphaema

“…This is one of the first prospective studies to look at the detrimental effects of both central and inferior corneal endothelium by traumatic haemorrhage in the anterior chamber. Our study results were largely consistent with those of Slingsby and Forstot (1981).…”

“…1988). Another older study also supported this finding, but it did not show any increased detrimental effect with the severity of the traumatic hyphaema (Slingsby & Forstot 1981).…”

Effect on corneal endothelial cell count of traumatic microhyphaema and hyphaema

“…This is one of the first prospective studies to look at the detrimental effects of both central and inferior corneal endothelium by traumatic haemorrhage in the anterior chamber. Our study results were largely consistent with those of Slingsby and Forstot (1981).…”

“…1988). Another older study also supported this finding, but it did not show any increased detrimental effect with the severity of the traumatic hyphaema (Slingsby & Forstot 1981).…”

Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury

“…Previous studies have shown that ocular trauma can induce corneal endothelial cells (CEnC) swelling and loss 38 , 39 The loss or dysfunction of these cells leads to corneal edema and a decrease in vision 40 . To study the effect of the mechanical injury and CGRP treatment on the CEnC, we collected mouse corneas on day 14 post-injury and stained the corneal endothelium with zonula occludens (ZO-1), a tight junction protein critical for CEnC function and conveniently outlining cell border, and Na + /K + -ATPase (Fig.…”

“…Previous clinical studies have reported such impact of the trauma on the CEnC leading to their swelling and disruption with fibrin and leukocyte accumulation 39 . Moreover, measurable decreases in CEnC density, up to 20%, were noted in patients with a history of blunt ocular trauma 38 , 66 – 68 . Similarly, we observe a significant decrease in endothelial cell density, altered cellular morphology, and reduced expression of pump protein Na + /K + -ATPase after injury, resulting in persistent corneal edema (increased central corneal thickness) in vivo.…”

The effects of blunt trauma and cataract surgery on corneal endothelial cell density

“…found that the traumatic eye had a mean decrease in ECD of 6.4% when compared to that in a normal eye 23. The decrease in ECD was correlated with the degree of trauma 23. Motley et al .…”

Effect on corneal endothelial cell count of traumatic microhyphaema and hyphaema

“…This is one of the first prospective studies to look at the detrimental effects of both central and inferior corneal endothelium by traumatic haemorrhage in the anterior chamber. Our study results were largely consistent with those of Slingsby and Forstot (1981).…”

“…1988). Another older study also supported this finding, but it did not show any increased detrimental effect with the severity of the traumatic hyphaema (Slingsby & Forstot 1981).…”

Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury

“…Previous studies have shown that ocular trauma can induce corneal endothelial cells (CEnC) swelling and loss 38 , 39 The loss or dysfunction of these cells leads to corneal edema and a decrease in vision 40 . To study the effect of the mechanical injury and CGRP treatment on the CEnC, we collected mouse corneas on day 14 post-injury and stained the corneal endothelium with zonula occludens (ZO-1), a tight junction protein critical for CEnC function and conveniently outlining cell border, and Na + /K + -ATPase (Fig.…”

“…Previous clinical studies have reported such impact of the trauma on the CEnC leading to their swelling and disruption with fibrin and leukocyte accumulation 39 . Moreover, measurable decreases in CEnC density, up to 20%, were noted in patients with a history of blunt ocular trauma 38 , 66 – 68 . Similarly, we observe a significant decrease in endothelial cell density, altered cellular morphology, and reduced expression of pump protein Na + /K + -ATPase after injury, resulting in persistent corneal edema (increased central corneal thickness) in vivo.…”

The effects of blunt trauma and cataract surgery on corneal endothelial cell density

“…found that the traumatic eye had a mean decrease in ECD of 6.4% when compared to that in a normal eye 23. The decrease in ECD was correlated with the degree of trauma 23. Motley et al .…”

Effect on corneal endothelial cell count of traumatic microhyphaema and hyphaema

“…This is one of the first prospective studies to look at the detrimental effects of both central and inferior corneal endothelium by traumatic haemorrhage in the anterior chamber. Our study results were largely consistent with those of Slingsby and Forstot (1981).…”

“…1988). Another older study also supported this finding, but it did not show any increased detrimental effect with the severity of the traumatic hyphaema (Slingsby & Forstot 1981).…”

Topical application of calcitonin gene-related peptide as a regenerative, antifibrotic, and immunomodulatory therapy for corneal injury

“…Previous studies have shown that ocular trauma can induce corneal endothelial cells (CEnC) swelling and loss 38 , 39 The loss or dysfunction of these cells leads to corneal edema and a decrease in vision 40 . To study the effect of the mechanical injury and CGRP treatment on the CEnC, we collected mouse corneas on day 14 post-injury and stained the corneal endothelium with zonula occludens (ZO-1), a tight junction protein critical for CEnC function and conveniently outlining cell border, and Na + /K + -ATPase (Fig.…”

“…Previous clinical studies have reported such impact of the trauma on the CEnC leading to their swelling and disruption with fibrin and leukocyte accumulation 39 . Moreover, measurable decreases in CEnC density, up to 20%, were noted in patients with a history of blunt ocular trauma 38 , 66 – 68 . Similarly, we observe a significant decrease in endothelial cell density, altered cellular morphology, and reduced expression of pump protein Na + /K + -ATPase after injury, resulting in persistent corneal edema (increased central corneal thickness) in vivo.…”

The effects of blunt trauma and cataract surgery on corneal endothelial cell density

“…found that the traumatic eye had a mean decrease in ECD of 6.4% when compared to that in a normal eye 23. The decrease in ECD was correlated with the degree of trauma 23. Motley et al .…”