Effect of Black Tea Consumption on Urinary Risk Factors for Kidney Stone Formation

Siener, Roswitha; Hesse, Albrecht

doi:10.3390/nu13124434

Cited by 14 publications

(8 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The expressions of SLC26 family members and their physiologic roles vary considerably between species, suggesting different pathogenic mechanisms of SLC26 mutants between humans and animal models ( SOLEIMANI, 2013 ). Abnormalities of urinary ion concentrations, such as hyperoxaluria, are important pathogenic factors ( SIENER and Hesse, 2021 ). The SLC26 family is centrally involved in oxalate and sulfate ion transport in urolithogenesis, and the STAS structural domain is an important site of action.…”

Section: Discussionmentioning

confidence: 99%

SLC26 family: a new insight for kidney stone disease

Huang

Liu

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

The solute-linked carrier 26 (SLC26) protein family is comprised of multifunctional transporters of substrates that include oxalate, sulphate, and chloride. Disorders of oxalate homeostasis cause hyperoxalemia and hyperoxaluria, leading to urinary calcium oxalate precipitation and urolithogenesis. SLC26 proteins are aberrantly expressed during kidney stone formation, and consequently may present therapeutic targets. SLC26 protein inhibitors are in preclinical development. In this review, we integrate the findings of recent reports with clinical data to highlight the role of SLC26 proteins in oxalate metabolism during urolithogenesis, and discuss limitations of current studies and potential directions for future research.

show abstract

Section: Discussionmentioning

confidence: 99%

SLC26 family: a new insight for kidney stone disease

Huang

Liu

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…However, Shu et al and Wang et al reported that tea consumption was associated with a lower risk of urolithiasis [ 40 , 41 ], especially green tea, which was indicated to have a protective function in kidney stone formation [ 8 ]. While black tea intake did not correlate with a decreased incidence of kidney stones, it did not elevate the risk either [ 42 ]. Our study lends further support to these findings by identifying tea consumption as a causal factor associated with a lower risk of kidney stone formation.…”

Section: Discussionmentioning

confidence: 99%

Univariable and multivariable mendelian randomization study revealed the modifiable risk factors of urolithiasis

Fang,

Deng,

Chen

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Background Urolithiasis is a common urological disease with increasing incidence worldwide, and preventing its risk poses significant challenges. Here, we used Mendelian randomization (MR) framework to genetically assess the causal nature of multifaceted risk factors on urolithiasis. Methods 17 potential risk factors associated with urolithiasis were collected from recently published observational studies, which can be categorized basically into lifestyle factors and circulating biomarkers. The instrumental variables of risk factors were selected from large-scale genome-wide association studies (N ≤ 607,291). Summary-level data on urolithiasis were obtained from UK Biobank (UKB) (3,625 cases and 459,308 noncases) and the FinnGen consortium (5,347 cases and 213,445 noncases). The univariable and multivariable MR analyses were applied to evaluate the causal, independent effect of these potential risk factors upon urolithiasis. Effects from the two consortia were combined by the meta-analysis methods. Results Higher genetically predicted sex hormone-binding globulin (SHBG, OR, 0.708; 95% CI, 0.555 to 0.903), estradiol (OR, 0.179; 95% CI, 0.042 to 0.751), tea intake (OR, 0.550; 95% CI, 0.345 to 0.878), alcoholic drinks per week (OR, 0.992; 95% CI, 0.987 to 0.997), and some physical activity (e.g., swimming, cycling, keeping fit, and bowling, OR, 0.054; 95% CI, 0.008 to 0.363) were significantly associated with a lower risk of urolithiasis. In the Multivariate Mendelian Randomization (MVMR) analyses, the significant causal associations between estradiol, SHBG, tea intake, and alcoholic drinks per week with urolithiasis were robust even after adjusting for potential confounding variables. However, the previously observed causal association between other exercises and urolithiasis was no longer significant after adjusting for these factors. Conclusions The univariable and multivariable MR findings highlight the independent and significant roles of estradiol, SHBG, tea intake, and alcoholic drinks per week in the development of urolithiasis, which might provide a deeper insight into urolithiasis risk factors and supply potential preventative strategies.

show abstract

“…However, data from a cohort study suggested only a modest positive association between dietary oxalate intake and the risk of kidney stone formation ( 37 ). Besides, the consumption of the oxalate-rich black tea did not significantly alter 24-h urinary oxalate excretion ( 38 ). The modest effects of urinary oxalate might have been offset by a large increase in fluid intake while drinking tea.…”

Section: Discussionmentioning

confidence: 99%

Association between tea intake and hospitalized nephrolithiasis in Chinese adults: A case–control study

Liu

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

Introduction and aimNephrolithiasis is one of the most common urological disorders worldwide. Tea is one of the most popular drinks worldwide. This study aimed to explore the association between tea intake and hospitalized nephrolithiasis in Chinese adults.MethodsThe patients and healthy participants were from the Shenyang sub-cohort of Tianjin Chronic Low-Grade Systemic Inflammation and Health Cohort Study. After selecting and matching by age (±1 year) and sex using the 1:2 ratio, 834 participants were included in this study. Of these, 278 patients had hospitalized nephrolithiasis and 556 were healthy controls. The tea intake was assessed using a validated self-administered food frequency questionnaire. Multivariate conditional logistic regression analysis was used to evaluate the association between tea intake and hospitalized nephrolithiasis.ResultsAfter adjustment, a higher frequency of tea intake was found to be negatively associated with the risk of hospitalized nephrolithiasis. Compared with participants who never drank tea, the odds ratio (95% confidence interval) [OR (95% CI)] for participants who drank ≥1 cup (180 mL) of tea per day was 0.418 (0.192–0.911) (P for trend = 0.013). Moreover, the adjusted OR (95% CI) for participants who drank ≥1 cup of green tea and black tea per day was 0.189 (0.069–0.520) (P for trend <0.001) and 1.248 (0.437–3.559) (P for trend = 0.654), respectively.ConclusionsIncreased tea intake was found to be associated with a lower risk of hospitalized nephrolithiasis among Chinese adults. This finding may assist in the prevention of hospitalized nephrolithiasis.

show abstract

Effect of Black Tea Consumption on Urinary Risk Factors for Kidney Stone Formation

Cited by 14 publications

References 45 publications

SLC26 family: a new insight for kidney stone disease

SLC26 family: a new insight for kidney stone disease

Univariable and multivariable mendelian randomization study revealed the modifiable risk factors of urolithiasis

Association between tea intake and hospitalized nephrolithiasis in Chinese adults: A case–control study

Contact Info

Product

Resources

About