Effect of bivalirudin on neointimal hyperplasia and endothelial proliferation in rabbit

Gencpinar, Tugra; Bayrak, Serdar; Bilen, Çağatay; Kemahli, Mustafa Baris; Akokay, Pınar; Barış, Mustafa; Erdal, Cenk

doi:10.1007/s11748-020-01454-8

Cited by 1 publication

(2 citation statements)

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“…In addition, rivaroxaban's inhibitory effects on angiogenesis were also observed, as well as neovascularization inducing effects [27][28]. On the other hand, Bivalirudin, another direct thrombin inhibitor used intravenously, has a protective effect against intimal hyperplasia in rabbit carotid artery [29]. When evaluated together with our study, the preventive effect of intimal hyperplasia observed in Rivaroxaban and Apixaban may be related to the factor Xa inhibitor drug group rather than the Direct Oral Anticoagulant Group.…”

Section: Discussionsupporting

confidence: 58%

“…The surgeries were performed by the investigators at the institution in accordance with the "Principles of Laboratory Animal Care". The rabbit carotid artery model was chosen due to being an easily applicable and reproductive anastomosis model when compared to the rat model (3 R Principle) [2,26,29]. The rabbits that served as the control group, these animals underwent sham surgery to replicate the same handling and treatment protocols used for the rabbits that received carotid artery transection and re-anastomosis.…”

Section: Methodsmentioning

confidence: 99%

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Effects Of Rivaroxaban And Apixaban On Intimal Hyperplasia In Rabbits

Kemahli¹,

Gencpinar²,

DURSUN>³

et al. 2022

Turk J Vasc Surg

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Aim: Intimal hyperplasia causes vascular occlusion and its optimal treatment is unknown. In this study, we evaluated the effectiveness of Apixaban and Rivaroxaban treatment for preventing intimal hyperplasia in rabbits. Material and Methods: The rabbits (n = 15) were randomly divided into three groups. Reanastomoses are applied to the carotid artery. All groups received 100 U/kg heparin sodium during the operation period. Group A (n = 5) as a control group had no medication. Group B (n = 5) was given Rivaroxaban 3 mg/kg/day. In-group C (n = 5) Apixaban was administered per orally 10 mg/kg. At the end of the treatment on the 28th day, carotid artery specimens were excised and evaluated histologically. Results: Increased intima thickness was observed in the control group than the drug groups (P=0.019, P=0.007). It was found that there was no difference between groups in terms of lumen diameter, lumen area, tunica media area and tunica media thickness. There was difference between groups in terms of caspase 3 or TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) staining (p<0.05). Conclusion: Apixaban and Rivaroxaban may have protective efficacy against intimal hyperplasia after vascular surgical intervention.

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Section: Discussionsupporting

confidence: 58%

Section: Methodsmentioning

confidence: 99%